Archives of Osteoporosis, Journal Year: 2024, Volume and Issue: 19(1)
Published: Oct. 4, 2024
Language: Английский
Obesity Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Summary The rapid and widespread clinical adoption of highly effective incretin‐mimetic drugs (IMDs), particularly semaglutide tirzepatide, for the treatment obesity has outpaced updating practice guidelines. Consequently, many patients may be at risk adverse effects uncertain long‐term outcomes related to use these drugs. Of emerging concern is loss skeletal muscle mass function that can accompany substantial weight reduction; such losses lead reduced functional metabolic health, cycling, compromised quality life, other outcomes. Available evidence suggests trial participants receiving IMDs lost 10% or more their during 68‐ 72‐week interventions, approximately equivalent 20 years age‐related loss. ability maintain caloric restriction‐induced reduction influenced by two key factors: nutrition physical exercise. Nutrition therapy should ensure adequate intake absorption high‐quality protein micronutrients, which require oral nutritional supplements. Additionally, concurrent activity, especially resistance training, been shown effectively minimize therapy. All participate in comprehensive programs emphasizing micronutrient intakes, as well preserve function, maximize benefit IMD therapy, potential risks.
Language: Английский
Citations
21
Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 172 - 172
Published: Jan. 4, 2024
Today, type 2 diabetes mellitus (T2DM) and skeletal muscle atrophy (SMA) have become increasingly common occurrences. Whether the onset of T2DM increases risk SMA or vice versa has long been under investigation. Both conditions are associated with negative changes in health, which can, turn, lead to impaired physical function, a lowered quality life, an increased mortality. Poor nutrition can exacerbate both SMA. linked by vicious cycle events that reinforce worsen each other. Muscle insulin resistance appears be pathophysiological link between To explore this association, our review (i) compiles evidence on clinical association SMA, (ii) reviews mechanisms underlying biochemical muscles people at (iii) examines how nutritional therapy activity as muscle-targeted treatments benefit population. Based evidence, we conclude effective treatment patients T2DM-SMA depends restoration maintenance mass. We thus propose regular intake key functional nutrients, along guidance for activity, help maintain euglycemia improve status all
Language: Английский
Citations
20
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 13, 2023
Oral semaglutide is the first glucagon-like peptide-1 receptor agonist (GLP-1RA) designed for oral administration; it offers a promising opportunity to facilitate an early approach Type 2 Diabetes (T2D). The study aimed evaluate, in real-life setting, effects of on body composition patients with T2D after 26 weeks therapy.Thirty-two were evaluated at baseline (T0) and three (T3) six (T6) months therapy semaglutide. At each time point, was assessed using phase sensitive bioimpedance analyzer. Clinical, anthropometric laboratory parameters, main biometric surrogates liver steatosis fibrosis, also analyzed compared.A significant reduction glucometabolic alanine aminotransferase, Fatty Liver Index, Fat Mass observed. Visceral Adipose Tissue (VAT) decreased, while Free Skeletal Muscle (SMM) preserved during therapy, resulting beneficial increase SMM/VAT ratio. Finally, overall improvement fluid distribution observed.Our real-world data confirm clinical efficacy highlight its ability improve nutritional status T2D.
Language: Английский
Citations
32
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 24, 2024
Sarcopenia, a condition characterized by diminished skeletal muscle mass, strength, and function, accompanied inflammation oxidative stress, remains an area of limited exploration concerning its correlation with the Oxidative Balance Score (OBS).
Language: Английский
Citations
15
Current Obesity Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 532 - 544
Published: May 16, 2024
Sarcopenic obesity (SO), defined as the coexistence of excess fat mass and reduced skeletal muscle strength, has emerged an important cardiovascular risk factor, particularly in older adults. This review summarizes recent findings on diagnosis, prevalence, health impacts, treatment SO.
Language: Английский
Citations
13
Archives of Public Health, Journal Year: 2025, Volume and Issue: 83(1)
Published: Jan. 10, 2025
Sarcopenia is an age-related syndrome marked by a gradual decline in skeletal muscle mass and function. While various factors influencing sarcopenia have been studied, the link between daily sedentary time remains underexplored. This study analyzed association sitting using data from National Health Nutrition Examination Survey (NHANES 2011–2018). Daily was assessed through questionnaires, while measured body index (BMI) adjusted appendicular (ASM). The relationship weighted logistic regression models smoothing curves. Stratified analyses interaction testing were employed to investigate population-specific characteristics of this association. Furthermore, chi-square test grouped used further analyze impact vigorous activity on two variables. included 9998 participants with complete information. fully model showed significant positive correlation prevalence (OR = 1.07, 95% CI: 1.03–1.10, P 0.0026). group ≥ 9 h had 90% higher risk compared < 4 1.90, 1.22–2.84, 0.0040). Smooth curve fitting analysis linear relationship. shows that non-Hispanic white men lower BMI (BMI 25) sarcopenia. Compared those who actively participate activities, individuals lack recreational activities Our research has found increased significantly increases sarcopenia, especially among BMI. Additionally, physical also Therefore, reducing behavior increasing moderate exercise may be effective prevention strategies.
Language: Английский
Citations
1
Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 2991 - 2991
Published: June 30, 2023
Many countries are facing the advent of super-aging societies, where sarcopenia and frailty will become pertinent problems. The prevalence comorbidities is a major problem in with aged populations as elderly people suffer from various diseases, such diabetes, heart failure, chronic kidney disease dementia. All these diseases associated frailty, they frequently cause falls, fractures, decline activities daily living. Fractures bone fragility, which influenced by diabetes disease. Nutritional support for patients sarcopenic individuals adequate energy protein intake, vitamin D supplementation, blood glucose level management obesity prevention, nutritional education healthy individuals, enlightenment society could be crucial to solve health-related problems societies.
Language: Английский
Citations
21
Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Abstract Excess adiposity is at the root of type 2 diabetes (T2D). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as first‐line treatments for T2D based on significant weight loss results. The composition using most diets consists <25% fat‐free mass (FFM) loss, with remainder from fat stores. Higher amounts (achieved metabolic bariatric surgery) result in greater reductions FFM. Our aim was to assess impact that GLP‐1RA‐based We analysed studies reported changes FFM following agents: exenatide, liraglutide, semaglutide, and dual incretin agonist tirzepatide. performed an analysis various interventions provide a reference expected evaluated dual‐energy X‐ray absorptiometry (DXA) measuring (a crude surrogate skeletal muscle). In evaluating percentage lost (%FFML) equal ΔFFM/total change. %FFML agents between 20% 40%. 28 clinical trials evaluated, proportion highly variable, but majority exceeding 25%. review limited small substudies use DXA, which does not measure muscle directly. Since contains variable amount (approximately 55%), this indirect may explain heterogeneity data. Assessing quantity quality advanced imaging (magnetic resonance imaging) functional testing will help fill gaps our current understanding.
Language: Английский
Citations
7
Diabetes & Metabolism Journal, Journal Year: 2023, Volume and Issue: 47(6), P. 719 - 742
Published: Sept. 14, 2023
Type 2 diabetes mellitus (T2DM) and sarcopenia (low skeletal muscle mass function) share a bidirectional relationship. The prevalence of these diseases increases with age they common risk factors. Skeletal fat infiltration, commonly referred to as myosteatosis, may be major contributor both T2DM in older adults via independent effects on insulin resistance health. Many strategies manage result energy restriction subsequent weight loss, this can lead significant declines the absence exercise, which is also first-line treatment for sarcopenia. In review, we highlight recent evidence established treatments emerging therapies targeting loss function improvements with, or at of, and/or This includes dietary, physical activity exercise interventions, new generation incretin-based agonists myostatin-based antagonists, endoscopic bariatric therapies. We how digital health technologies literacy interventions increase uptake adherence to,
Language: Английский
Citations
16
Life Sciences, Journal Year: 2023, Volume and Issue: 329, P. 121975 - 121975
Published: July 24, 2023
Language: Английский
Citations
12