Endocrine, Journal Year: 2024, Volume and Issue: 85(1), P. 222 - 232
Published: Feb. 20, 2024
Language: Английский
Endocrine Reviews, Journal Year: 2022, Volume and Issue: 44(2), P. 143 - 192
Published: May 29, 2022
Abstract Brown adipose tissue (BAT) displays the unique capacity to generate heat through uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for cardiometabolic diseases. Here, we review BAT cellular metabolism, its regulation by central nervous and endocrine systems circulating metabolites, plausible roles of this in human thermoregulation, energy balance, disorders, current knowledge on pharmacological stimulation humans. The definition measurement studies relies almost exclusively glucose uptake from positron emission tomography with 18F-fluorodeoxiglucose, which can be dissociated thermogenic activity, as example insulin-resistant states. most important substrate thermogenesis is intracellular fatty acid content mobilized sympathetic triglyceride lipolysis. This lipolytic response intertwined white (WAT) other metabolic tissues, cannot independently stimulated drugs tested thus far. an interesting biologically has yet fully selectively activated increase body’s shift balance. field research need methods able directly, specifically, reliably measure while also tracking related responses WAT tissues. Until achieved, uncertainty will remain about role played fascinating
Language: Английский
Citations
102
Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(6), P. 775 - 790
Published: June 27, 2022
Language: Английский
Citations
73
Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(4), P. 270 - 289
Published: Dec. 12, 2023
Language: Английский
Citations
60
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 11, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies found that activating brown tissue browning white can protect against obesity-related metabolic disease. has gradually appealing therapeutic target for prevention re-versal obesity. some important issues remain unresolved. It not certain whether increasing activity cause or effect weight loss what risks might be sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize and/or such as cold exposure, exercise, small-molecule treatment. We highlight functional mechanisms treatment transplantation using batokine, system gut microbiome. Finally, discuss causality between induced by bariatric surgery, activity.
Language: Английский
Citations
58
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 9, 2025
N6-methyladenosine (m6A) is among the most abundant mRNA modifications, yet its cell-type-specific regulatory roles remain unclear. Here we show that m6A methyltransferase-like 14 (METTL14) differentially regulates transcriptome in brown versus white adipose tissue (BAT and WAT), leading to divergent metabolic outcomes. In humans mice with insulin resistance, METTL14 expression differs significantly from BAT WAT context of correlation sensitivity. Mettl14-knockout promotes prostaglandin secretion, improving systemic Conversely, triggers adipocyte apoptosis resistance. m6A-seq RNA-seq integration revealed upregulated biosynthesis pathways apoptotic Mettl14 deficiency. Stable METTL14-knockout hBAs/hWAs METTL14-mediated decay PTGES2 CBR1 hBAs TRAIL TNFR1 hWAs. These data shed light on ability impact metabolism a manner implications for influencing pathophysiology diseases. N6 - methyladenosine (m6 A) prevalent modification, cell-type specific remains Here, authors m6 A modification transcriptomes tissue, resulting distinct impacts metabolism.
Language: Английский
Citations
2
Nutrients, Journal Year: 2022, Volume and Issue: 14(8), P. 1597 - 1597
Published: April 12, 2022
The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with a dramatic decline in physical activity are the alleged main causes for this pandemic. While they undoubtedly represent contributors to problem, not able fully explain all cases current trends. In context, body knowledge related exposure as yet underappreciated obesogenic factors, which can be referred "exposome", merits detailed analysis. Contrarily genome, "exposome" is subject great dynamism variability, unfolds throughout individual's lifetime. development precise ways capturing full spectrum person extraordinarily demanding. Data derived from epidemiological studies linking excess weight elevated ambient temperatures, utero, intergenerational effects well epigenetics, microorganisms, microbiota, sleep curtailment, endocrine disruptors, among others, suggests possibility that may work alone or synergistically several alternative putative global epidemic. This narrative review reports available evidence on drivers Broadly based interventions needed better identify these at same time stimulating reflection potential relevance perpetuation
Language: Английский
Citations
69
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(2), P. 468 - 491
Published: Nov. 10, 2023
G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and Takeda receptor 5 (TGR5) is member this family. As receptor, TGR5 widely distributed in different parts the human body plays vital role regulating metabolism, including processes energy consumption, weight loss blood glucose homeostasis. Recent studies have shown that an important lipid metabolism disorders such as fatty liver, obesity diabetes. With global situation becoming more serious, comprehensive explanation mechanism filling gaps knowledge concerning clinical ligand drugs urgently needed. In review, we mainly explain anti-obesity to promote further study target, show electron microscope structure review recent on ligands illustrate specific binding between sites ligands, which can effectively provide new ideas for research drug research.
Language: Английский
Citations
32
Life Metabolism, Journal Year: 2024, Volume and Issue: 3(2)
Published: Jan. 20, 2024
In addition to their pivotal roles in energy storage and expenditure, adipose tissues play a crucial part the secretion of bioactive molecules, including peptides, lipids, metabolites, extracellular vesicles, response physiological stimulation metabolic stress. These secretory factors, through autocrine paracrine mechanisms, regulate various processes within tissues. include adipogenesis, glucose lipid metabolism, inflammation, adaptive thermogenesis, all which are essential for maintenance balance functionality tissue micro-environment. A subset these adipose-derived factors can enter circulation target distant appetite, cognitive function, insulin sensitivity, gluconeogenesis, cardiovascular remodeling, exercise capacity. this review, we highlight role signaling pathways modulating homeostasis. Furthermore, delve into alterations both content under pathological conditions, shedding light on potential pharmacological treatment strategies related diseases.
Language: Английский
Citations
11
Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 1, 2025
Brown adipose tissue (BAT) and thermogenic beige fat within white (WAT), collectively known as adaptive fat, dissipate energy heat, offering promising therapeutic potential to combat obesity metabolic disorders. The specific biological functions of these depots are determined by their unique interaction with the microenvironments, composed immune cells, endothelial pericytes, nerve fibers. Immune cells residing in play a key role regulating expenditure systemic homeostasis. dynamic microenvironment is essential for maintaining health function. infiltrate both BAT WAT, contributing homeostasis activation through intricate cellular communications. Emerging evidence underscores importance various cell populations tissue, though many remain undercharacterized. This review provides comprehensive overview that regulate thermogenesis complex interactions niche, highlighting influence contribute interventions syndrome.
Language: Английский
Citations
1
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: Sept. 16, 2022
Abstract The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has reached pandemic levels worldwide increased gradually. Most them are listed on the table high-risk factors for malignancy, metabolic disorders systematically or locally contribute to cancer progression poor prognosis patients. Importantly, adipose tissue is fundamental occurrence development these disorders. White stores excessive energy, while thermogenic fat including brown beige dissipates energy generate heat. In addition thermogenesis, adipocytes also function as dynamic secretory cells a sink nutrients, glucose, fatty acids, amino acids. Accordingly, strategies that activate expand offer therapeutic promise combat overweight, diabetes, other through increasing expenditure enhancing glucose tolerance. With better understanding its origins biological functions advances in imaging techniques detecting roles tumors have been revealed On one hand, enhanced browning subcutaneous results weight loss cancer-associated cachexia. activated tumor microenvironment accelerate by offering fuel sources likely develop resistance chemotherapy. Here, we enumerate current knowledge about significant made origin physiological fat. addition, discuss multiple different tumors. Ultimately, summarize technologies identifying pharmacologic agents via modulating thermogenesis preclinical experiments clinical trials.
Language: Английский
Citations
35