Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of gut microbiome as a tractable therapeutic target for gastrointestinal, mental brain health. Current research is still marked by many open questions that undermine widespread application humans. For example, lack mechanistic understanding probiotic effects means it remains unclear why even apparently closely related strains exhibit different in vivo. live microbial psychobiotics, consensus on their adjunct treatments conventional neuromodulators, use unmedicated populations or at‐risk cohorts with sub‐clinical symptomatology warranted. This missing information both sides equation when treating central nervous system (CNS) conditions makes psychobiotic challenging, especially compared other pharmaceutical functional food approaches. Expediting transition from positive preclinical data proven benefits humans includes interpreting promises pitfalls animal behavioural assays, well navigating mechanism‐informed decision making select right microbe(s) job. In this review, we consider how these decisions can be supported light accrued range clinical studies across healthy, pathological study populations, where specific have been evaluated context gastrointestinal physiology, function behaviour. Examples successful, partial unsuccessful translation bench bedside are considered. We also discuss developments silico analyses enhanced our moved towards pinpointing host–microbe interactions most important optimal gut–brain function. Combining assays vitro ex vivo domains incorporating model organisms prime discovery pipelines promising rationally selected candidates.

Language: Английский

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Gut–brain axis and neuropsychiatric health: recent advances

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 27, 2025

The gut–brain axis, a bidirectional communication pathway, permits the central nervous system (CNS) to exert influence over gastrointestinal function in response stress, while gut microbiota regulates CNS via immune, neuroendocrine, and vagal pathways. Current research highlights importance of stress-related disorders need for further into mechanisms communication, with potential therapeutic implications wide range health conditions. This is challenge taken on this Scientific Reports Collection Gut-Brain Axis. axis has significant neurodegenerative, psychiatric, metabolic disorders. Recent studies have underscored role microbiome conditions such as Parkinson's disease (PD), evidence indicating that dysfunction pathological features can precede motor symptoms by decades. use vivo animal models demonstrated preformed α-synuclein fibrils (PFFs) travel from brain dosage-dependent manner, thereby supporting "gut-first" theory context PD, explored using vitro approaches. There also plays obesity machine learning algorithms may assist differentiating between obese overweight individuals based their data. growing interest at interface post-traumatic stress disorder (PTSD), sleep disturbances, irritable bowel syndrome (IBS). described support expand observations previous preclinical clinical investigations, providing essential novel insights drive discovery previously unexplored avenues brain-gut-microbiome interactions disease.

Language: Английский

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Hydrogen Sulfide (H2S) Generated in the Colon Induces Neuropathic Pain by Activating Spinal NMDA Receptors in a Rodent Model of Chronic Constriction Injury

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Jan. 30, 2025

Language: Английский

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The Inflammatory Mechanism of Parkinson’s Disease: Gut Microbiota Metabolites Affect the Development of the Disease Through the Gut–Brain Axis

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 159 - 159

Published: Feb. 6, 2025

Parkinson's disease is recognized as the second most prevalent neurodegenerative disorder globally, with its incidence rate projected to increase alongside ongoing population growth. However, precise etiology of remains elusive. This article explores inflammatory mechanisms linking gut microbiota disease, emphasizing alterations in and their metabolites that influence disease's progression through bidirectional transmission signals along gut-brain axis. Building on this mechanistic framework, further discusses research methodologies treatment strategies focused metabolites, including metabolomics detection techniques, animal model investigations, therapeutic approaches such dietary interventions, probiotic treatments, fecal transplantation. Ultimately, aims elucidate relationship between underlying thereby paving way for novel avenues condition.

Language: Английский

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Multi-omics analysis explore the mechanism of deoxynivalenol inhibiting rabbit appetite through microbial-gut-brain axis

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117849 - 117849

Published: Feb. 1, 2025

Deoxynivalenol (DON) is one of the most prevalent mycotoxins and can induce weight loss vomiting in animals. This study aimed to elucidate molecular mechanisms underlying DON-induced anorexia rabbits through microbial-gut-brain axis. A total forty were randomly divided into a DON group control group, receiving 1.5 mg/kg.BW an equivalent volume saline daily via intragastric administration, respectively. The pre-treatment period lasted for 7 days, followed by formal experimental 24 days. findings revealed that exposure significantly reduced food intake gain, leading intestinal apoptosis barrier injuries. 16S rRNA sequencing data indicated decreased diversity richness cecal microflora, suppressed probiotic populations, disrupted host lipid metabolism. RNA-Seq iTRAQ used cross-analyze shared differentially expressed genes (DEGs) proteins (DEPs) hypothalamus jejunum, along with their enrichment pathways, indicating TNF-α, NF-κB, NPY may play pivotal roles anorexia. qRT-PCR Western blotting results confirmed significant increases mRNA protein expression levels NF-κB 5-HT2A both jejunum. In conclusion, ingestion disrupt barrier, up-regulate IFN-γ, intestine, trigger immuno-inflammatory response axis, ultimately resulting appetite suppression loss.

Language: Английский

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The gut microbiota-immune-brain axis: Therapeutic implications

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101982 - 101982

Published: March 1, 2025

Language: Английский

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Polysaccharide extracted from Sarcandra glabra residue attenuate cognitive impairment by regulating gut microbiota in diabetic mice

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132121 - 132121

Published: May 6, 2024

Language: Английский

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Zebrafish: A trending model for gut-brain axis investigation

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 270, P. 106902 - 106902

Published: March 17, 2024

Language: Английский

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Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(8), P. 475 - 494

Published: July 4, 2024

Language: Английский

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Lingguizhugan decoction ameliorates cognitive impairment in AD-like mice by influencing the microbiome–gut–brain axis mediated by SCFAs

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155942 - 155942

Published: Aug. 10, 2024

Language: Английский

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