The spatial organization of transcriptional control DOI
Antonina Hafner, Alistair N. Boettiger

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 24(1), P. 53 - 68

Published: Sept. 14, 2022

Language: Английский

Determinants of enhancer and promoter activities of regulatory elements DOI
Robin Andersson, Albin Sandelin

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 21(2), P. 71 - 87

Published: Oct. 11, 2019

Language: Английский

Citations

598
Recent advancements in molecular marker-assisted selection and applications in plant breeding programmes DOI Creative Commons
Nazarul Hasan,

Sana Choudhary,

Neha Naaz

et al.

Journal of Genetic Engineering and Biotechnology, Journal Year: 2021, Volume and Issue: 19(1), P. 128 - 128

Published: Aug. 27, 2021

DNA markers improved the productivity and accuracy of classical plant breeding by means marker-assisted selection (MAS). The enormous number quantitative trait loci (QTLs) mapping read for different species have given a plenitude molecular marker-gene associations. In this review, we discussed positive aspects its precise applications in programmes. Molecular has considerably shortened time new crop varieties to be brought market. To explore information about markers, many reviews been published last few decades; all these were intended breeders obtain on genetics. synopsis recent developments their application programmes devoted early with little or no knowledge markers. progress made breeding, genetics, genomics selection, editing genome contributed comprehensive understanding provides several proofs genetic diversity available plants greatly complemented devices. MAS revolutionized process acceleration accuracy, which is continuously empowering around world.

Language: Английский

Citations

327
Enhancer RNAs are an important regulatory layer of the epigenome DOI
Vittorio Sartorelli, Shannon Lauberth

Nature Structural & Molecular Biology, Journal Year: 2020, Volume and Issue: 27(6), P. 521 - 528

Published: June 1, 2020

Language: Английский

Citations

280
Mechanisms of enhancer action: the known and the unknown DOI Creative Commons

Anil K. Panigrahi,

Bert W. O’Malley

Genome biology, Journal Year: 2021, Volume and Issue: 22(1)

Published: April 15, 2021

Abstract Differential gene expression mechanisms ensure cellular differentiation and plasticity to shape ontogenetic phylogenetic diversity of cell types. A key regulator differential programs are the enhancers, gene-distal cis -regulatory sequences that govern spatiotemporal quantitative dynamics target genes. Enhancers widely believed physically contact promoters effect transcriptional activation. However, our understanding full complement regulatory proteins definitive mechanics enhancer action is incomplete. Here, we review recent findings present some emerging concepts on also outline a set outstanding questions.

Language: Английский

Citations

263
Advances in targeting ‘undruggable’ transcription factors with small molecules DOI
Matthew J. Henley, Angela N. Koehler

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(9), P. 669 - 688

Published: May 18, 2021

Language: Английский

Citations

260
Roles of transposable elements in the regulation of mammalian transcription DOI
Raquel Fueyo, Julius Judd, Cédric Feschotte

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(7), P. 481 - 497

Published: Feb. 28, 2022

Language: Английский

Citations

259
The relationship between genome structure and function DOI
A. Marieke Oudelaar, Douglas R. Higgs

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 22(3), P. 154 - 168

Published: Nov. 24, 2020

Language: Английский

Citations

249
The epigenetic basis of cellular heterogeneity DOI
Benjamin C. Carter, Keji Zhao

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 22(4), P. 235 - 250

Published: Nov. 26, 2020

Language: Английский

Citations

238
DNA G-quadruplex structures: more than simple roadblocks to transcription? DOI Creative Commons
Jenna Robinson, Federica Raguseo, Sabrina Pia Nuccio

et al.

Nucleic Acids Research, Journal Year: 2021, Volume and Issue: 49(15), P. 8419 - 8431

Published: July 5, 2021

It has been >20 years since the formation of G-quadruplex (G4) secondary structures in gene promoters was first linked to regulation expression. Since then, development small molecules selectively target G4s and their cellular application have contributed an improved understanding how regulate transcription. One model that arose from this work placed these non-canonical DNA as repressors transcription by preventing polymerase processivity. Although a considerable number studies recently provided sufficient evidence reconsider simplistic model, there is still misrepresentation transcriptional roadblocks. In review, we will challenge depicting simple 'off switches' for expression articulating potential alter at many different levels, acting key regulatory element perturbing nature epigenetic marks chromatin architecture.

Language: Английский

Citations

220
Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner DOI Creative Commons
Stefan Golfier, Thomas Quail, Hiroshi Kimurâ

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: May 12, 2020

Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for organization these cell cycle phases are different, it is unknown whether loop dynamics that extrude DNA also differ. Here, we used Xenopus egg extracts reconstitute image single molecules during cycle. We show loops form both metaphase interphase, but with distinct dynamic properties. Condensin extrudes non-symmetrically metaphase, whereas cohesin symmetrically interphase. Our data general underlying organization, properties biochemically regulated

Language: Английский

Citations

215