Food Frontiers,
Journal Year:
2023,
Volume and Issue:
4(1), P. 47 - 59
Published: Jan. 5, 2023
Abstract
Biological
rhythm
is
a
natural
physiological
phenomenon
of
the
human
body,
which
regulated
by
biological
system,
including
sleep
cycle,
body
temperature
fluctuation,
endocrine
level,
metabolism,
and
so
on.
Sleep
disturbance
one
main
manifestations
circadian
disorder,
has
serious
impact
on
people's
work
quality
life.
Studies
have
shown
that
gut
microbiota
rhythms
can
interact
through
brain–gut
pathway.
Tea
polyphenols
effectively
modulate
composition
intestinal
microbiota.
The
interaction
between
suggests
intervention
with
tea
possible
way
for
improving
sleep.
Therefore,
investigating
regulation
mechanism
mediated
microbiota,
we
shed
new
light
relationship
metabolic
disturbances,
as
well
beneficial
effect
improving.
Communications Biology,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: Jan. 24, 2025
Recent
genome-wide
association
studies
(GWASs)
of
several
individual
sleep
traits
have
identified
hundreds
genetic
loci,
suggesting
diverse
mechanisms.
Moreover,
are
moderately
correlated,
so
together
may
provide
a
more
complete
picture
health,
while
illuminating
distinct
domains.
Here
we
construct
novel
health
scores
(SHSs)
incorporating
five
core
self-report
measures:
duration,
insomnia
symptoms,
chronotype,
snoring,
and
daytime
sleepiness,
using
additive
(SHS-ADD)
principal
components-based
(SHS-PCs)
approaches.
GWASs
these
six
SHSs
identify
28
significant
loci
adjusting
for
multiple
testing
on
(p
<
8.3e-9),
along
with
341
previously
reported
5e-08).
The
heritability
the
first
three
SHS-PCs
equals
or
exceeds
that
SHS-ADD
(SNP-h2
=
0.094),
revealing
sleep-domain-specific
discoveries.
Significant
enrich
in
brain
tissues
metabolic
neuronal
pathways.
Post-GWAS
analyses
uncover
mechanisms
underlying
reveal
connections
(including
potential
causal
links)
to
behavioral,
psychological,
cardiometabolic
traits.
Data-driven
composite
scores,
combining
self-reported
insomnia,
heritable,
interpretable
phenotypes
GWAS
discoveries
elucidating
regulatory
Proceedings of the Royal Society B Biological Sciences,
Journal Year:
2025,
Volume and Issue:
292(2041)
Published: Feb. 1, 2025
The
Centers
for
Disease
Control
and
Prevention
declared
sleep-related
problems
to
be
a
public
health
epidemic.
With
the
advent
of
biometric
sleep
tracking
technology
taking
lab
into
field,
study
human
is
now
global,
these
new
datasets
show
contrasting
findings.
Previous
reports
suggest
in
small-scale,
non-industrial
societies
short
fragmented
yet
characterized
by
greater
circadian
rhythmicity.
However,
role
rhythm
indicators
understanding
global
variations
patterns
remains
unclear.
We
examine
population-level
studies
(
n
=
54)
using
polysomnography
actigraphy
test
restriction
epidemic
hypothesis,
which
posits
that
labour
demands
technological
disruption
large-scale,
industrial
have
reduced
duration.
used
an
actigraphy-generated
function
index
from
both
866)
mismatch
suggests
poor
chronohygiene
regulated
environments
misaligns
rhythms
societies.
In
rejection
our
results
experience
longest,
most
efficient
sleep,
whereas
support
sleepers
are
greatest
function.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
2(1)
Published: May 10, 2025
Abstract
The
circadian
clock
orchestrates
vital
physiological
functions,
with
its
dysregulation
implicated
in
various
pathologies.
Assessing
human
status
via
the
measurement
of
rhythms
is
crucial
for
health
management
and
disease
treatment.
Saliva
provides
a
non-invasive
means
such
analysis.
In
this
study,
we
examined
related
parameters
21
healthy
individuals
(
n
=
4
–
19
per
experiment),
assessing
different
data
types,
including
saliva
gene
expression
our
TimeTeller
®
methodology,
hormone
levels,
cell
composition,
self-assessment
tests
chronotype
evaluation.
While
substantial
individual
variability
profiles
was
observed,
found
significant
correlations
between
acrophases
ARNTL1
cortisol,
both
correlated
bedtime
on
sampling
day.
Our
findings
validate
robustness
reliability
method
determining
peripheral
humans,
offering
potential
clinical
applications
diverse
cohorts.
Trends in Pharmacological Sciences,
Journal Year:
2023,
Volume and Issue:
44(10), P. 689 - 704
Published: Aug. 28, 2023
Mood
disorders
account
for
a
significant
global
disease
burden,
and
pharmacological
innovation
is
needed
as
existing
medications
are
suboptimal.
A
wide
range
of
evidence
implicates
circadian
sleep
dysfunction
in
the
pathogenesis
mood
disorders,
there
growing
interest
these
chronobiological
pathways
focus
treatment
innovation.
We
review
contemporary
three
promising
areas
circadian-clock-based
therapeutics
disorders:
targeting
system
informed
by
mechanistic
molecular
advances;
time-tailoring
medications;
personalizing
using
parameters.
also
consider
limitations
challenges
accelerating
development
new
circadian-informed
pharmacotherapies
disorders.
Cell Stress,
Journal Year:
2024,
Volume and Issue:
8, P. 21 - 50
Published: Jan. 1, 2024
The
eight
biological
hallmarks
of
health
that
we
initially
postulated
(Cell.
2021
Jan
7;184(1):33-63)
include
features
spatial
compartmentalization
(integrity
barriers,
containment
local
perturbations),
maintenance
homeostasis
over
time
(recycling
&
turnover,
integration
circuitries,
rhythmic
oscillations)
and
an
array
adequate
responses
to
stress
(homeostatic
resilience,
hormetic
regulation,
repair
regeneration).
These
affect
all
somatic
strata
the
human
body
(molecules,
organelles,
cells,
supracellular
units,
organs,
organ
systems,
systemic
circuitries
meta-organism).
Here
postulate
mental
socioeconomic
factors
must
be
added
this
8×8
matrix
as
additional
hallmark
(“psychosocial
adaptation”)
stratum
interactions”),
hence
building
a
9×9
matrix.
Potentially,
perturbation
each
affects
psychosocial
vice
versa.
Finally,
discuss
(patho)physiological
bases
these
interactions
their
implications
for
improvement.
Journal of Neurosurgical Anesthesiology,
Journal Year:
2024,
Volume and Issue:
36(3), P. 184 - 189
Published: April 29, 2024
Postoperative
delirium
is
one
of
the
most
prevalent
postoperative
complications,
affecting
mostly
older
adults.
Its
incidence
expected
to
rise
because
surgical
advances,
shifting
demographics,
and
increased
life
expectancy.
Although
an
acute
alteration
in
brain
function,
associated
with
adverse
outcomes,
including
progressive
cognitive
decline
dementia,
that
place
significant
burdens
on
patients'
lives
healthcare
systems.
This
has
prompted
efforts
understand
mechanisms
provide
effective
prevention
treatment.
There
are
multiple
involved
etiology
share
similarities
physiological
changes
aging
brain.
In
addition,
patients
often
have
comorbidities
impairment
also
implicated
genesis
delirium.
These
tangled
connections
pinpointed
a
shift
toward
creation
holistic
model
pathophysiology
Scientific
advancements
integrating
clinical
risk
factors,
possible
biomarkers,
genetic
features,
digital
platforms,
other
biotechnical
information
technological
innovations,
will
become
available
near
future.
Advances
artificial
intelligence,
for
example,
aggregate
testing
platforms
patient-specific
stratification
studies,
panels
serum
cerebrospinal
fluid
molecules,
electroencephalogram
signatures,
gut
microbiome
along
integration
novel
polygenetic
variants
sleep
cognition.
advances
allow
enrollment
high-risk
into
programs
help
uncover
new
pharmacologic
targets.
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(6), P. 598 - 598
Published: June 4, 2024
Personalized
sleep
medicine
represents
a
transformative
shift
in
healthcare,
emphasizing
individualized
approaches
to
optimizing
health,
considering
the
bidirectional
relationship
between
and
health.
This
field
moves
beyond
conventional
methods,
tailoring
care
unique
physiological
psychological
needs
of
individuals
improve
quality
manage
disorders.
Key
this
approach
is
consideration
diverse
factors
like
genetic
predispositions,
lifestyle
habits,
environmental
factors,
underlying
health
conditions.
enables
more
accurate
diagnoses,
targeted
treatments,
proactive
management.
Technological
advancements
play
pivotal
role
field:
wearable
devices,
mobile
applications,
advanced
diagnostic
tools
collect
detailed
data
for
continuous
monitoring
analysis.
The
integration
machine
learning
artificial
intelligence
enhances
interpretation,
offering
personalized
treatment
plans
based
on
individual
profiles.
Moreover,
research
circadian
rhythms
physiology
advancing
our
understanding
sleep’s
impact
overall
next
generation
technology
will
integrate
seamlessly
with
IoT
smart
home
systems,
facilitating
holistic
environment
Telemedicine
virtual
healthcare
platforms
increase
accessibility
specialized
care,
especially
remote
areas.
Advancements
also
focus
integrating
various
sources
comprehensive
assessments
treatments.
Genomic
molecular
could
lead
breakthroughs
disorders,
informing
highly
plans.
Sophisticated
methods
stage
estimation,
including
techniques,
are
improving
precision.
Computational
models,
particularly
conditions
obstructive
apnea,
enabling
patient-specific
strategies.
future
likely
involve
cross-disciplinary
collaborations,
cognitive
behavioral
therapy
mental
interventions.
Public
awareness
education
about
approaches,
alongside
updated
regulatory
frameworks
security
privacy,
essential.
Longitudinal
studies
provide
insights
into
evolving
patterns,
further
refining
approaches.
In
conclusion,
revolutionizing
disorder
treatment,
leveraging
characteristics
technologies
improved
diagnosis,
towards
marks
significant
advancement
enhancing
life
those
