Emerging contaminants,
Journal Year:
2024,
Volume and Issue:
10(4), P. 100369 - 100369
Published: May 14, 2024
Microplastic
(MP)
contamination
has
become
a
pervasive
global
issue,
affecting
terrestrial
and
aquatic
environments,
its
potential
health
hazards
are
of
widespread
concern.
This
review
examined
the
intricate
relationship
between
animal
exposure
to
MPs
their
effects,
revealing
that
MP
affects
broad
spectrum
species
across
habitats.
Crucially,
interspecies
differences
in
ingestion,
accumulation,
responses
emerge
as
central
themes
arising
from
various
factors,
including
feeding
behavior,
physiology,
ecological
niches.
The
implications
multifarious;
animals
may
suffer
physical
harm,
endure
chemical
adsorbed
contaminants,
provoke
inflammatory
responses,
undergo
behavioral
modifications.
Chronic
raises
concerns
about
long-term
consequences,
ability
adsorb
transport
chemicals
for
bioaccumulation
pollutants
within
food
webs.
ramifications
profound,
impacting
population
dynamics,
ecosystem
processes.
interplay
underscores
need
interdisciplinary
research
unites
fields
such
biology,
ecology,
chemistry,
toxicology.
Recognizing
effects
significant
implications,
particularly
enter
human
chain
through
on
risks.
Science,
Journal Year:
2023,
Volume and Issue:
379(6639)
Published: March 31, 2023
It
is
known
that
interactions
between
nociceptors
and
dendritic
cells
(DCs)
can
modulate
immune
responses
in
barrier
tissues.
However,
our
understanding
of
the
underlying
communication
frameworks
remains
rudimentary.
Here,
we
show
control
DCs
three
molecularly
distinct
ways.
First,
release
calcitonin
gene-related
peptide
imparts
a
transcriptional
profile
on
steady-state
characterized
by
expression
pro-interleukin-1β
other
genes
implicated
DC
sentinel
functions.
Second,
nociceptor
activation
induces
contact-dependent
calcium
fluxes
membrane
depolarization
enhances
their
production
proinflammatory
cytokines
when
stimulated.
Finally,
nociceptor-derived
chemokine
CCL2
contributes
to
orchestration
DC-dependent
local
inflammation
induction
adaptive
against
skin-acquired
antigens.
Thus,
combined
actions
chemokines,
neuropeptides,
electrical
activity
fine-tune
Bone Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Jan. 5, 2023
Abstract
Skeletal
tissue
is
highly
innervated.
Although
different
types
of
nerves
have
been
recently
identified
in
the
bone,
crosstalk
between
bone
and
remains
unclear.
In
this
review,
we
outline
role
peripheral
nervous
system
(PNS)
regeneration
following
injury.
We
first
introduce
conserved
species
ranging
from
amphibians
to
mammals.
then
present
distribution
PNS
skeletal
under
physiological
conditions,
fractures,
or
regeneration.
Furthermore,
summarize
ways
which
communicates
with
bone-lineage
cells,
vasculature,
immune
cells
microenvironment.
Based
on
comprehensive
timely
conclude
that
regulates
through
neuropeptides
neurotransmitters
nerves.
An
in-depth
understanding
roles
will
inform
development
new
strategies
based
bone-nerve
promoting
repair
Molecular Pain,
Journal Year:
2023,
Volume and Issue:
19
Published: May 23, 2023
Chronic
pain
is
a
refractory
health
disease
worldwide
causing
an
enormous
economic
burden
on
individuals
and
society.
Accumulating
evidence
suggests
that
inflammation
in
the
peripheral
nervous
system
(PNS)
central
(CNS)
major
factor
pathogenesis
of
chronic
pain.
The
early-
late
phase
may
have
distinctive
effects
initiation
resolution
pain,
which
can
be
viewed
as
friend
or
foe.
On
one
hand,
painful
injuries
lead
to
activation
glial
cells
immune
PNS,
releasing
pro-inflammatory
mediators,
contribute
sensitization
nociceptors,
leading
pain;
neuroinflammation
CNS
drives
promotes
development
other
macrophages
PNS
promote
via
anti-inflammatory
mediators
specialized
pro-resolving
(SPMs).
In
this
review,
we
provide
overview
current
understanding
deterioration
Further,
summarize
number
novel
strategies
used
prevent
treat
by
controlling
inflammation.
This
comprehensive
view
relationship
between
its
specific
mechanism
will
targets
for
treatment
Emerging contaminants,
Journal Year:
2024,
Volume and Issue:
10(4), P. 100369 - 100369
Published: May 14, 2024
Microplastic
(MP)
contamination
has
become
a
pervasive
global
issue,
affecting
terrestrial
and
aquatic
environments,
its
potential
health
hazards
are
of
widespread
concern.
This
review
examined
the
intricate
relationship
between
animal
exposure
to
MPs
their
effects,
revealing
that
MP
affects
broad
spectrum
species
across
habitats.
Crucially,
interspecies
differences
in
ingestion,
accumulation,
responses
emerge
as
central
themes
arising
from
various
factors,
including
feeding
behavior,
physiology,
ecological
niches.
The
implications
multifarious;
animals
may
suffer
physical
harm,
endure
chemical
adsorbed
contaminants,
provoke
inflammatory
responses,
undergo
behavioral
modifications.
Chronic
raises
concerns
about
long-term
consequences,
ability
adsorb
transport
chemicals
for
bioaccumulation
pollutants
within
food
webs.
ramifications
profound,
impacting
population
dynamics,
ecosystem
processes.
interplay
underscores
need
interdisciplinary
research
unites
fields
such
biology,
ecology,
chemistry,
toxicology.
Recognizing
effects
significant
implications,
particularly
enter
human
chain
through
on
risks.
