SARS-CoV-2 Delta and Omicron Variants alter Trophoblast Cell Fusion and Syncytiotrophoblast Dynamics: New Insights into Placental Vulnerability DOI
Marie Cohen, Manel Essaidi-Laziosi,

Catia Alvarez

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Pregnancy constitutes an at-risk factor for severe COVID-19. Several clinical studies have previously suggested increased risks of adverse obstetrical outcomes and placental pathological changes in pregnant women infected with SARS-CoV-2. In this study, our goal was to assess the susceptibility trophoblast SARS-CoV-2 infection at early stage pregnancy its impact on cell fusion in vitro. We showed that first trimester cytotrophoblast (CTB) syncytiotrophoblast (STB) are permissive variant- donor-dependent manner. Delta variant a higher efficiency replication STB CTB compared Omicron BA.1, BA.2 BA.5. STB, despite slight subsequent increase type III IFN response, no correlation observed between virus induction overall host response (including expression entry receptors immune response) after infection. CTB, significantly correlated level leading syncytia formation. line formation vitro, we vivo syncytial knots release placenta by both SARS-CoV-2- negative areas from same placenta, age matched references. Altogether, vitro data efficient variants cells during might alter turnover.

Language: Английский

The therapeutic age of the neonatal Fc receptor DOI Open Access
Michał Pyzik, Lisa K. Kozicky, Amit Gandhi

et al.

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(7), P. 415 - 432

Published: Feb. 1, 2023

Language: Английский

Citations

110
Local immune recognition of trophoblast in early human pregnancy: controversies and questions DOI Open Access
Ashley Moffett,

Norman Shreeve

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(4), P. 222 - 235

Published: Oct. 3, 2022

Language: Английский

Citations

67
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy DOI Creative Commons
Mary Prahl, Yarden Golan, Arianna G. Cassidy

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 30, 2022

Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, levels protection provided their newborns through placental transfer antibodies. Here, we transplacental vaccine products functional anti-SARS-CoV-2 antibodies pregnancy early infancy in a cohort 20 individuals vaccinated late pregnancy. We find no evidence maternal blood, placenta tissue, or cord blood at delivery. However, time-dependent efficient IgG neutralizing neonate that persists infancy. Additionally, using phage immunoprecipitation sequencing, vaccine-specific signature Spike protein epitope binding is transplacentally transferred Timing critical ensure protective

Language: Английский

Citations

50
Natural Killer Cells in the Human Uterine Mucosa DOI Creative Commons
Victoria Male, Ashley Moffett

Annual Review of Immunology, Journal Year: 2023, Volume and Issue: 41(1), P. 127 - 151

Published: Jan. 11, 2023

The presence of granulated lymphocytes in the human uterine mucosa, known as decidua during pregnancy, or endometrium otherwise, was first noted nineteenth century, but it not until 1990 that these cells were identified a type natural killer (NK) cell. From outset, NK (uNK) found to be less cytotoxic than their circulating counterparts, peripheral (pNK) cells. Recently, unbiased approaches have defined three subpopulations uNK cells, all which cluster separately from pNK Here, we review history research into including ability interact with placental extravillous trophoblast and potential role regulating implantation. We go on more recent advances focus cell development heterogeneity defend against infection mediate memory effects. Finally, consider how better understanding could leveraged future improve outcomes pregnancy for mothers babies.

Language: Английский

Citations

23
Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases DOI
Zhongyan Wang,

Hongjing Luo,

Heping Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(25)

Published: Feb. 21, 2024

Abstract Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines based on peptide or derivatives self‐assembly that are constructed in vitro vivo. Benefiting from the inherent advantages of peptides, such as good biocompatibility, high bioactivity, and flexible tunability, reported PST have shown excellent application prospects combating many major diseases including cancer, cardiovascular disease, infectious autoimmune metabolic so on. Through thoughtful design, can be fabricated various forms, self‐assembled precursor molecules, functional nano‐assemblies, macroscopic large‐scale hydrogels. The involved peptides play different roles, serving drug carriers for effective delivery, acting scaffold materials cell culture, functioning bioactive sequences treating diseases. In this review, a comprehensive overview traditional strategies is provided build emphasize their therapeutic applications fighting pose threat human life health. Moreover, main challenges systems application, clinical translation also briefly discussed. It hoped review arouse much more attention paid promote its practical biomedical field.

Language: Английский

Citations

13
Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study DOI Creative Commons
Fernando C. Barros, Robert B. Gunier,

Albertina Rego

et al.

American Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 231(4), P. 460.e1 - 460.e17

Published: Feb. 16, 2024

Language: Английский

Citations

12
A review on Zika vaccine development DOI Creative Commons

Zhe‐Yu Peng,

Yang Song,

Hong‐Zheng Lu

et al.

Pathogens and Disease, Journal Year: 2024, Volume and Issue: 82

Published: Jan. 1, 2024

Abstract Zika virus (ZIKV), which belongs to the Flavivirus family, is mainly transmitted via bite of Aedes mosquitoes. In newborns, ZIKV infection can cause severe symptoms such as microcephaly, while in adults, it lead Guillain‒Barré syndrome (GBS). Due lack specific therapeutic methods against ZIKV, development a safe and effective vaccine extremely important. Several potential vaccines, live attenuated, inactivated, nucleic acid, viral vector, recombinant subunit have demonstrated promising outcomes clinical trials involving human participants. Therefore, this review, recent developmental progress, advantages disadvantages these five types are examined, practical recommendations for future provided.

Language: Английский

Citations

9
The influence of COVID-19 infection-associated immune response on the female reproductive system DOI Open Access

Mariam Saadedine,

Malak El Sabeh, Mostafa A. Borahay

et al.

Biology of Reproduction, Journal Year: 2022, Volume and Issue: 108(2), P. 172 - 182

Published: Sept. 29, 2022

Abstract Coronavirus disease 2019 (COVID-19) is a multi-system that has led to pandemic with unprecedented ramifications. The challenged scientists for the past 2 years and brought back previously abandoned research topics. COVID-19 infection causes myriad of symptoms ranging from mild flu-like severe illness requiring hospitalization. Case reports showed multiple systemic effects infection, including acute respiratory distress syndrome, fibrosis, colitis, thyroiditis, demyelinating syndromes, mania, indicating can affect most human body systems. Unsurprisingly, major concern women all over globe whether any long-term on their menstrual cycle, fertility, or pregnancy. Published data have suggested an effect reproductive health, we hypothesize reported adverse are due robust immune reaction against associated cytokine storm. While receptor (angiotensin converting enzyme, ACE2) expressed in ovaries, uterus, vagina, placenta, it plays less important role system. Cytokines glucocorticoids act hypothalamo–pituitary gonadal axis, arachidonic acid pathways, which leads disturbances pregnancy-related events such as preterm labor miscarriages. This hypothesis further supported by apparent lack health females, when storm its dampened, no longer affected.

Language: Английский

Citations

29
Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy DOI Creative Commons
Dingning Zhang, Ting‐Ting Huang, Zhihui Chen

et al.

Pediatric Research, Journal Year: 2023, Volume and Issue: 94(1), P. 34 - 42

Published: Jan. 3, 2023

Abstract Background The safety of coronavirus disease 2019 (COVID-19) vaccines during pregnancy is a particular concern. Here, we addressed the neonatal outcomes after maternal vaccination COVID-19 pregnancy. Methods We systematically searched PubMed, EMBASE, and WHO Database for studies on from inception to 3 July 2022. Main were related preterm, small gestation (SGA), NICU admission, low Apgar score at 5 min (<7), additional such as <34 weeks, birth weight some morbidity all also analyzed. Results A total 15 included. found that was reduction rates Preterm, SGA, Low (<7). In addition, there no evidence higher risk adverse pregnancy, including preterm with weight, very congenital anomalies, so on. Conclusions in pregnant women does not raise significant effects protective effect outcomes. Impact Present study has present could encourage be vaccinated against COVID-19.

Language: Английский

Citations

21
Maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization DOI Open Access
Michal Lipschuetz, Joshua Guedalia, S. M. Cohen

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(5), P. 1155 - 1163

Published: March 23, 2023

Language: Английский

Citations

18