DNA origami

Nature Reviews Methods Primers, Journal Year: 2021, Volume and Issue: 1(1)

Published: Jan. 28, 2021

Language: Английский

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Supramolecular cancer nanotheranostics

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(4), P. 2839 - 2891

Published: Jan. 1, 2021

Supramolecular cancer nanotheranostics have shown promising potentials in early-stage diagnosis and personal therapy. Herein, we summarize the progress of supramolecular provide guidance for designing new targeted theranostic agents.

Language: Английский

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Molecular imaging and disease theranostics with renal-clearable optical agents

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 1095 - 1113

Published: June 23, 2021

Language: Английский

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Nanomedicine in cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Aug. 7, 2023

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.

Language: Английский

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Cancer nanomedicine

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(10), P. 550 - 556

Published: Aug. 8, 2022

Language: Английский

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Current approaches of nanomedicines in the market and various stage of clinical translation

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(7), P. 3028 - 3048

Published: March 1, 2022

Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review provides a snapshot of that have been currently launched or in the clinical trials, which manifests diversified trend carrier types, applied indications mechanisms action. From perspective indications, this article presents an overview applications involving prevention, diagnosis treatment various diseases, include cancer, infections, blood disorders, cardiovascular immuno-associated diseases nervous system etc. Moreover, some considerations perspectives research development facilitate their translations clinic.

Language: Английский

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Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

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Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption

ACS Nano, Journal Year: 2021, Volume and Issue: 15(7), P. 11066 - 11086

Published: July 12, 2021

Electrical stimulation has shown great promise in biomedical applications, such as regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical end effectors electrodes requires connectors batteries, which dramatically hamper translation technologies several scenarios. Piezoelectric nanomaterials can overcome limitations current procedures they be wirelessly activated by external energy sources ultrasound. Wireless mediated piezoelectric nanoarchitectures constitutes an innovative paradigm enabling induction cues within body a localized, wireless, minimally invasive fashion. In this review, we highlight fundamental mechanisms acoustically its applications area. adoption technology clinical practice is infancy, open issues, properties measurement, control ultrasound dose vitro, modeling measurement piezo effects, knowledge on triggered bioeffects, therapy targeting, biocompatibility studies, delivered vivo, must addressed. This article explores challenges proposes strategies that may guide future research efforts field toward to scene.

Language: Английский

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Cancer nanotechnology: current status and perspectives

Nano Convergence, Journal Year: 2021, Volume and Issue: 8(1)

Published: Nov. 2, 2021

Modern medicine has been waging a war on cancer for nearly century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase specificity and decrease systemic toxicities remains. Early diagnosis holds key improving prognostic outlook patient quality of life, diagnostic tools are cusp technological revolution. Nanotechnology steadily expanded into reaches chemotherapy, radiotherapy, diagnostics, imaging, demonstrating capacity augment each advance care. Nanomaterials provide an abundance versatility, functionality, applications engineer specifically targeted medicine, accurate early-detection devices, robust imaging modalities, enhanced radiotherapy adjuvants. This review provides insights current clinical pre-clinical nanotechnological drug therapy, radiation therapy.

Language: Английский

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Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(7), P. 943 - 943

Published: June 24, 2021

The use of magnetism in medicine has changed dramatically since its first application by the ancient Greeks 624 BC. Now, leveraging magnetic nanoparticles, investigators have developed a range modern applications that external fields to manipulate biological systems. Drug delivery systems incorporate these particles can target therapeutics specific tissues without need for or chemical cues. Once precisely located within an organism, nanoparticles be heated oscillating fields, which results localized inductive heating used thermal ablation more subtle cellular manipulation. Biological imaging also improved using as contrast agents; several types iron oxide are US Food and Administration (FDA)-approved resonance (MRI) agents improve image resolution information content. New modalities, such particle (MPI), directly detect organisms, allowing background-free transport collection. "Lab-on-a-chip" technology benefits from increased control provide over separation, leading separation. Magnetic separation is becoming important next-generation immunoassays, both increase sensitivity enable multiple analyte detection. More recently, ability material motion with been applied magnetically actuated soft robotics designed biomedical interventions. In this review article, origins various areas introduced, followed discussion current clinical applications, well emerging trends study materials.

Language: Английский

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