Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(15)
Published: March 26, 2023
Abstract
The
regulation
of
tumor
immunosuppressive
microenvironments
via
precise
drug
delivery
is
a
promising
strategy
for
preventing
recurrence
and
metastasis.
Inspired
by
the
stealth
strategy,
stealthy
nanovehicle
based
on
neutrophil
camouflage
developed
to
achieve
immunotherapy
triggering
pyroptosis.
comprises
anti‐CD11b‐
IR820‐conjugated
bovine
serum
albumin
nanoparticles
loaded
with
decitabine.
Camouflaged
neutrophils,
nanovehicles
efficient
hitchhiking
owing
biotropism
neutrophils
tumors.
fluorescent
signal
molecule,
IR820,
acts
as
navigation
monitor
track
nanovehicle.
released
decitabine
upregulates
gasdermin
E,
laser
irradiation
activates
caspase‐3,
thereby
resulting
in
pyroptosis,
which
improves
system's
adaptive
immune
response.
In
triple‐negative
breast
cancer
animal
model,
it
regulates
microenvironment
effective
induces
long‐lasting
strong
memory
prevent
lung
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(25)
Published: March 4, 2023
Metallomodulation
cell
death
strategies
are
extensively
investigated
for
antitumor
therapy,
such
as
cuproptosis,
ferroptosis,
and
chemodynamic
therapy
(CDT).
Undoubtedly,
the
accurate
specific
elevation
of
metal
ions
levels
in
cancer
cells
is
key
to
boosting
their
therapeutic
index.
Herein,
a
programmably
controllable
delivery
system
based
on
croconium
dye
(Croc)-ferrous
ion
(Fe2+
)
nanoprobes
(CFNPs)
developed
multiscale
dynamic
imaging
guided
photothermal
primed
CDT.
The
Croc,
with
kinds
electron-rich
iron-chelating
groups,
can
form
Croc-Fe2+
complex
precise
stoichiometry
1:1
steadily
maintain
valence
state
Fe2+
.
CFNPs
achieve
pH-responsive
visualization
release
cancerous
tissues
under
coactivation
"dual-key"
stimulation
"acidity
near-infrared
(NIR)
light".
acidic
tumor
microenvironment
actuates
NIR
fluorescence/photoacoustic
properties
CFNPs.
Sequentially,
exogenous
light,
enable
vivo
release,
thus
achieving
CDT
tumors.
By
leveraging
technologies,
complicated
spatiotemporal
sketched
manner,
domino
effect
pH
level,
effect,
also
revealed,
endowing
customized
feedback
panorama
within
disease
microenvironment.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(25), P. 14155 - 14163
Published: June 16, 2023
Although
proteolysis
targeting
chimeras
(PROTACs)
have
become
promising
therapeutic
modalities,
important
concerns
exist
about
the
potential
toxicity
of
approach
owing
to
uncontrolled
degradation
proteins
and
undesirable
ligase-mediated
off-target
effects.
Precision
manipulation
activity
PROTACs
could
minimize
side
As
a
result,
extensive
efforts
been
devoted
developing
cancer
biomarker
activating
prodrugs
PROTACs.
In
this
investigation,
we
developed
bioorthogonal
on-demand
prodrug
strategy
(termed
click-release
"crPROTACs")
that
enables
on-target
activation
PROTAC
release
in
cells
selectively.
Inactive
TCO-ARV-771
TCO-DT2216
are
rationally
designed
by
conjugating
trans-cyclooctenes
(TCO)
group
into
ligand
VHL
E3
ubiquitin
ligase.
The
tetrazine
(Tz)-modified
RGD
peptide,
c(RGDyK)-Tz,
which
targets
integrin
αvβ3
cells,
serves
as
component
for
achieve
targeted
interest
(POIs)
versus
noncancerous
normal
cells.
results
studies
accessing
viability
show
selectively
activated
an
αvβ3-dependent
manner
produce
PROTACs,
degrade
POIs
crPROTAC
might
be
general,
abiotic
induce
selective
cell
death
through
ubiquitin-proteasome
pathway.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 1, 2023
Zein,
as
one
of
the
natural
and
GRAS
proteins
in
plant,
is
renewable,
nontoxic,
biocompatible
biodegradable.
Over
past
decade,
many
research
efforts
have
been
devoted
to
zein-based
biomaterials
for
several
industrial
applications.
Combining
with
experiences
our
group,
preparation
methods,
characterizations
pharmaceutical
applications
nanoparticles
were
summarized
this
review.
Zein
NPs
different
particle
nanostructures
prepared
by
chemical
crosslinking,
desolvating,
dispersing
micromixing
strategies.
The
zein
are
mainly
focus
on
drug
delivery.
can
improve
stability,
increase
oral
bioavailability,
control
release
enhance
targeting,
thereby
improving
effect
effectively.
More
required
analyze
relationship
among
properties
virtue
quality
design
approach,
further
promote
scale-up
production
clinical
application
NPs.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(15)
Published: March 26, 2023
Abstract
The
regulation
of
tumor
immunosuppressive
microenvironments
via
precise
drug
delivery
is
a
promising
strategy
for
preventing
recurrence
and
metastasis.
Inspired
by
the
stealth
strategy,
stealthy
nanovehicle
based
on
neutrophil
camouflage
developed
to
achieve
immunotherapy
triggering
pyroptosis.
comprises
anti‐CD11b‐
IR820‐conjugated
bovine
serum
albumin
nanoparticles
loaded
with
decitabine.
Camouflaged
neutrophils,
nanovehicles
efficient
hitchhiking
owing
biotropism
neutrophils
tumors.
fluorescent
signal
molecule,
IR820,
acts
as
navigation
monitor
track
nanovehicle.
released
decitabine
upregulates
gasdermin
E,
laser
irradiation
activates
caspase‐3,
thereby
resulting
in
pyroptosis,
which
improves
system's
adaptive
immune
response.
In
triple‐negative
breast
cancer
animal
model,
it
regulates
microenvironment
effective
induces
long‐lasting
strong
memory
prevent
lung
