Periodontology 2000,
Journal Year:
2021,
Volume and Issue:
86(1), P. 210 - 230
Published: March 10, 2021
Abstract
In
health,
indigenous
polymicrobial
communities
at
mucosal
surfaces
maintain
an
ecological
balance
via
both
inter‐microbial
and
host‐microbial
interactions
that
promote
their
own
the
host's
fitness,
while
preventing
invasion
by
exogenous
pathogens.
However,
genetic
acquired
destabilizing
factors
(including
immune
deficiencies,
immunoregulatory
defects,
smoking,
diet,
obesity,
diabetes
other
systemic
diseases,
aging)
may
disrupt
this
homeostatic
balance,
leading
to
selective
outgrowth
of
species
with
potential
for
destructive
inflammation.
This
process,
known
as
dysbiosis,
underlies
development
periodontitis
in
susceptible
hosts.
The
pathogenic
process
is
not
linear
but
involves
a
positive‐feedback
loop
between
dysbiosis
host
inflammatory
response.
dysbiotic
community
essentially
quasi‐organismal
entity,
where
constituent
organisms
communicate
sophisticated
physical
chemical
signals
display
functional
specialization
(eg,
accessory
pathogens,
keystone
pathobionts),
which
enables
synergy
dictates
community's
or
nososymbiocity.
review,
we
discuss
early
recent
studies
support
model
periodontal
disease
pathogenesis.
According
concept,
caused
individual
“causative
pathogens”
rather
reciprocally
reinforced
physically
metabolically
integrated
dysregulated
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: April 23, 2022
Abstract
The
role
of
microbiota
in
health
and
diseases
is
being
highlighted
by
numerous
studies
since
its
discovery.
Depending
on
the
localized
regions,
can
be
classified
into
gut,
oral,
respiratory,
skin
microbiota.
microbial
communities
are
symbiosis
with
host,
contributing
to
homeostasis
regulating
immune
function.
However,
dysbiosis
lead
dysregulation
bodily
functions
including
cardiovascular
(CVDs),
cancers,
respiratory
diseases,
etc.
In
this
review,
we
discuss
current
knowledge
how
links
host
or
pathogenesis.
We
first
summarize
research
healthy
conditions,
gut-brain
axis,
colonization
resistance
modulation.
Then,
highlight
pathogenesis
disease
development
progression,
primarily
associated
community
composition,
modulation
response,
induction
chronic
inflammation.
Finally,
introduce
clinical
approaches
that
utilize
for
treatment,
such
as
fecal
transplantation.
Periodontology 2000,
Journal Year:
2021,
Volume and Issue:
87(1), P. 107 - 131
Published: Aug. 31, 2021
Abstract
States
of
oral
health
and
disease
reflect
the
compositional
functional
capacities
of,
as
well
interspecies
interactions
within,
microbiota.
The
cavity
exists
a
highly
dynamic
microbial
environment
that
harbors
many
distinct
substrata
microenvironments
house
diverse
communities.
Specific
to
cavity,
nonshedding
dental
surfaces
facilitate
development
complex
polymicrobial
biofilm
communities,
characterized
not
only
by
microbes
comprising
them,
but
cumulatively
their
activities.
Adding
this
complexity,
faces
near‐constant
environmental
challenges,
including
those
from
host
diet,
salivary
flow,
masticatory
forces,
introduction
exogenous
microbes.
composition
microbiome
is
shaped
throughout
life
factors
genetics,
maternal
transmission,
factors,
such
dietary
habits,
hygiene
practice,
medications,
systemic
factors.
This
ecosystem
presents
opportunities
for
dysbiosis
periodontal
diseases.
application
both
in
vitro
culture‐independent
approaches
has
broadened
mechanistic
understandings
communities
within
environmental,
local,
underpinnings
influence
dynamics
microbiome.
Here,
we
review
present
knowledge
current
understanding
influences
challenges
upon
system
encourage
homeostasis
or
provoke
perturbation,
thus
contribute
states
disease.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1614 - 1614
Published: June 19, 2023
Biofilm
is
complex
and
consists
of
bacterial
colonies
that
reside
in
an
exopolysaccharide
matrix
attaches
to
foreign
surfaces
a
living
organism.
frequently
leads
nosocomial,
chronic
infections
clinical
settings.
Since
the
bacteria
biofilm
have
developed
antibiotic
resistance,
using
antibiotics
alone
treat
brought
on
by
ineffective.
This
review
provides
succinct
summary
theories
behind
composition
of,
formation
drug-resistant
attributed
cutting-edge
curative
approaches
counteract
biofilm.
The
high
frequency
medical
device-induced
due
warrants
application
innovative
technologies
manage
complexities
presented
Technology in Cancer Research & Treatment,
Journal Year:
2019,
Volume and Issue:
18
Published: Jan. 1, 2019
Despite
advancement
in
cancer
treatment,
oral
has
a
poor
prognosis
and
is
often
detected
at
late
stage.
To
overcome
these
challenges,
investigators
should
search
for
early
diagnostic
prognostic
biomarkers.
More
than
700
bacterial
species
reside
the
cavity.
The
microbiome
population
varies
by
saliva
different
habitats
of
Tobacco,
alcohol,
betel
nut,
which
are
causative
factors
cancer,
may
alter
composition.
Both
pathogenic
commensal
strains
bacteria
have
significantly
contributed
to
cancer.
Numerous
cavity
involved
chronic
inflammation
that
lead
development
carcinogenesis.
Bacterial
products
its
metabolic
by-products
induce
permanent
genetic
alterations
epithelial
cells
host
drive
proliferation
and/or
survival
cells.
Porphyromonas
gingivalis
Fusobacterium
nucleatum
production
inflammatory
cytokines,
cell
proliferation,
inhibition
apoptosis,
cellular
invasion,
migration
thorough
genomic
alterations.
Recent
metagenomic
technologies
be
useful
identifying
cancer–related
microbiome,
their
genomes,
virulence
properties,
interaction
with
immunity.
It
very
important
address
responsible
driving
Alteration
microbial
communities
potential
application
as
tool
predict
squamous
carcinoma.
Clinicians
aware
protective
properties
resident
microflora
beneficial
define
treatment
strategies.
develop
highly
precise
effective
therapeutic
approaches,
identification
specific
microbiomes
required.
In
this
review,
we
narrate
role
progression
an
biomarker
Periodontology 2000,
Journal Year:
2020,
Volume and Issue:
84(1), P. 14 - 34
Published: Aug. 25, 2020
Abstract
Recent
advances
indicate
that
periodontitis
is
driven
by
reciprocally
reinforced
interactions
between
a
dysbiotic
microbiome
and
dysregulated
inflammation.
Inflammation
not
only
consequence
of
dysbiosis
but,
via
mediating
tissue
dysfunction
damage,
fuels
further
growth
selectively
communities
bacteria
(inflammophiles),
thereby
generating
self‐sustained
feed‐forward
loop
perpetuates
the
disease.
These
considerations
provide
strong
rationale
for
developing
adjunctive
host‐modulation
therapies
treatment
periodontitis.
Such
approaches
aim
to
inhibit
harmful
inflammation
promote
its
resolution
or
interfere
directly
with
downstream
effectors
connective
bone
destruction.
This
paper
reviews
diverse
strategies
targeted
modulate
host
periodontal
response
discusses
their
mechanisms
action,
perceived
safety,
potential
clinical
application.
