The Journal of Experimental Medicine,
Journal Year:
2023,
Volume and Issue:
220(9)
Published: June 1, 2023
Neutrophil
infiltration
is
a
hallmark
of
periodontitis,
prevalent
oral
inflammatory
condition
in
which
Th17-driven
mucosal
inflammation
leads
to
destruction
tooth-supporting
bone.
Herein,
we
document
that
neutrophil
extracellular
traps
(NETs)
are
early
triggers
pathogenic
periodontitis.
In
an
established
animal
model,
demonstrate
neutrophils
infiltrate
the
gingival
mucosa
at
time
points
after
disease
induction
and
expel
NETs
trigger
bone
vivo.
Investigating
mechanisms
by
drive
loss,
find
histones,
major
component
NETs,
upregulation
IL-17/Th17
responses,
destruction.
Importantly,
human
findings
corroborate
our
experimental
work.
We
significantly
increased
levels
NET
complexes
histones
bearing
classic
NET-associated
posttranslational
modifications,
blood
local
lesions
severe
periodontitis
patients,
absence
confounding
disease.
Our
suggest
feed-forward
loop
IL-17
immunity
promote
immunopathology
Periodontology 2000,
Journal Year:
2022,
Volume and Issue:
89(1), P. 9 - 18
Published: March 4, 2022
Abstract
Periodontitis,
a
microbiome‐driven
inflammatory
disease
of
the
tooth‐attachment
apparatus,
is
epidemiologically
linked
with
other
disorders,
including
cardio‐metabolic,
cognitive
neurodegenerative
and
autoimmune
diseases,
respiratory
infections,
certain
cancers.
These
associations
may,
in
part,
be
causal,
as
suggested
by
interventional
studies
showing
that
local
treatment
periodontitis
reduces
systemic
inflammation
surrogate
markers
comorbid
diseases.
The
potential
cause‐and‐effect
connection
between
comorbidities
corroborated
preclinical
models
disease,
which
additionally
provided
mechanistic
insights
into
these
associations.
This
overview
discusses
recent
advances
our
understanding
periodontitis‐systemic
connection,
may
potentially
lead
to
innovative
therapeutic
options
reduce
risk
periodontitis‐linked
comorbidities.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2021,
Volume and Issue:
11
Published: Dec. 7, 2021
Periodontal
disease
is
classically
characterized
by
progressive
destruction
of
the
soft
and
hard
tissues
periodontal
complex,
mediated
an
interplay
between
dysbiotic
microbial
communities
aberrant
immune
responses
within
gingival
tissues.
Putative
pathogens
are
enriched
as
resident
oral
microbiota
becomes
inflammatory
evoke
tissue
destruction,
thus
inducing
unremitting
positive
feedback
loop
proteolysis,
inflammation,
enrichment
for
pathogens.
Keystone
sustained
inflammation
critical
to
progression.
However,
recent
studies
have
revealed
importance
previously
unidentified
microbes
involved
in
progression,
including
various
viruses,
phages
bacterial
species.
Moreover,
newly
identified
immunological
genetic
mechanisms,
well
environmental
host
factors,
diet
lifestyle,
been
discerned
years
further
contributory
factors
periodontitis.
These
collectively
expanded
established
narrative
In
line
with
this,
new
ideologies
related
maintaining
health
treating
existing
explored,
such
application
probiotics,
limit
attenuate
The
role
systemic
pathologies,
autoimmune
disorders
diabetes,
pathogenesis
has
noted.
Recent
additionally
reciprocated
potentiating
states
at
distal
sites,
Alzheimer’s
disease,
bowel
diseases,
cancer,
highlighting
cavity
health.
Here
we
review
long-standing
knowledge
progression
while
integrating
novel
research
concepts
that
broadened
our
understanding
disease.
Further,
delve
into
innovative
hypotheses
may
evolve
address
significant
gaps
foundational
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(37), P. 15427 - 15439
Published: Sept. 13, 2021
Traditional
surgical
intervention
and
antibiotic
treatment
are
poor
even
invalid
for
chronic
diseases
including
periodontitis
induced
by
diverse
oral
pathogens,
which
often
causes
progressive
destruction
of
tissues,
tooth
loss,
systemic
diseases.
Herein,
an
ointment
comprising
atomic-layer
Fe2O3-modified
two-dimensional
porphyrinic
metal–organic
framework
(2D
MOF)
nanosheets
is
designed
incorporating
a
polyethylene
glycol
matrix.
After
the
atomic
layer
deposition
surface
engineering,
enhanced
photocatalytic
activity
2D
MOF
heterointerface
results
from
lower
adsorption
energy
more
charge
transfer
amounts
due
to
synergistic
effect
metal–linker
bridging
units,
abundant
active
sites,
excellent
light-harvesting
network.
This
biocompatible
biodegradable
MOF-based
heterostructure
exhibits
broad-spectrum
antimicrobial
(99.87
±
0.09%,
99.57
0.21%,
99.03
0.24%)
against
pathogens
(Porphyromonas
gingivalis,
Fusobacterium
nucleatum,
Staphylococcus
aureus)
reactive
oxygen
species
released
ions.
photodynamic
ion
therapy
superior
therapeutic
reported
clinical
owing
rapid
antibacterial
activity,
alleviative
inflammation,
improved
angiogenesis.
Journal Of Clinical Periodontology,
Journal Year:
2022,
Volume and Issue:
49(S24), P. 4 - 71
Published: June 1, 2022
Abstract
Background
The
recently
published
clinical
practice
guideline
(CPG)
for
the
treatment
of
periodontitis
in
stages
I–III
provided
evidence‐based
recommendations
patients,
defined
according
to
2018
classification.
Stage
IV
shares
severity
and
complexity
characteristics
stage
III
periodontitis,
but
includes
anatomical
functional
sequelae
tooth
periodontal
attachment
loss
(tooth
flaring
drifting,
bite
collapse,
etc.),
which
require
additional
interventions
following
completion
active
therapy.
Aim
To
develop
an
S3
Level
CPG
focusing
on
implementation
inter‐disciplinary
approaches
required
treat/rehabilitate
patients
associated
loss.
Materials
Methods
This
was
developed
by
European
Federation
Periodontology
(EFP),
methodological
guidance
from
Association
Scientific
Medical
Societies
Germany
Grading
Recommendations
Assessment,
Development
Evaluation
(GRADE)
process.
A
rigorous
transparent
process
included
synthesis
relevant
research
13
specifically
commissioned
systematic
reviews,
evaluation
quality
strength
evidence,
formulation
specific
a
structured
consensus
with
leading
experts
broad
base
stakeholders.
Results
culminated
different
interventions,
including
orthodontic
movement,
splinting,
occlusal
adjustment,
tooth‐
or
implant‐supported
fixed
removable
dental
prostheses
supportive
care.
Prior
planning,
it
is
critically
important
undertake
definitive
comprehensive
diagnosis
case
evaluation,
obtain
patient
information,
engage
frequent
re‐evaluations
during
after
treatment.
component
therapy
should
follow
I–III.
Conclusions
present
informs
practice,
health
systems,
policymakers
and,
indirectly,
public
available
most
effective
modalities
treat
maintain
healthy
dentition
over
lifetime,
evidence
at
time
publication.
