The diverse roles of DNA methylation in mammalian development and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(10), P. 590 - 607

Published: Aug. 9, 2019

Language: Английский

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Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: Nov. 24, 2020

Abstract Wnt signaling is a highly conserved pathway that plays critical role in controlling embryonic and organ development, as well cancer progression. Genome-wide sequencing gene expression profile analyses have demonstrated involved mainly the processes of breast proliferation metastasis. The most recent studies indicated also crucial immune microenvironment regulation, stemness maintenance, therapeutic resistance, phenotype shaping, etc. Wnt/β-Catenin, Wnt–planar cell polarity (PCP), Wnt–Ca 2+ are three well-established pathways share overlapping components play different roles In this review, we summarize main findings concerning relationship between provide an overview existing mechanisms, challenges, potential opportunities for advancing therapy diagnosis cancer.

Language: Английский

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Molecular mechanisms of transgenerational epigenetic inheritance

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(6), P. 325 - 341

Published: Jan. 4, 2022

Language: Английский

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Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

MedComm, Journal Year: 2023, Volume and Issue: 4(4)

Published: July 14, 2023

Nanoparticles (NPs) have become one of the most popular objects scientific study during past decades. However, despite wealth reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding NPs risk effects. In this review, we first present comprehensive landscape applications on health, especially addressing role medical diagnosis, therapy. Then, toxicity systems introduced. We describe detail effects various systems, including respiratory, nervous, endocrine, immune, reproductive carcinogenicity NPs. Furthermore, unravels mechanisms ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA cell cycle, epigenetic regulation. addition, classical such as lines mice emerging 3D organoids used for evaluating or are both Overall, review presents critical summary state NPs, giving readers more better remedy key gaps knowledge techniques.

Language: Английский

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Sperm RNA code programmes the metabolic health of offspring

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(8), P. 489 - 498

Published: June 24, 2019

Language: Английский

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Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health

Human Reproduction Update, Journal Year: 2019, Volume and Issue: 25(5), P. 519 - 541

Published: April 8, 2019

A defining feature of sexual reproduction is the transmission genomic information from both parents to offspring. There now compelling evidence that inheritance such genetic accompanied by additional epigenetic marks, or stable heritable not accounted for variations in DNA sequence. The reversible nature marks coupled with multiple rounds reprogramming erase majority existing patterns have made investigation this phenomenon challenging. However, continual advances molecular methods are allowing closer examination dynamic alterations histone composition and methylation accompany development and, particular, how these modifications can occur an individual's germline be transmitted following generation. While underlying mechanisms permit form transgenerational remain unclear, it increasingly apparent a combination plays major roles determining phenotypes individuals their offspring.Information pertaining was systematically reviewed focusing primarily on mammalian cells exclusion plants, due inherent differences means which between generations. effects environmental factors biological processes were determine contribution modulating inheritable phenotypes.Articles indexed PubMed searched using keywords related inheritance, modifications, paternal maternal traits influencing modifications. We sought clarify role events during life cycle mammals provide comprehensive review epigenomic make-up progenitors may phenotype its descendants.We found strong supporting patterns, even non-protein-coding RNA altering producing offspring, humans rodent species. Multiple domains several modification sites resist demethylation endure genome-wide events. Epigenetic integrated into genome shown modulate gene expression activity at enhancer promoter domains, while mutations alter sequence availability binding. Fundamentally, nuclear response factors, ageing, diet toxicant exposure potential become hereditably transmitted.The environment influences health well-being progeny working through introduce spontaneous as well variety changes, including status post-translational histones. In evolutionary terms, changes create phenotypic diversity fuels fires natural selection. rather than being adaptive, variation also generate plethora pathological disease states ranging dominant disorders neurological conditions, schizophrenia autism.

Language: Английский

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Insights into epigenetic patterns in mammalian early embryos

Protein & Cell, Journal Year: 2020, Volume and Issue: 12(1), P. 7 - 28

Published: July 15, 2020

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to formation a totipotent embryo. During development pre-implantation embryo, precise reprogramming progress is prerequisite for avoiding developmental defects or embryonic lethality, but underlying molecular mechanisms remain elusive. For past few years, unprecedented breakthroughs have been made in mapping regulatory network dynamic epigenomes during mammalian early embryo development, taking advantage multiple advances and innovations low-input genome-wide chromatin analysis technologies. The aim this review highlight most recent understanding embryogenesis mammals, including DNA methylation, histone modifications, accessibility 3D organization.

Language: Английский

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Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice

Cell, Journal Year: 2023, Volume and Issue: 186(4), P. 715 - 731.e19

Published: Feb. 1, 2023

Language: Английский

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Epigenetic inheritance of polycystic ovary syndrome — challenges and opportunities for treatment

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(9), P. 521 - 533

Published: July 7, 2021

Language: Английский

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Regulation, functions and transmission of bivalent chromatin during mammalian development

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(1), P. 6 - 26

Published: Aug. 26, 2022

Language: Английский

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