Cells,
Journal Year:
2024,
Volume and Issue:
13(2), P. 138 - 138
Published: Jan. 11, 2024
A
multitude
of
physiological
processes,
human
behavioral
patterns,
and
social
interactions
are
intricately
governed
by
the
complex
interplay
between
external
circumstances
endogenous
circadian
rhythms.
This
multidimensional
regulatory
framework
is
susceptible
to
disruptions,
in
contemporary
society,
there
a
prevalent
occurrence
misalignments
system
environmental
cues,
phenomenon
frequently
associated
with
adverse
health
consequences.
The
onset
most
current
chronic
diseases
intimately
connected
alterations
lifestyle
practices
under
various
facets,
including
following:
reduced
physical
activity,
exposure
artificial
light,
also
acknowledged
as
light
pollution,
sedentary
behavior
coupled
consuming
energy-dense
nutriments,
irregular
eating
frameworks,
disruptions
sleep
patterns
(inadequate
quality
duration),
engagement
shift
work,
known
jetlag.
rapid
evolution
life
domestic
routines
has
significantly
outpaced
rate
genetic
adaptation.
Consequently,
underlying
rhythms
exposed
multiple
shifts,
thereby
elevating
susceptibility
disease
predisposition.
comprehensive
review
endeavors
synthesize
existing
empirical
evidence
that
substantiates
conceptual
integration
clock,
biochemical
molecular
homeostasis,
oxidative
stress,
stimuli
imparted
exercise,
sleep,
nutrition.
New England Journal of Medicine,
Journal Year:
2021,
Volume and Issue:
384(6), P. 550 - 561
Published: Feb. 10, 2021
Molecular
insights
into
diurnal
variations
in
human
physiology
and
behavior
are
extending
our
understanding
of
a
wide
range
disease
processes.
Chronobiology
is
also
providing
testable
hypotheses
regarding
the
timing
treatments.
Communications Biology,
Journal Year:
2021,
Volume and Issue:
4(1)
Published: Nov. 18, 2021
Modern
societies
are
experiencing
an
increasing
trend
of
reduced
sleep
duration,
with
nocturnal
sleeping
time
below
the
recommended
ranges
for
health.
Epidemiological
and
laboratory
studies
have
demonstrated
detrimental
effects
deprivation
on
Sleep
exerts
immune-supportive
function,
promoting
host
defense
against
infection
inflammatory
insults.
has
been
associated
alterations
innate
adaptive
immune
parameters,
leading
to
a
chronic
state
increased
risk
infectious/inflammatory
pathologies,
including
cardiometabolic,
neoplastic,
autoimmune
neurodegenerative
diseases.
Here,
we
review
recent
advancements
responses
as
evidenced
by
experimental
epidemiological
studies,
pathophysiology,
role
deprivation-induced
changes
in
Gaps
knowledge
methodological
pitfalls
still
remain.
Further
understanding
causal
relationship
between
deregulation
would
help
identify
individuals
at
disease
prevent
adverse
health
outcomes.
Science,
Journal Year:
2020,
Volume and Issue:
371(6524)
Published: Dec. 31, 2020
Doubts
in
cancer-rhythms
connections
Circadian
clocks
help
to
coordinate
physiological
processes
with
the
daily
cycles
of
light
and
dark
periods
feeding,
activity,
rest.
Being
out
sync
such
24-hour
can
have
unhealthy
effects.
Sancar
Van
Gelder
review
available
evidence
regarding
circadian
disruption
predisposition
cancer
variations
response
chemotherapy.
The
literature
be
difficult
interpret.
For
example,
complete
knockouts
clock
genes
are
not
same
as
shift
work.
Overall,
they
find
that
jury
is
still
on
whether
promote
general
if
timing
treatment
optimized.
However,
enough
indications
present
further
research
recommended.
Science
,
this
issue
p.
42
Journal of The Royal Society Interface,
Journal Year:
2022,
Volume and Issue:
19(193)
Published: Aug. 1, 2022
Hundreds
of
studies
have
found
that
weak
magnetic
fields
can
significantly
influence
various
biological
systems.
However,
the
underlying
mechanisms
behind
these
phenomena
remain
elusive.
Remarkably,
energies
implicated
in
effects
are
much
smaller
than
thermal
energies.
Here,
we
review
observations,
and
suggest
an
explanation
based
on
radical
pair
mechanism,
which
involves
quantum
dynamics
electron
nuclear
spins
transient
molecules.
While
mechanism
has
been
studied
detail
context
avian
magnetoreception,
reviewed
here
show
magnetosensitivity
is
widespread
throughout
biology.
We
field
physiological
functions,
discussing
static,
hypomagnetic
oscillating
fields,
as
well
isotope
effects.
then
a
potential
unifying
model
for
described
effects,
discuss
plausible
candidate
molecules
pairs.
recent
proposing
provides
explanations
xenon
anaesthesia
lithium
treatment
hyperactivity,
circadian
clock,
neurogenesis
microtubule
assembly.
conclude
by
future
lines
investigation
this
exciting
new
area
