Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health DOI Creative Commons
Cristina Manuela Drăgoi, Alina Nicolae, Anca Ungurianu

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 138 - 138

Published: Jan. 11, 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.

Language: Английский

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents DOI
Helmut Sies, Dean P. Jones

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(7), P. 363 - 383

Published: March 30, 2020

Language: Английский

Citations

3670

Circadian Mechanisms in Medicine DOI
Ravi Allada, Joseph Bass

New England Journal of Medicine, Journal Year: 2021, Volume and Issue: 384(6), P. 550 - 561

Published: Feb. 10, 2021

Molecular insights into diurnal variations in human physiology and behavior are extending our understanding of a wide range disease processes. Chronobiology is also providing testable hypotheses regarding the timing treatments.

Language: Английский

Citations

384

Role of sleep deprivation in immune-related disease risk and outcomes DOI Creative Commons
Sergio Garbarino, Paola Lanteri, Nicola Luigi Bragazzi

et al.

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: Nov. 18, 2021

Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health. Epidemiological and laboratory studies have demonstrated detrimental effects deprivation on Sleep exerts immune-supportive function, promoting host defense against infection inflammatory insults. has been associated alterations innate adaptive immune parameters, leading to a chronic state increased risk infectious/inflammatory pathologies, including cardiometabolic, neoplastic, autoimmune neurodegenerative diseases. Here, we review recent advancements responses as evidenced by experimental epidemiological studies, pathophysiology, role deprivation-induced changes in Gaps knowledge methodological pitfalls still remain. Further understanding causal relationship between deregulation would help identify individuals at disease prevent adverse health outcomes.

Language: Английский

Citations

340

Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

213

Clocks, cancer, and chronochemotherapy DOI
Aziz Sancar, Russell N. Van Gelder

Science, Journal Year: 2020, Volume and Issue: 371(6524)

Published: Dec. 31, 2020

Doubts in cancer-rhythms connections Circadian clocks help to coordinate physiological processes with the daily cycles of light and dark periods feeding, activity, rest. Being out sync such 24-hour can have unhealthy effects. Sancar Van Gelder review available evidence regarding circadian disruption predisposition cancer variations response chemotherapy. The literature be difficult interpret. For example, complete knockouts clock genes are not same as shift work. Overall, they find that jury is still on whether promote general if timing treatment optimized. However, enough indications present further research recommended. Science , this issue p. 42

Language: Английский

Citations

211

Circadian rhythms in neurodegenerative disorders DOI
Malik Nassan, Aleksandar Videnović

Nature Reviews Neurology, Journal Year: 2021, Volume and Issue: 18(1), P. 7 - 24

Published: Nov. 10, 2021

Language: Английский

Citations

167

The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock DOI Creative Commons
John F. Brooks,

Cassie L. Behrendt,

Kelly A. Ruhn

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(16), P. 4154 - 4167.e12

Published: July 28, 2021

Language: Английский

Citations

165

A photoregulatory mechanism of the circadian clock in Arabidopsis DOI
Xu Wang, Bochen Jiang, Lianfeng Gu

et al.

Nature Plants, Journal Year: 2021, Volume and Issue: 7(10), P. 1397 - 1408

Published: Oct. 14, 2021

Language: Английский

Citations

134

Magnetic field effects in biology from the perspective of the radical pair mechanism DOI Creative Commons
Hadi Zadeh‐Haghighi, Christoph Simon

Journal of The Royal Society Interface, Journal Year: 2022, Volume and Issue: 19(193)

Published: Aug. 1, 2022

Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, energies implicated in effects are much smaller than thermal energies. Here, we review observations, and suggest an explanation based on radical pair mechanism, which involves quantum dynamics electron nuclear spins transient molecules. While mechanism has been studied detail context avian magnetoreception, reviewed here show magnetosensitivity is widespread throughout biology. We field physiological functions, discussing static, hypomagnetic oscillating fields, as well isotope effects. then a potential unifying model for described effects, discuss plausible candidate molecules pairs. recent proposing provides explanations xenon anaesthesia lithium treatment hyperactivity, circadian clock, neurogenesis microtubule assembly. conclude by future lines investigation this exciting new area

Language: Английский

Citations

129

Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions DOI Open Access

Vivaswath S. Ayyar,

Siddharth Sukumaran

Journal of Pharmacokinetics and Pharmacodynamics, Journal Year: 2021, Volume and Issue: 48(3), P. 321 - 338

Published: April 1, 2021

Language: Английский

Citations

126