Rhythms in Remodeling: Posttranslational Regulation of Bone by the Circadian Clock DOI Creative Commons
Gongsheng Yuan

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 705 - 705

Published: March 13, 2025

The circadian clock is a fundamental timekeeping system that regulates rhythmic biological processes in response to environmental light–dark cycles. In mammals, core genes (CLOCK, BMAL1, PER, and CRY) orchestrate these rhythms through transcriptional–translational feedback loops, influencing various physiological functions, including bone remodeling. Bone homeostasis relies on the coordinated activities of osteoblasts, osteoclasts, osteocytes, with increasing evidence highlighting role regulation maintaining skeletal integrity. Disruptions are linked disorders such as osteoporosis. Posttranslational modifications (PTMs), phosphorylation, acetylation, ubiquitination, serve crucial regulators both mechanisms metabolism. However, specific PTMs integrating timing remodeling remains underexplored. This review examines intersection biology, elucidating their impact cell function homeostasis. Understanding interactions may uncover novel therapeutic targets for diseases associated disruptions.

Language: Английский

Brain-muscle communication prevents muscle aging by maintaining daily physiology DOI
Arun Kumar, Mireia Vaca-Dempere, Thomas Mortimer

et al.

Science, Journal Year: 2024, Volume and Issue: 384(6695), P. 563 - 572

Published: May 2, 2024

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions importance of intratissue networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic module involving central peripheral (muscle) clock. Reconstituting brain-muscle sufficient to preserve fundamental homeostatic functions prevent aging. However, achieving whole requires contributions from other clocks. Mechanistically, acts as gatekeeper, selectively suppressing detrimental signals while integrating important functions. Our research reveals interplay between clocks function underscores impact eating patterns on these interactions.

Language: Английский

Citations

20
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation DOI
Mohammad Souri, Sohail Elahi, M. Soltani

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(3), P. 495 - 511

Published: Feb. 24, 2024

Breast cancer is a global health concern that demands attention. In our contribution to addressing this disease, study focuses on investigating wireless micro-device for intratumoral drug delivery, utilizing electrochemical actuation. Microdevices have emerged as promising approach in field due their ability enable controlled injections various applications.

Language: Английский

Citations

18
Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health DOI Creative Commons
Cristina Manuela Drăgoi, Alina Nicolae, Anca Ungurianu

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 138 - 138

Published: Jan. 11, 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.

Language: Английский

Citations

16
The clinical impact of chronopharmacology on current medicine DOI Creative Commons
Mert Kaşkal, Mustafa Sevım,

Gökay Ülker

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract One of the goals clinical pharmacology is to optimize patient treatment by adopting new strategies which will increase efficacy and decrease adverse effects drugs. In literature, it has shown that effectiveness toxicity medications can vary significantly based on when they are administered, making timing a crucial factor in plans. Chronopharmacology relatively branch focuses adjusting drug administration times enhance outcomes. largely influenced an individual’s circadian rhythm refers periodic changes biological processes depending time day. The chronopharmacology influences practice, accumulating knowledge this field likely lead healthcare providers adopt for regimens. This review aims summarize impact particularly current practices highlight latest findings related chronophysiological mechanisms.

Language: Английский

Citations

2
What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research DOI Open Access

Hanna M. Butler-Struben,

Amanda C. Kentner, Brian C. Trainor

et al.

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 47(7), P. 1285 - 1291

Published: March 25, 2022

Language: Английский

Citations

49
Chronotherapy in Glioblastoma: state of the art and future perspectives DOI Creative Commons
Marina Petković, Melad Henis,

Oliver Heese

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 89, P. 104470 - 104470

Published: Feb. 15, 2023

Language: Английский

Citations

27
Chrono-tailored drug delivery systems: recent advances and future directions DOI Creative Commons

Christine T. Butler,

Aoife M. Rodgers, Annie M. Curtis

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(7), P. 1756 - 1775

Published: Feb. 28, 2024

Abstract Circadian rhythms influence a range of biological processes within the body, with central clock or suprachiasmatic nucleus (SCN) in brain synchronising peripheral clocks around body. These are regulated by external cues, most influential being light/dark cycle, order to synchronise day. Chrono-tailored circadian drug delivery systems (DDS) aim optimise releasing drugs at specific times day align Although this approach is still relatively new, it has potential enhance efficacy, minimise side effects, and improve patient compliance. DDS have been explored implemented various conditions, including asthma, hypertension, cancer. This review aims introduce biology provide an overview current research on chrono-tailored DDS, particular focus immunological applications vaccination. Finally, we draw some key challenges which need be overcome for before they can translated more widespread use clinical practice. Graphical

Language: Английский

Citations

11
Time of day as a critical variable in biology DOI Creative Commons
Randy J. Nelson, Jacob R. Bumgarner, Jennifer A. Liu

et al.

BMC Biology, Journal Year: 2022, Volume and Issue: 20(1)

Published: June 15, 2022

Abstract Background Circadian rhythms are important for all aspects of biology; virtually every aspect biological function varies according to time day. Although this is well known, variation across the day also often ignored in design and reporting research. For review, we analyzed top 50 cited papers 10 major domains sciences calendar year 2015. We repeated analysis 2019, hypothesizing that awarding a Nobel Prize 2017 achievements field circadian biology would highlight importance scientists many disciplines, improve time-of-day reporting. Results Our analyses these 1000 empirical papers, however, revealed most failed include sufficient temporal details when describing experimental methods few systematic differences existed between 2015 2019. Overall, only 6.1% reports included information about measures manipulations permit replication. Conclusions defining feature systems, knowing systems evaluated fundamentally information. Failing account hampers reproducibility laboratories, complicates interpretation results, reduces value data based predominantly on nocturnal animals extrapolating diurnal humans.

Language: Английский

Citations

32
TimeTeller for timing health: The potential of circadian medicine to improve performance, prevent disease and optimize treatment DOI Creative Commons

Benjamin Dose,

Müge Yalçin,

Sebastian P. M. Dries

et al.

Frontiers in Digital Health, Journal Year: 2023, Volume and Issue: 5

Published: April 18, 2023

Circadian medicine, the study of effects time on health and disease has seen an uprising in recent years as a means to enhance performance, optimize treatment timing. Our endogenous generating system -the circadian clock- regulates behavioural, physiological cellular processes. Disruptions clock, via external factors like shift work or jet lag, internal perturbations such genetic alterations, are linked increased risk various diseases obesity, diabetes, cardiovascular cancer. By aligning individual's clock with optimal times for performing daily routines, physical mental also effectiveness certain therapies can be improved. Despite benefits lack non-invasive tools characterizing limits potential field. TimeTeller is molecular/digital tool characterization rhythms prediction including timing, unlock medicine implementing it settings. Given multiple known potentially yet unknown dependent individual rhythms, utility this emerging biomarker best exploited data driven, personalized use cases, using information across lifestyle, care, research

Language: Английский

Citations

21
Circadian Clocks, Redox Homeostasis, and Exercise: Time to Connect the Dots? DOI Creative Commons
Conor McClean, Gareth W. Davison

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 256 - 256

Published: Jan. 28, 2022

Compelling research has documented how the circadian system is essential for maintenance of several key biological processes including homeostasis, cardiovascular control, and glucose metabolism. Circadian clock disruptions, or losses rhythmicity, have been implicated in development diseases, premature ageing, are regarded as health risks. Redox reactions involving reactive oxygen nitrogen species (RONS) regulate physiological functions such cell signalling immune response. However, oxidative stress associated with pathological effects RONS, resulting a loss damaging modifications to important molecules DNA. Direct connections established between rhythms on basis that disruptions can affect redox biology, vice versa, bi-directional relationship. For instance, expression activity antioxidant enzymes (SOD, GPx, CAT) appear follow patterns. Consequently, ability unravel these interactions opened an exciting area biology. Exercise exerts numerous benefits and, potent environmental cue, capacity adjust disrupted systems. In fact, response given exercise stimulus may also exhibit variation. At same time, relationship exercise, scrutinised, whereby it clear exercise-induced RONS elicit both helpful potentially harmful dependent type, intensity, duration exercise. To date, appears emerging interface rhythmicity stress/redox metabolism not explored relation This review aims summarise evidence supporting conceptual link clock, stimuli. We believe carefully designed investigations this nexus required, which could be harnessed tackle theories concerned with, example, existence optimal time accrue benefits.

Language: Английский

Citations

27