Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1224 - 1224
Published: June 22, 2022
Cellular
senescence
is
an
irreversible
state
of
cell
cycle
arrest
occurring
in
response
to
stressful
stimuli,
such
as
telomere
attrition,
DNA
damage,
reactive
oxygen
species,
and
oncogenic
proteins.
Although
beneficial
protective
several
physiological
processes,
excessive
senescent
burden
has
been
involved
various
pathological
conditions
including
aging,
tissue
dysfunction
chronic
diseases.
Oxidative
stress
(OS)
can
drive
due
a
loss
balance
between
pro-oxidant
stimuli
antioxidant
defences.
Therefore,
the
identification
characterization
compounds
capable
preventing
or
counteracting
phenotype
major
interest.
However,
despite
considerable
number
studies,
comprehensive
overview
main
molecules
OS-induced
still
lacking.
Here,
besides
brief
description
molecular
mechanisms
implicated
OS-mediated
we
review
discuss
role
enzymes,
mitochondria-targeting
compounds,
vitamins,
carotenoids,
organosulfur
nitrogen
non-protein
molecules,
minerals,
flavonoids,
non-flavonoids
with
anti-aging
potential,
therefore
offering
insights
into
innovative
lifespan-extending
approaches.
Journal of Clinical Investigation,
Journal Year:
2022,
Volume and Issue:
132(15)
Published: July 31, 2022
Cellular
senescence
is
a
hallmark
of
aging
defined
by
stable
exit
from
the
cell
cycle
in
response
to
cellular
damage
and
stress.
Senescent
cells
(SnCs)
can
develop
characteristic
pathogenic
senescence-associated
secretory
phenotype
(SASP)
that
drives
secondary
disrupts
tissue
homeostasis,
resulting
loss
repair
regeneration.
The
use
transgenic
mouse
models
which
SnCs
be
genetically
ablated
has
established
key
role
for
driving
age-related
disease.
Importantly,
senotherapeutics
have
been
developed
pharmacologically
eliminate
SnCs,
termed
senolytics,
or
suppress
SASP
other
markers
senescence,
senomorphics.
Based
on
extensive
preclinical
studies
as
well
small
clinical
trials
demonstrating
benefits
senotherapeutics,
multiple
are
under
way.
This
Review
discusses
diseases,
strategies
target
approaches
discover
advances
senolytics.
Biomedicines,
Journal Year:
2021,
Volume and Issue:
9(5), P. 524 - 524
Published: May 7, 2021
Alzheimer's
disease
(AD)
is
a
neurodegenerative
associated
with
human
aging.
Ten
percent
of
individuals
over
65
years
have
AD
and
its
prevalence
continues
to
rise
increasing
age.
There
are
currently
no
effective
modifying
treatments
for
AD,
resulting
in
increasingly
large
socioeconomic
personal
costs.
Increasing
age
an
increase
low-grade
chronic
inflammation
(inflammaging)
that
may
contribute
the
process
AD.
Although
exact
mechanisms
remain
unclear,
aberrant
elevation
reactive
oxygen
nitrogen
species
(RONS)
levels
from
several
endogenous
exogenous
processes
brain
not
only
affect
cell
signaling,
but
also
trigger
cellular
senescence,
inflammation,
pyroptosis.
Moreover,
compromised
immune
privilege
allows
infiltration
peripheral
cells
infectious
agents
play
role.
Additionally,
meta-inflammation
as
well
gut
microbiota
dysbiosis
drive
neuroinflammatory
process.
Considering
inflammatory/immune
pathways
dysregulated
parallel
cognitive
dysfunction
elucidating
relationship
between
central
nervous
system
facilitate
development
safe
therapy
We
discuss
some
current
ideas
on
inflammaging
appear
summarize
details
few
immunomodulatory
strategies
being
developed
selectively
target
detrimental
aspects
neuroinflammation
without
affecting
defense
against
pathogens
tissue
damage.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 23
Published: Oct. 19, 2022
Reactive
oxygen
species
(ROS)
are
bioproducts
of
cellular
metabolism.
There
is
a
range
molecules
with
oxidizing
properties
known
as
ROS.
Despite
those
being
implied
negatively
in
aging
and
numerous
diseases,
their
key
role
signaling
evident.
ROS
control
several
biological
processes
such
inflammation,
proliferation,
cell
death.
The
redox
underlying
these
events
one
characteristic
the
new
generation
scientists
aimed
at
defining
environment.
potential,
which
includes
balance
sources
antioxidant
system,
implies
an
important
target
for
understanding
cells’
fate
derived
from
signaling.
In
this
review,
we
summarized
chemical,
balance,
signaling,
implications
aging.
