Journal of Statistical Mechanics Theory and Experiment,
Journal Year:
2022,
Volume and Issue:
2022(1), P. 013209 - 013209
Published: Jan. 1, 2022
We
consider
one-dimensional
systems
comprising
either
active
run-and-tumble
particles
(RTPs)
or
passive
Brownian
random
walkers.
These
are
noninteracting
have
hardcore
exclusions.
study
the
dynamics
of
a
single
tracer
particle
embedded
in
such
system
-
this
may
be
passive,
with
exclusion
from
environmental
particles.
In
an
environment,
both
and
tracers
show
long-time
subdiffusion:
displacements
scale
as
$t^{1/4}$
density-dependent
prefactor
that
is
independent
type,
differs
corresponding
result
for
passive-in-passive
subdiffusion.
environment
particles,
results
recovered
at
low
densities
tracers,
but
transient
caging
effects
slow
motion
higher
densities,
delaying
onset
any
regime.
For
we
find
more
complex
outcomes,
which
depend
on
details
dynamical
discretization
scheme.
interpret
these
by
studying
density
distribution
around
tracer.
particular,
sticking
to
cause
it
move
slowly
than
interacting
environments,
while
anomalous
behaviour
active-in-passive
cases
stems
`snowplough'
effect
whereby
large
pile
diffusive
accumulates
front
RTP
during
ballistic
run.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 29, 2024
Doublecortin
(DCX)
is
a
microtubule-associated
protein
critical
for
brain
development.
Although
most
highly
expressed
in
the
developing
central
nervous
system,
molecular
function
of
DCX
neuron
morphogenesis
remains
unknown
and
controversial.
We
demonstrate
that
intimately
linked
to
its
microtubule-binding
activity.
By
using
human
induced
pluripotent
stem
cell
(hiPSC)-
derived
cortical
i
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: May 2, 2024
Purpose
TUBB
can
encode
a
beta-tubulin
protein.
At
present,
the
role
of
has
not
been
ascertained
in
cancers.
Hence,
importance
further
systematic
pan-cancer
analyses
is
stressed
to
explore
its
value
diagnosis,
prognosis,
and
immune
function
Methods
By
collecting
handling
integrative
data
from
TCGA,
Firehose,
UCSC
Xena,
cBioPortal,
GEO,
CPTAC,
TIMER2.0,
TISCH,
CellMiner,
GDSC,
CTRP
databases,
we
explored
potential
diagnostic
prognostic
roles
pan-cancers
multiple
angles.
Moreover,
GSEA
analysis
was
conducted
excavate
biological
functions
pan-cancers.
In
addition,
survival
profiles
were
described,
differential
expressions
different
molecular
subtypes
discussed.
Also,
utilized
cMAP
search
drugs
or
micro-molecules
that
have
an
impact
on
expressions.
Results
Based
TCGA
data,
found
differentially
expressed
variety
tumors
showed
early-diagnostic
value.
Mutations,
somatic
copy
number
alterations,
DNA
methylation
would
lead
abnormal
expression.
had
relations
with
many
clinical
features.
What’s
more,
validated
be
related
metabolism-related,
metastasis-related,
immune-related
pathways.
High
proved
great
prognosis
various
types
cancers
affect
sensitivity
some
drugs.
We
also
demonstrated
expression
significantly
correlated
immunoregulator
molecules
biomarkers
lymphocyte
subpopulation
infiltration.
Conclusion
regulatory
genes
systemically
analyzed
this
study,
showing
satisfying
performances
disease
diagnosing
predicting
It
could
remodel
tumor
microenvironment
play
integral
guiding
cancer
therapies
forecasting
responses
chemotherapy.
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: July 5, 2022
Neurons
are
highly
polarized
cells
with
elaborate
shapes
that
allow
them
to
perform
their
function.
In
neurons,
microtubule
organization—length,
density,
and
dynamics—are
essential
for
the
establishment
of
polarity,
growth,
transport.
A
mounting
body
evidence
shows
modulation
cytoskeleton
by
microtubule-associated
proteins
fine
tunes
key
aspects
neuronal
cell
biology.
this
respect,
severing
enzymes—spastin,
katanin
fidgetin—a
group
bind
generate
internal
breaks
in
lattice,
emerging
as
modulators
different
model
systems.
review,
we
provide
an
integrative
view
on
latest
research
demonstrating
role
spastin
specifically
context
axonal
We
focus
function
regulation
organization,
transport,
underlie
its
importance
intricate
control
axon
branching
regeneration.
Journal of Statistical Mechanics Theory and Experiment,
Journal Year:
2022,
Volume and Issue:
2022(1), P. 013209 - 013209
Published: Jan. 1, 2022
We
consider
one-dimensional
systems
comprising
either
active
run-and-tumble
particles
(RTPs)
or
passive
Brownian
random
walkers.
These
are
noninteracting
have
hardcore
exclusions.
study
the
dynamics
of
a
single
tracer
particle
embedded
in
such
system
-
this
may
be
passive,
with
exclusion
from
environmental
particles.
In
an
environment,
both
and
tracers
show
long-time
subdiffusion:
displacements
scale
as
$t^{1/4}$
density-dependent
prefactor
that
is
independent
type,
differs
corresponding
result
for
passive-in-passive
subdiffusion.
environment
particles,
results
recovered
at
low
densities
tracers,
but
transient
caging
effects
slow
motion
higher
densities,
delaying
onset
any
regime.
For
we
find
more
complex
outcomes,
which
depend
on
details
dynamical
discretization
scheme.
interpret
these
by
studying
density
distribution
around
tracer.
particular,
sticking
to
cause
it
move
slowly
than
interacting
environments,
while
anomalous
behaviour
active-in-passive
cases
stems
`snowplough'
effect
whereby
large
pile
diffusive
accumulates
front
RTP
during
ballistic
run.
