Nature Cell Biology,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1571 - 1584
Published: Aug. 8, 2024
Abstract
Caloric
restriction
and
intermittent
fasting
prolong
the
lifespan
healthspan
of
model
organisms
improve
human
health.
The
natural
polyamine
spermidine
has
been
similarly
linked
to
autophagy
enhancement,
geroprotection
reduced
incidence
cardiovascular
neurodegenerative
diseases
across
species
borders.
Here,
we
asked
whether
cellular
physiological
consequences
caloric
depend
on
metabolism.
We
report
that
levels
increased
upon
distinct
regimens
or
in
yeast,
flies,
mice
volunteers.
Genetic
pharmacological
blockade
endogenous
synthesis
fasting-induced
nematodes
cells.
Furthermore,
perturbing
pathway
vivo
abrogated
lifespan-
healthspan-extending
effects,
as
well
cardioprotective
anti-arthritic
fasting.
Mechanistically,
mediated
these
effects
via
induction
hypusination
translation
regulator
eIF5A.
In
summary,
polyamine–hypusination
axis
emerges
a
phylogenetically
conserved
metabolic
control
hub
for
fasting-mediated
enhancement
longevity.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2022,
Volume and Issue:
18(1), P. 467 - 492
Published: Nov. 2, 2022
Reprogrammed
metabolism
is
a
hallmark
of
colorectal
cancer
(CRC).
CRC
cells
are
geared
toward
rapid
proliferation,
requiring
nutrients
and
the
removal
cellular
waste
in
nutrient-poor
environments.
Intestinal
stem
(ISCs),
primary
cell
origin
for
CRCs,
must
adapt
their
along
adenoma-carcinoma
sequence
to
unique
features
complex
microenvironment
that
include
interactions
with
intestinal
epithelial
cells,
immune
stromal
commensal
microbes,
dietary
components.
Emerging
evidence
implicates
modifiable
risk
factors
related
environment,
such
as
diet,
important
pathogenesis.
Here,
we
focus
on
describing
ISCs,
diets
influence
initiation,
genetics
metabolism,
tumor
microenvironment.
The
mechanistic
links
between
environmental
factors,
metabolic
adaptations,
enhancing
or
supporting
tumorigenesis
becoming
better
understood.
Thus,
greater
knowledge
holds
promise
improved
prevention
treatment.
Biochemical Pharmacology,
Journal Year:
2022,
Volume and Issue:
201, P. 115074 - 115074
Published: May 11, 2022
The
liver
controls
the
systemic
exposure
of
amino
acids
entering
via
gastro-intestinal
tract.
For
most
except
branched
chain
acids,
hepatic
uptake
is
very
efficient.
This
implies
that
orchestrates
acid
metabolism
and
also
exposure.
Although
many
transporters
have
been
identified,
cloned
investigated
with
respect
to
substrate
specificity,
transport
mechanism,
zonal
distribution,
which
these
players
are
involved
in
hepatocellular
remains
unclear.
Here,
we
aim
provide
a
review
current
insight
into
molecular
machinery
transport.
Furthermore,
place
this
information
comprehensive
overview
transport,
signalling
metabolism.
European Heart Journal,
Journal Year:
2023,
Volume and Issue:
44(36), P. 3423 - 3439
Published: July 14, 2023
Plant-based
diets
have
become
increasingly
popular
thanks
to
their
purported
health
benefits
and
more
recently
for
positive
environmental
impact.
Prospective
studies
suggest
that
consuming
vegetarian
is
associated
with
a
reduced
risk
of
developing
cardiovascular
disease
(CVD),
diabetes,
hypertension,
dementia,
cancer.
Data
from
randomized
clinical
trials
confirmed
protective
effect
the
prevention
diabetes
reductions
in
weight,
blood
pressure,
glycosylated
haemoglobin
low-density
lipoprotein
cholesterol,
but
date,
no
data
are
available
event
rates
cognitive
impairment,
there
very
limited
Moreover,
not
all
plant-based
foods
equally
healthy.
Unhealthy
poor
specific
nutrients
(vitamin
B12,
iron,
zinc,
calcium)
and/or
rich
highly
processed
refined
increase
morbidity
mortality.
Further
mechanistic
desirable
understand
whether
advantages
healthy,
minimally
represent
an
all-or-nothing
phenomenon
primarily
containing
small
quantities
animal
products
(e.g.
pesco-vegetarian
or
Mediterranean
diets)
has
beneficial,
detrimental,
neutral
effects
on
cardiometabolic
outcomes.
Further,
warranted
enhance
our
understanding
about
healthy
food
patterns
biological
mechanisms
linking
dietary
factors,
CVD,
other
metabolic
diseases.
Immunity & Ageing,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: June 8, 2023
Aging
is
a
gradual,
continuous
series
of
natural
changes
in
biological,
physiological,
immunological,
environmental,
psychological,
behavioral,
and
social
processes.
entails
the
immune
system
characterized
by
decrease
thymic
output
naïve
lymphocytes,
an
accumulated
chronic
antigenic
stress
notably
caused
infections
such
as
cytomegalovirus
(CMV),
cell
senescence
with
acquisition
inflammatory
senescence-associated
secretory
phenotype
(SASP).
For
this
reason,
due
to
SASP
originating
from
other
tissues,
aging
commonly
accompanied
low-grade
inflammation,
termed
"inflammaging".
After
decades
accumulating
evidence
regarding
age-related
processes
domain
now
appears
mature
enough
allow
integrative
reinterpretation
old
data.
Here,
we
provide
overview
topics
discussed
recent
workshop
"Aging
Chronic
Inflammation"
which
many
major
players
field
contributed.
We
highlight
advances
systematic
measurement
interpretation
biological
markers
aging,
well
their
implications
for
human
health
longevity
interventions
that
can
be
envisaged
maintain
or
improve
function
older
people.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 11, 2024
Abstract
Diet,
serving
as
a
vital
source
of
nutrients,
exerts
profound
influence
on
human
health
and
disease
progression.
Recently,
dietary
interventions
have
emerged
promising
adjunctive
treatment
strategies
not
only
for
cancer
but
also
neurodegenerative
diseases,
autoimmune
cardiovascular
metabolic
disorders.
These
demonstrated
substantial
potential
in
modulating
metabolism,
trajectory,
therapeutic
responses.
Metabolic
reprogramming
is
hallmark
malignant
progression,
deeper
understanding
this
phenomenon
tumors
its
effects
immune
regulation
significant
challenge
that
impedes
eradication.
Dietary
intake,
key
environmental
factor,
can
tumor
metabolism.
Emerging
evidence
indicates
might
affect
the
nutrient
availability
tumors,
thereby
increasing
efficacy
treatments.
However,
intricate
interplay
between
pathogenesis
other
diseases
complex.
Despite
encouraging
results,
mechanisms
underlying
diet-based
remain
largely
unexplored,
often
resulting
underutilization
management.
In
review,
we
aim
to
illuminate
various
interventions,
including
calorie
restriction,
fasting-mimicking
diet,
ketogenic
protein
restriction
high-salt
high-fat
high-fiber
aforementioned
diseases.
We
explore
multifaceted
impacts
these
encompassing
their
immunomodulatory
effects,
biological
impacts,
molecular
mechanisms.
This
review
offers
valuable
insights
into
application
therapies
Cell Metabolism,
Journal Year:
2023,
Volume and Issue:
35(1), P. 150 - 165.e4
Published: Jan. 1, 2023
Time-restricted
feeding
(TRF)
is
an
emerging
behavioral
nutrition
intervention
that
involves
a
daily
cycle
of
and
fasting.
In
both
animals
humans,
TRF
has
pleiotropic
health
benefits
arise
from
multiple
organ
systems,
yet
the
molecular
basis
TRF-mediated
not
well
understood.
Here,
we
subjected
mice
to
isocaloric
ad
libitum
(ALF)
or
western
diet
examined
gene
expression
changes
in
samples
taken
22
organs
brain
regions
collected
every
2
h
over
24-h
period.
We
discovered
profoundly
impacts
expression.
Nearly
80%
all
genes
show
differential
rhythmicity
under
at
least
one
tissue.
Functional
annotation
these
revealed
tissue-
pathway-specific
TRF.
These
findings
resources
provide
critical
foundation
for
future
mechanistic
studies
will
help
guide
human
time-restricted
eating
(TRE)
interventions
treat
various
disease
conditions
with
without
pharmacotherapies.
