Acute kidney injury

Nature Reviews Disease Primers, Journal Year: 2021, Volume and Issue: 7(1)

Published: July 15, 2021

Language: Английский

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Pathophysiology of COVID-19-associated acute kidney injury

Nature Reviews Nephrology, Journal Year: 2021, Volume and Issue: 17(11), P. 751 - 764

Published: July 5, 2021

Language: Английский

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The etiology of preeclampsia

American Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 226(2), P. S844 - S866

Published: Feb. 1, 2022

Language: Английский

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Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

Emerging Microbes & Infections, Journal Year: 2021, Volume and Issue: 10(1), P. 507 - 535

Published: Jan. 1, 2021

Without modern medical management and vaccines, the severity of Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) might approach magnitude 1894-plague (12 million deaths) 1918-A(H1N1) influenza (50 pandemics. The COVID-19 was heralded 2003 SARS epidemic which led to discovery human civet SARS-CoV-1, bat SARS-related-CoVs, Middle East (MERS)-related CoV HKU4 HKU5, other novel animal coronaviruses. suspected animal-to-human jumping 4 betacoronaviruses including coronaviruses OC43(1890), SARS-CoV-1(2003), MERS-CoV(2012), SARS-CoV-2(2019) indicates their significant potential. presence a large reservoir in bats wild mammals, culture mixing selling them urban markets with suboptimal hygiene, habit eating exotic mammals highly populated areas, rapid frequent air travels from these areas are perfect ingredients for brewing rapidly exploding epidemics. possibility emergence hypothetical SARS-CoV-3 or viruses animals laboratories, therefore needs global preparedness should not be ignored. We reviewed representative publications on epidemiology, virology, clinical manifestations, pathology, laboratory diagnostics, treatment, vaccination, infection control as 20 January 2021, is 1 year after person-to-person transmission SARS-CoV-2 announced. difficulties mass testing, labour-intensive contact tracing, importance compliance universal masking, low efficacy antiviral treatment disease, possibilities vaccine antiviral-resistant virus variants becoming another common cold discussed.

Language: Английский

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New Onset of Autoimmune Diseases Following COVID-19 Diagnosis

Cells, Journal Year: 2021, Volume and Issue: 10(12), P. 3592 - 3592

Published: Dec. 20, 2021

There is growing evidence that coronavirus disease 2019 (COVID-19) can lead to a dysregulation of the immune system with development autoimmune phenomena. The consequence this ranges from production autoantibodies onset rheumatic disease. In context, we conducted systematic review analyze current data regarding new-onset systemic and diseases in COVID-19 patients. A literature search PubMed Scopus databases December September 2021 identified 99 patients fulfilled specific diagnostic/classification criteria and/or nomenclature for each main reported were vasculitis arthritis. Idiopathic inflammatory myopathies, lupus erythematosus, sarcoidosis also limited number patients, as well isolated cases sclerosis adult-onset Still's These findings highlight potential spectrum could be precipitated by SARS-CoV-2 infection. Complementary studies are needed discern link between new onset-rheumatic so knowledge used early diagnosis most suitable management.

Language: Английский

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Preeclampsia and eclampsia: the conceptual evolution of a syndrome

American Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 226(2), P. S786 - S803

Published: Feb. 1, 2022

Language: Английский

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Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19

JAMA Network Open, Journal Year: 2021, Volume and Issue: 4(3), P. e211095 - e211095

Published: March 10, 2021

Importance

Acute kidney injury (AKI) occurs in up to half of patients hospitalized with coronavirus disease 2019 (COVID-19). The longitudinal effects COVID-19–associated AKI on function remain unknown.

Objective

To compare the rate change estimated glomerular filtration (eGFR) after hospital discharge between and without COVID-19 who experienced in-hospital AKI.

Design, Setting, Participants

A retrospective cohort study was conducted at 5 hospitals Connecticut Rhode Island from March 10 August 31, 2020. Patients were tested for developed screened, those survived past discharge, did not require dialysis within 3 days had least 1 outpatient creatinine level measurement following included.

Exposures

Diagnosis COVID-19.

Main Outcomes Measures

Mixed-effects models used assess association eGFR slope discharge. secondary outcome time recovery subgroup whose returned baseline by

Results

total 182 1430 associated population included 813 women (50.4%); median age 69.7 years (interquartile range, 58.9-78.9 years). more likely be Black (73 [40.1%] vs 225 [15.7%]) or Hispanic (40 [22%] 126 [8.8%]) fewer comorbidities than but similar rates preexisting chronic hypertension. a greater decrease unadjusted model (−11.3; 95% CI, –22.1 −0.4 mL/min/1.73 m²/y;P = .04) adjusting (−12.4; –23.7 −1.2 .03). In fully adjusted controlling comorbidities, peak level, requirement, difference persisted (−14.0; –25.1 −2.9 .01). achieved (n 319), decreased during follow-up (adjusted hazard ratio, 0.57; 0.35-0.92).

Conclusions Relevance

this US AKI, compared COVID-19, independent underlying severity. This trajectory may reinforce importance monitoring studying interventions limit

Language: Английский

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Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations

The Lancet Respiratory Medicine, Journal Year: 2023, Volume and Issue: 11(8), P. 739 - 754

Published: July 17, 2023

Individuals with SARS-CoV-2 infection can develop symptoms that persist well beyond the acute phase of COVID-19 or emerge after phase, lasting for weeks months initial illness. The post-acute sequelae COVID-19, which include physical, cognitive, and mental health impairments, are known collectively as long COVID post-COVID-19 condition. substantial burden this multisystem condition is felt at individual, health-care system, socioeconomic levels, on an unprecedented scale. Survivors COVID-19-related critical illness risk respiratory distress syndrome, sepsis, chronic illness, these multidimensional morbidities might be difficult to differentiate from specific effects COVID-19. We provide overview manifestations in adults. explore various organ systems, describe potential pathophysiological mechanisms, consider challenges providing clinical care support survivors manifestations. Research needed reduce incidence optimise therapeutic rehabilitative patients.

Language: Английский

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Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry

International Journal of Infectious Diseases, Journal Year: 2021, Volume and Issue: 107, P. 300 - 310

Published: Jan. 14, 2021

To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals.A cohort study laboratory-confirmed who were hospitalized from March 2020 September in 25 hospitals. Data collected medical records using Research Electronic Capture (REDCap) tools. A multivariate Poisson regression model was used assess risk factors for mortality.For a total 2,054 (52.6% male; median age 58 years), mortality 22.0%; this rose 47.6% those treated intensive care unit (ICU). Hypertension (52.9%), diabetes (29.2%), obesity (17.2%) most prevalent comorbidities. Overall, 32.5% required invasive mechanical ventilation, 12.1% kidney replacement therapy. Septic shock observed 15.0%, nosocomial infection 13.1%, thromboembolism 4.1%, acute heart failure 3.6%. Age >= 65 years, chronic disease, hypertension, C-reactive protein ≥ 100mg/dL, platelet count < 100×109/L, oxygen saturation 90%, need supplemental oxygen, ventilation at admission independently associated with higher mortality. The overall use antimicrobials 87.9%.This reveals characteristics confirmed Brazil. Certain easily assessed parameters hospital death. high frequency antibiotic points an over-use patients.

Language: Английский

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COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options

The Journal of Pathology, Journal Year: 2021, Volume and Issue: 254(4), P. 307 - 331

Published: Feb. 17, 2021

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread globally despite the worldwide implementation of preventive measures combat disease. Although most COVID-19 cases are characterised a mild, self-limiting course, considerable subset patients develop more condition, varying from pneumonia and distress (ARDS) multi-organ failure (MOF). Progression is thought occur as result complex interplay between multiple pathophysiological mechanisms, all which may orchestrate SARS-CoV-2 infection contribute organ-specific tissue damage. In this respect, dissecting currently available knowledge immunopathogenesis crucially important, not only improve our understanding its pathophysiology but also fuel rationale both novel repurposed treatment modalities. Various immune-mediated pathways during relevant in context, relate innate immunity, adaptive autoimmunity. Pathological findings specimens with provide valuable information regard well development evidence-based regimens. This review provides an updated overview main pathological changes observed within commonly affected organ systems, special emphasis on immunopathology. Current management strategies for include supportive care use or symptomatic drugs, such dexamethasone, remdesivir, anticoagulants. Ultimately, prevention key COVID-19, requires appropriate attenuate and, above all, effective vaccines. © 2021 The Authors. Journal Pathology published John Wiley & Sons, Ltd. behalf Society Great Britain Ireland.

Language: Английский

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