Regulated cell death pathways in kidney disease

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(5), P. 281 - 299

Published: March 23, 2023

Language: Английский

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Drug-induced oxidative stress in cancer treatments: Angel or devil?

Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102754 - 102754

Published: May 18, 2023

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one the most significant biological events cancer progression. Cancer cells generally represent a higher level, which suggests dual therapeutic strategy by regulating status (i.e., pro-oxidant therapy and/or antioxidant therapy). Indeed, exhibits great anti-cancer capability, attributing to accumulation within cells, whereas restore homeostasis has been claimed fail several clinical practices. Targeting vulnerability pro-oxidants capable generating excessive reactive oxygen species (ROS) surfaced an important strategy. However, multiple adverse effects caused indiscriminate attacks uncontrolled drug-induced OS on normal tissues and drug-tolerant capacity some certain greatly limit their further applications. Herein, we review representative oxidative drugs summarize side organs, emphasizing that seeking balance between damage value exploiting next-generation OS-based chemotherapeutics.

Language: Английский

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Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104357 - 104357

Published: March 12, 2023

Language: Английский

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Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity

JCI Insight, Journal Year: 2023, Volume and Issue: 8(8)

Published: March 14, 2023

Cisplatin is a widely used chemotherapy drug but it induces both acute and chronic kidney diseases (CKD) in cancer patients. The pathogenesis of cisplatin-induced CKD unclear effective renoprotective approaches are not available. Here, we report that repeated low-dose cisplatin (RLDC) treatment C57BL/6 mice induced cellular senescence tubules, accompanied with tubular degeneration pro-fibrotic phenotype transformation culminated maladaptive repair renal fibrosis. Suppression by senolytic drugs ABT-263 Fisetin attenuated fibrosis improved as indicated restoration regeneration function. In vitro, RLDC also mouse proximal BUMPT cells. eliminated senescent cells following treatment, reversed the increased their clonogenic activity. Moreover, alleviated paracrine effect RLDC-treated on fibroblasts for Consistently, knockdown p16 suppressed post-RLDC fibrotic changes cells, effects fibroblast proliferation. These results indicate persistent induction plays an important role promoting CKD. Targeting may be efficient to improve prevention

Language: Английский

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m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 15, 2023

Abstract Glycolytic reprogramming is one of the most important features cancer and plays an integral role in progression cancer. In cells, changes glucose metabolism meet needs self-proliferation, angiogenesis lymphangiogenesis, metastasis, also affect immune escape, prognosis evaluation therapeutic effect The n6-methyladenosine (m6A) modification RNA widespread eukaryotic cells. Dynamic reversible m6A modifications are widely involved regulation stem cell renewal differentiation, tumor therapy resistance, microenvironment, metabolism. Lately, more evidences show that can glycolysis process tumors a variety ways to regulate biological behavior tumors. this review, we discussed genesis development, elaborated detail profound impact on different by regulating glycolysis. We believe modified has great significance potential for treatment.

Language: Английский

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Discovering a New Drug Against Acute Kidney Injury by Using a Tailored Photoacoustic Imaging Probe

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 15, 2024

Abstract Acute kidney injury (AKI) has become an increasing concern for patients due to the widespread clinical use of nephrotoxic drugs. Currently, early diagnosis AKI is still challenging and available therapeutic drugs cannot meet demand. Herein, this work investigated key redox couple involved in develops a tailored photoacoustic (PA) imaging probe (AB‐DiOH) which can reversibly respond hypochlorite (ClO−)/glutathione (GSH) with high specificity sensitivity. This enables real‐time monitoring by noninvasive PA imaging, better detection sensitivity than blood test. Furthermore, utilized screening nephroprotective among natural products. For first time, astragalin discovered be potential new drug treatment AKI. After oral administration, efficiently absorbed animal body, alleviate injury, meanwhile induce no damage other normal tissues. The mechanism also been revealed simultaneous inhibition oxidative stress, ferroptosis, cuproposis. developed candidate provide promising tool strategy effective

Language: Английский

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Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 59 - 76

Published: Jan. 8, 2025

Language: Английский

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Therapeutic role of hucMSC-sEV-enriched miR-13896 in cisplatin-induced acute kidney injury through M2 macrophage polarization

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: Feb. 24, 2025

Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hucMSC-sEV) have recently garnered attention as a potential therapeutic approach for kidney diseases with anti-inflammatory effects. Infiltrated macrophages play an important role in facilitating tissue regeneration. However, the intricate regulatory effects of hucMSC-sEV on during cisplatin-induced acute injury (AKI) remain unknown. In this study, we uncovered that exhibited potent anti-inflammation and effectively inhibited polarization M1 phenotype macrophages. Mechanically, miRNA sequencing analysis qRT-PCR indicated novel miRNA, named miR-13896, was enriched hucMSC-sEV. When transfected miR-13896 mimic, displayed M2 elevated levels Arg1 IL-10, while inhibitor promoted phenotype. Furthermore, firstly established repressed Tradd expression by targeting its 3' untranslated region subsequently NF-κB signaling pathway Additionally, to improve effects, were engineered through electroporation, which resulted promoting macrophages, inhibiting inflammatory factors, enhancing repair. Conclusively, our findings provide insights into mechanisms underlying AKI, also highlighting electroporation promising strategy treating AKI.

Language: Английский

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Downregulation of LncRNA CCAT1 Enhances Chemosensitivity in Cisplatin‐Resistant Gastric Cancer Cells

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Jan. 20, 2025

ABSTRACT Chemotherapy is an effective treatment for gastric cancer. However, many patients develop resistance to chemotherapeutic agents during clinical treatment. LncRNA CCAT1 has recently been shown influence cellular specific drugs, but its role in cancer remains underexplored. This study aims investigate the of cisplatin cells and potential underlying mechanisms. Gastric cell lines with acquired were established. The expression was assessed both cisplatin‐sensitive cisplatin‐resistant AGS lines. knocked down AGS/DDP cells, changes IC50 values measured using Cell Counting Kit‐8 (CCK‐8) assay. Apoptosis evaluated by flow cytometry. Additionally, Western blotting employed measure levels PI3K/AKT/mTOR signaling pathway proteins apoptosis‐related interference control groups. RT‐qPCR results indicated that significantly elevated compared non‐resistant cells. Similarly, CCK‐8 assay demonstrated knocking resistant increased their sensitivity Flow cytometry blot further confirmed silencing promoted apoptosis these higher sensitive counterparts, resulted reduced proteins. In conclusion, above studies induced

Language: Английский

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The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure

Theranostics, Journal Year: 2023, Volume and Issue: 13(9), P. 2757 - 2773

Published: Jan. 1, 2023

Rationale: Cisplatin, a potent chemotherapeutic drug, induces side effects in normal tissues including the kidney.To reduce effects, repeated low-dose cisplatin (RLDC) is commonly used clinical setting.While RLDC reduces acute nephrotoxicity to certain extents, significant portion of patients later develop chronic kidney problems, underscoring need for novel therapeutics alleviate long-term sequelae therapy.Methods: In vivo, role HMGB1 was examined by testing neutralizing antibodies mice.In vitro, knockdown on RLDC-induced nuclear factor-κB (NF-κB) activation and fibrotic phenotype changes were tested proximal tubular cells.To study signal transducer activator transcription 1 (STAT1), siRNA its pharmacological inhibitor Fludarabine used.We also searched Gene Expression Omnibus (GEO) database transcriptional expression profiles evaluated biopsy samples from CKD verify STAT1/HMGB1/NF-κB signaling axis.Results: We found that induced tubule damage, interstitial inflammation, fibrosis mice, accompanied up-regulation HMGB1.Blockage HMGB1with Glycyrrhizin suppressed NF-κB associated production pro-inflammatory cytokines, reduced injury renal fibrosis, improved function after treatment.Consistently, decreased prevented RLDC-treated cells.At upstream, STAT1 cytoplasmic accumulation cells, suggesting critical activation.Upregulation along with inflammatory cytokines verified patients.Conclusion: These results unravel pathway contributes persistent inflammation problems nephrotoxicity, new therapeutic targets protection cancer receiving chemotherapy.

Language: Английский

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