Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine DOI Creative Commons
Giordani Rodrigues dos Passos, Tarso Adoni, María Fernanda Mendes

et al.

Arquivos de Neuro-Psiquiatria, Journal Year: 2023, Volume and Issue: 81(12), P. 1125 - 1133

Published: Dec. 1, 2023

Abstract Precision medicine has revolutionized the field of neuroimmunology, with innovative approaches that characterize diseases based on their biology, deeper understanding factors leading to heterogeneity within same disease, development targeted therapies, and strategies tailor therapies each patient. This review explores impact precision various neuroimmunological conditions, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), optic neuritis, autoimmune encephalitis, immune-mediated neuropathies. We discuss advances in subtyping, recognition novel entities, promising biomarkers, more selective monoclonal antibodies cutting-edge synthetic cell-based immunotherapies disorders. In addition, we analyze challenges related affordability equity implementation these emerging technologies, especially situations limited resources.

Language: Английский

Integrating TSPO-PET imaging with metabolomics for enhanced prognostic accuracy in multiple sclerosis DOI Creative Commons
Daniel E. Radford‐Smith, Abi G. Yates, Tereza Kačerová

et al.

BMJ Neurology Open, Journal Year: 2025, Volume and Issue: 7(1), P. e001026 - e001026

Published: Jan. 1, 2025

Background Predicting disease progression in multiple sclerosis (MS) remains challenging. PET imaging with 18 kDa translocator protein (TSPO) radioligands can detect microglial and astrocyte activation beyond MRI-visible lesions, which has been shown to be highly predictive of progression. We previously demonstrated that nuclear magnetic resonance (NMR)-based metabolomics could accurately distinguish between relapsing-remitting (RRMS) secondary progressive MS (SPMS). This study investigates whether combining TSPO enhances accuracy a similar setting. Methods Blood samples were collected from 87 patients undergoing the TSPO-binding radioligand 11 C-PK11195 Finland. Patient disability was assessed using expanded status scale (EDSS) at baseline 1 year later. Serum performed identify biomarkers associated binding Results Greater availability normal-appearing white matter perilesional regions correlated higher EDSS. metabolites glutamate (p=0.02), glutamine (p=0.006), glucose (p=0.008), detected by NMR, effectively distinguished future progressors. These three alone predicted same as TSPO-PET (AUC 0.78; p=0.0001), validated an independent cohort. Combining serum metabolite data significantly improved power, achieving AUC 0.98 (p<0.0001). Conclusion Measuring specific is effective predicting However, integrating analysis substantially accuracy. Given simplicity affordability NMR analysis, this approach lead more personalised, accessible treatment strategies serve valuable tool for clinical trial stratification.

Language: Английский

Citations

0
PET imaging of reactive astrocytes in neurological disorders DOI Creative Commons
Yi Liu, Han Jiang,

Xiyi Qin

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2021, Volume and Issue: 49(4), P. 1275 - 1287

Published: Dec. 7, 2021

Abstract The reactive astrocytes manifest molecular, structural, and functional remodeling in injury, infection, or diseases of the CNS, which play a critical role pathological mechanism neurological diseases. A growing need exists for dependable approach to better characterize activation astrocyte vivo. As an advanced molecular imaging technology, positron emission tomography (PET) has potential visualizing biological activities at cellular levels. In review, we summarized PET visualization strategies discussed applications Future studies are needed pay more attention development specific agents further improve our exploration various

Language: Английский

Citations

22
Super resolution imaging reconstruction reveals that gold standard methods may not correctly conclude neural/brain functional recovery DOI
Wei-Feng Huang, Hua Chen, Yan Guo

et al.

Computerized Medical Imaging and Graphics, Journal Year: 2023, Volume and Issue: 105, P. 102198 - 102198

Published: Feb. 14, 2023

Language: Английский

Citations

8
Luminescent Metal Complexes for Bioassays in the Near-Infrared (NIR) Region DOI
Guoqing Jin, Lijun Guo, Jing Zhang

et al.

Topics in Current Chemistry, Journal Year: 2022, Volume and Issue: 380(5)

Published: June 18, 2022

Language: Английский

Citations

13
Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine DOI Creative Commons
Giordani Rodrigues dos Passos, Tarso Adoni, María Fernanda Mendes

et al.

Arquivos de Neuro-Psiquiatria, Journal Year: 2023, Volume and Issue: 81(12), P. 1125 - 1133

Published: Dec. 1, 2023

Abstract Precision medicine has revolutionized the field of neuroimmunology, with innovative approaches that characterize diseases based on their biology, deeper understanding factors leading to heterogeneity within same disease, development targeted therapies, and strategies tailor therapies each patient. This review explores impact precision various neuroimmunological conditions, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), optic neuritis, autoimmune encephalitis, immune-mediated neuropathies. We discuss advances in subtyping, recognition novel entities, promising biomarkers, more selective monoclonal antibodies cutting-edge synthetic cell-based immunotherapies disorders. In addition, we analyze challenges related affordability equity implementation these emerging technologies, especially situations limited resources.

Language: Английский

Citations

7