Inhibitory and disinhibitory VIP IN-mediated circuits in neocortex DOI Creative Commons

Shlomo S. Dellal,

Hector Zurita, Manuel Valero

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Cortical GABAergic interneurons (INs) are comprised of distinct types that provide tailored inhibition to pyramidal cells (PCs) and other INs, thereby enabling precise control cortical circuit activity. INs expressing the neuropeptide vasoactive-intestinal peptide (VIP) have attracted attention recently following discovery they predominantly function by inhibiting dendritic-targeting somatostatin (SST) disinhibiting PCs. This VIP-SST disinhibitory motif is observed throughout neocortex from mice humans, serves as a key mechanism for top-down (feedback) context-dependent information processing. Thus, VIP IN-mediated disinhibition has been found play an important role in sensory processing, executive functions, attention, sensorimotor integration cortico-cortical thalamocortical feedback interactions. Furthermore, implicated mediating effects reinforcement signals, both reward aversive, via their responsiveness neuromodulators such acetylcholine (ACh), facilitating synaptic plasticity learning. While it evident transcriptomic analyses molecularly heterogeneous group, physiological significance this diversity unclear at present. Here, we characterized functional primary somatosensory cortex leveraging intersectional genetic approaches study IN subtypes. We can be divided into four different populations: group expresses Ca 2+ -binding protein calretinin (CR), two groups express cholecystokinin (CCK), does not either CR or CCK (non-CCK non-CR; nCCK nCR). neurons each exhibit laminar distributions, axonal dendritic arbors, intrinsic electrophysiological properties, efferent connectivity, VIP/CR target almost exclusively SST VIP/nCCK nCR also mainly but connections parvalbumin (PV) INs. These essentially no connectivity (PCs). On hand, VIP/CCK PCs, differ degree which release type modulated endocannabinoids. long-range inputs differentially recruit groups. Intriguingly, find populations subtypes turn, indicating presence specialized subcircuits. Activation subpopulations vivo results differential on network, thus providing evidence modularity actions during

Language: Английский

Hippocampal GABAergic interneurons and memory DOI Creative Commons
Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(20), P. 3154 - 3175

Published: July 18, 2023

One of the most captivating questions in neuroscience revolves around brain's ability to efficiently and durably capture store information. It must process continuous input from sensory organs while also encoding memories that can persist throughout a lifetime. What are cellular-, subcellular-, network-level mechanisms underlie this remarkable capacity for long-term information storage? Furthermore, what contributions do distinct types GABAergic interneurons make process? As hippocampus plays pivotal role memory, our review focuses on three aspects: (1) delineation hippocampal interneuron their connectivity, (2) plasticity, (3) activity patterns during memory-related rhythms, including long-range disinhibition. We explore how these elements, together showcasing diversity inhibitory circuits, shape processing hippocampus.

Language: Английский

Citations

58
Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells DOI

Elizabeth P. Lackey,

Luis Moreira,

Aliya Norton

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2333 - 2348.e6

Published: April 30, 2024

Language: Английский

Citations

19
Neocortical somatostatin neuron diversity in cognition and learning DOI Creative Commons
Eunsol Park, Matthew B. Mosso, Alison L. Barth

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
The plasticitome of cortical interneurons DOI

Amanda R. McFarlan,

Christina Y. C. Chou, Airi Watanabe

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 24(2), P. 80 - 97

Published: Dec. 30, 2022

Language: Английский

Citations

47
Nucleus reuniens transiently synchronizes memory networks at beta frequencies DOI Creative Commons
Maanasa Jayachandran, Tatiana D. Viena, Andy Garcia

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 19, 2023

Abstract Episodic memory-based decision-making requires top-down medial prefrontal cortex and hippocampal interactions. This integrated prefrontal-hippocampal memory state is thought to be organized by synchronized network oscillations mediated connectivity with the thalamic nucleus reuniens (RE). Whether how RE synchronizes networks in memory, however, remains unknown. Here, we recorded local field potentials from prefrontal-RE-hippocampal while rats engaged a nonspatial sequence task, thereby isolating memory-related activity running-related oscillations. We found that synchronous beta bursts (15–30 Hz) dominated during trials, whereas theta (6–12 non-memory–related running. Moreover, appeared first, followed beta, suggesting could driven RE. To test whether capable of driving synchrony, used an optogenetic approach (retroAAV-ChR2). activation induced coherence reduced coherence, matching observed memory-driven task. These findings are first demonstrate contributes transient system, facilitating interactions underlie decision-making.

Language: Английский

Citations

40
Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks DOI

Bert Vancura,

Tristan Geiller, Andres Grosmark

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(5), P. 788 - 797

Published: April 20, 2023

Language: Английский

Citations

31
Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer’s disease DOI Creative Commons
Orly Lazarov, Muskan Gupta, Pavan Kumar

et al.

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 236, P. 102601 - 102601

Published: April 1, 2024

Here, we provide an in-depth consideration of our current understanding engrams, spanning from molecular to network levels, and hippocampal neurogenesis, in health Alzheimer's disease (AD). This review highlights novel findings these emerging research fields future directions for therapeutic avenues memory failure dementia. Engrams, AD, neurogenesis have each been extensively studied. The integration topics, however, has relatively less deliberated, is the focus this review. We primarily on dentate gyrus (DG) hippocampus, which a key area episodic formation. Episodic significantly impaired also site adult neurogenesis. Advancements technology, especially opto- chemogenetics, made sophisticated manipulations engram cells possible. Furthermore, innovative methods emerged monitoring neurons, even specific neuronal populations, vivo while animals engage tasks, such as calcium imaging. In imaging contributes more comprehensive cells. Critically, studies DG using technologies shown important contribution both AD. Together, discussion topics provides holistic perspective that motivates questions research.

Language: Английский

Citations

12
Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory DOI Creative Commons
Suhel Tamboli, Sanjay Singh,

Dimitry Topolnik

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(4), P. 114115 - 114115

Published: April 1, 2024

In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, specific behavioral conditions that lead to disinhibition remain uncertain. To investigate relevance of VIP-IN activity, we employed wireless technologies allowing us monitor and manipulate their function freely behaving mice. Our findings reveal that, during spatial exploration new environments, VIP-INs hippocampal region become highly active, facilitating rapid encoding novel information. Remarkably, both pyramidal neurons (PNs) exhibit increased activity when encountering changes environment, including context- object-related alterations. Concurrently, somatostatin- parvalbumin-expressing inhibitory populations show an inverse relationship with PN revealing occurs on timescale seconds. Thus, VIP-IN-mediated may constitute crucial element novelty acquisition recognition memory.

Language: Английский

Citations

11
Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice DOI Creative Commons
Thomas Hainmueller, Aurore Cazala, Li-Wen Huang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 24, 2024

Abstract The hippocampus is the brain’s center for episodic memories. Its subregions, dentate gyrus and CA1-3, are differentially involved in memory encoding recall. Hippocampal principal cells represent features like movement, space, context, but less known about GABAergic interneurons. Here, we performed two-photon calcium imaging of parvalbumin- somatostatin-expressing interneurons CA1-3 male mice exploring virtual environments. Parvalbumin-interneurons increased activity with running-speed reduced it novel Somatostatin-interneurons behaved similar to parvalbumin-expressing cells, their counterparts during rest Congruently, chemogenetic silencing parvalbumin-interneurons had prominent effects familiar contexts, while similarity granule cell representations between Our data indicate unique roles somatostatin-positive that distinct from those may support routing information.

Language: Английский

Citations

9
Gamma oscillation plasticity is mediated via parvalbumin interneurons DOI Creative Commons
Michael D. Hadler, Alexandra Tzilivaki, Dietmar Schmitz

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(5)

Published: Jan. 31, 2024

Understanding the plasticity of neuronal networks is an emerging field (patho-) physiological research, yet underlying cellular mechanisms remain poorly understood. Gamma oscillations (30 to 80 hertz), a biomarker cognitive performance, require and potentiate glutamatergic transmission onto parvalbumin-positive interneurons (PVIs), suggesting interface for cell-to-network plasticity. In ex vivo local potential recordings, we demonstrate long-term potentiation hippocampal gamma power. obeys established rules PVI plasticity, requiring calcium-permeable AMPA receptors (CP-AMPARs) metabotropic glutamate (mGluRs). A microcircuit computational model CA3 predicts CP-AMPAR PVIs critically outperforms pyramidal cell in increasing power completely accounts potentiation. We reaffirm this three PVI-targeting animal models, demonstrating that requires PVI-specific signaling via Gq/PKC pathway comprising mGluR5 Gi-sensitive, PKA-dependent pathway. activity-dependent, metabotropically mediated on may serve as guiding principle understanding network health disease.

Language: Английский

Citations

9