Information content of note transitions in the music of J. S. Bach DOI Creative Commons
S. R. Kulkarni,

Sophia U. David,

Christopher W. Lynn

et al.

Physical Review Research, Journal Year: 2024, Volume and Issue: 6(1)

Published: Feb. 2, 2024

Music has a complex structure that expresses emotion and conveys information. Humans process information through imperfect cognitive instruments produce gestalt, smeared version of reality. How can we quantify the contained in piece music? Further, what is inferred by human, how does relate to (and differ from) true piece? To tackle these questions quantitatively, present framework study conveyed musical constructing analyzing networks formed notes (nodes) their transitions (edges). Using this framework, analyze music composed J. S. Bach lens network science theory. Regarded as one greatest composers Western tradition, Bach's work highly mathematically structured spans wide range compositional forms, such fugues choral pieces. Conceptualizing each composition note transitions, find different kinds compositions be grouped together according content structure. Moreover, communicate large amounts while maintaining small deviations from network, suggesting they are for efficient communication We probe structures enable rapid information--namely, high heterogeneity strong clustering. Taken together, our findings shed new light on properties compositions. More generally, serves stepping stone exploring complexities, creativity systems.

Language: Английский

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex DOI Creative Commons
Justine Y. Hansen, Golia Shafiei, Ross D. Markello

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(11), P. 1569 - 1581

Published: Oct. 27, 2022

Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative 19 transporters across nine different neurotransmitter systems. We found that profiles align with structural connectivity mediate function, including neurophysiological oscillatory dynamics resting-state hemodynamic functional connectivity. Using Neurosynth cognitive atlas, uncovered topographic gradient overlapping distributions separates extrinsic intrinsic psychological processes. Finally, both expected novel associations between cortical abnormality patterns 13 disorders. replicated all findings an independently collected autoradiography dataset. This work demonstrates chemoarchitecture shapes brain structure providing new direction for studying multi-scale organization.

Language: Английский

Citations

412
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight DOI
Jacob W. Vogel, Nick Corriveau‐Lecavalier, Nicolai Franzmeier

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(10), P. 620 - 639

Published: Aug. 24, 2023

Language: Английский

Citations

77
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities DOI Creative Commons
Justine Y. Hansen, Golia Shafiei, Jacob W. Vogel

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 10, 2022

Abstract Numerous brain disorders demonstrate structural abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these connectomic vulnerabilities remain unknown, has yet be studied in a single multi-disorder framework. Using MRI morphometry the ENIGMA consortium, we construct maps cortical abnormalities for thirteen neurodevelopmental, neurological, psychiatric N = 21,000 participants 26,000 controls, collected using harmonised processing protocol. We systematically compare multiple micro-architectural measures, including gene expression, neurotransmitter density, metabolism, myelination (molecular vulnerability), as well global measures number connections, centrality, connection diversity (connectomic vulnerability). find relationship between vulnerability white-matter architecture that drives disorder profiles. Local attributes, particularly receptor profiles, constitute best predictors both disorder-specific morphology cross-disorder similarity. Finally, consistently subtended by small subset network epicentres bilateral sensory-motor, inferior temporal lobe, precuneus, superior parietal cortex. Collectively, our results highlight how local attributes connectivity jointly shape abnormalities.

Language: Английский

Citations

70
A spatiotemporal complexity architecture of human brain activity DOI Creative Commons
Stephan Krohn, Nina von Schwanenflug, Leonhard Waschke

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(5)

Published: Feb. 1, 2023

The human brain operates in large-scale functional networks. These networks are an expression of temporally correlated activity across regions, but how global network properties relate to the neural dynamics individual regions remains incompletely understood. Here, we show that brain's architecture is tightly linked critical episodes regularity, visible as spontaneous "complexity drops" magnetic resonance imaging signals. closely explain connectivity strength between subserve propagation patterns, and reflect interindividual differences age behavior. Furthermore, complexity drops define states dynamically shape strength, topological configuration, hierarchy comprehensively known structure-function relationships within brain. findings delineate a principled activity-a "complexome" underpins organization.

Language: Английский

Citations

38
Towards a biologically annotated brain connectome DOI
Vincent Bazinet, Justine Y. Hansen, Bratislav Mišić

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 747 - 760

Published: Oct. 17, 2023

Language: Английский

Citations

38
Statistical power in network neuroscience DOI

Koen Helwegen,

Ilan Libedinsky, Martijn P. van den Heuvel

et al.

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(3), P. 282 - 301

Published: Jan. 30, 2023

Language: Английский

Citations

35
In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape DOI Creative Commons
Andrea I. Luppi, Justine Y. Hansen, R. Adapa

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(24)

Published: June 14, 2023

To understand how pharmacological interventions can exert their powerful effects on brain function, we need to they engage the brain's rich neurotransmitter landscape. Here, bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating regional distribution of 19 receptors transporters obtained from positron emission tomography, changes in magnetic resonance imaging connectivity 10 different mind-altering drugs: propofol, sevoflurane, ketamine, lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), ayahuasca, 3,4-methylenedioxymethamphetamine (MDMA), modafinil, methylphenidate. Our results reveal a many-to-many mapping between psychoactive drugs' function multiple systems. The both anesthetics psychedelics are organized along hierarchical gradients structure function. Last, show that co-susceptibility recapitulates disorder-induced structural alterations. Collectively, these highlight statistical patterns drug-induced reorganization architecture.

Language: Английский

Citations

32
Neurophysiological signatures of cortical micro-architecture DOI Creative Commons
Golia Shafiei, Ben Fulcher, Bradley Voytek

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 26, 2023

Abstract Systematic spatial variation in micro-architecture is observed across the cortex. These micro-architectural gradients are reflected neural activity, which can be captured by neurophysiological time-series. How spontaneous dynamics organized cortex and how they arise from heterogeneous cortical remains unknown. Here we extensively profile regional human brain estimating over 6800 time-series features resting state magnetoencephalography (MEG) signal. We then map profiles to a comprehensive multi-modal, multi-scale atlas of micro-architecture, including microstructure, metabolism, neurotransmitter receptors, cell types laminar differentiation. find that dominant axis reflects characteristics power spectrum density linear correlation structure signal, emphasizing importance conventional electromagnetic while identifying additional informative have traditionally received less attention. Moreover, co-localized with multiple features, gene expression gradients, intracortical myelin, receptors transporters, oxygen glucose metabolism. Collectively, this work opens new avenues for studying anatomical basis activity.

Language: Английский

Citations

32
A synergistic workspace for human consciousness revealed by Integrated Information Decomposition DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 25, 2023

How is the information-processing architecture of human brain organised, and how does its organisation support consciousness? Here, we combine network science a rigorous information-theoretic notion synergy to delineate ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across brain. This then integrated within workspace widely distributed via broadcaster regions. Through functional MRI analysis, show correspond brain’s default mode network, whereas broadcasters coincide with executive control network. We find loss consciousness due general anaesthesia or disorders corresponds diminished ability integrate information, which restored upon recovery. Thus, coincides breakdown integration work contributes conceptual empirical reconciliation between two prominent scientific theories consciousness, Global Neuronal Workspace Integrated Information Theory, while also advancing our understanding supports through information.

Language: Английский

Citations

31
Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease DOI Creative Commons
Justine Y. Hansen, Golia Shafiei, Katharina Voigt

et al.

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(9), P. e3002314 - e3002314

Published: Sept. 25, 2023

The brain is composed of disparate neural populations that communicate and interact with one another. Although fiber bundles, similarities in molecular architecture, synchronized activity all reflect how regions potentially another, a comprehensive study these interregional relationships jointly structure function remains missing. Here, we systematically integrate 7 multimodal, multiscale types similarity ("connectivity modes") derived from gene expression, neurotransmitter receptor density, cellular morphology, glucose metabolism, haemodynamic activity, electrophysiology humans. We first show for connectivity modes, feature decreases distance increases when are structurally connected. Next, modes exhibit unique diverse connection patterns, hub profiles, spatial gradients, modular organization. Throughout, observe consistent primacy modes-namely correlated expression similarity-that map onto multiple phenomena, including the rich club patterns abnormal cortical thickness across 13 neurological, psychiatric, neurodevelopmental disorders. Finally, to construct single multimodal wiring human cortex, fuse fused network maps major organizational features cortex structural connectivity, intrinsic functional networks, cytoarchitectonic classes. Altogether, this work contributes integrative cerebral cortex.

Language: Английский

Citations

27