Modular Satellite Nanoparticles for Remedying Primary and Secondary Injury in Cerebral Ischemia‐Reperfusion

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: March 27, 2024

Abstract Reperfusion therapy, employed in the treatment of acute stroke, frequently proves to be inadequate addressing primary brain tissue injury and may even give rise secondary damage. The study introduces a satellite nanoparticle platform named MEps, which combine neural repair properties bone marrow mesenchymal stem cell exosomes (Exos) with inflammatory site‐targeting abilities macrophage membranes (MMs). MMs Exos MEps act like satellites, ensuring precise positioning information transmission. rapidly form protective barrier on damaged cerebral vascular endothelial cells through interaction adhesion molecules their receptors, blocking infiltration neutrophils. Subsequently, factors initiate neurogenesis. results indicate that this innovative approach effectively mitigates ischemic‐reperfusion at multiple levels demonstrates strong biocompatibility. This strategy holds promise for clinical applications alleviating injury.

Language: Английский

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General In Situ Engineering of Carbon‐Based Materials on Carbon Fiber for In Vivo Neurochemical Sensing

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(36)

Published: June 20, 2024

Developing real-time, dynamic, and in situ analytical methods with high spatial temporal resolutions is crucial for exploring biochemical processes the brain. Although vivo electrochemical based on carbon fiber (CF) microelectrodes are effective monitoring neurochemical dynamics during physiological pathological processes, complex post modification hinders large-scale productions widespread neuroscience applications. Herein, we develop a general strategy engineering of carbon-based materials to mass-produce functional CFs by introducing polydopamine anchor zeolitic imidazolate frameworks as precursors, followed one-step pyrolysis. This demonstrates exceptional universality design flexibility, overcoming post-modification procedures avoiding delamination layer. simplifies fabrication integration CF-based microelectrodes. Moreover, highly stable selective H

Language: Английский

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Peripheral immunity is associated with cognitive impairment after acute minor ischemic stroke and transient ischemic attack

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 13, 2024

Abstract Immunoinflammation is associated with the development of post-stroke cognitive impairment (PSCI), however, peripheral immunity has not been fully explored. We aimed to investigate association between PSCI and immune indicators, including neutrophil, lymphocyte, mononuclear percentages counts; systemic inflammation index; platelet-to-lymphocyte ratio; neutrophil-to-lymphocyte ratio (NLR); lymphocyte-to-monocyte ratio. A total 224 patients acute minor ischemic stroke or transient attack 6–12 months follow-up were included. was defined as a Montreal Cognitive Assessment score < 22 during period. performed logistic regression, subgroup analyses based on age sex, further established predictive models. found that increased innate indicators (neutrophils, neutrophil percentage) risk PSCI, whereas adaptive indicator (lymphocytes) protective against especially in aged 50–65 years. Neutrophil percentage NLR improved efficacy models included demographic, clinical, imaging information, area under curve from 0.765 0.804 0.803 ( P = 0.042 0.049, respectively). conducted comprehensive analysis providing novel perspective early detection, etiology, treatment PSCI.

Language: Английский

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Lactate modulates microglial inflammatory responses through HIF-1α-mediated CCL7 signaling after cerebral ischemia in mice

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113801 - 113801

Published: Dec. 15, 2024

Language: Английский

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Molecular Engineering of 2′, 7′‐Dichlorofluorescein to Unlock Efficient Superoxide Anion NIR‐II Fluorescent Imaging and Tumor Photothermal Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Abstract Although classical fluorescent dyes feature advantages of high quantum yield, tunable “OFF‐ON” fluorescence, and modifiable chemical structures, etc., their bio‐applications in deep tissue remains challenging due to excessively short emission wavelength (that may lead superficial penetration depth). Therefore, there is a pressing need for pushing the from visible region NIR‐II window. As representative dye, 2′,7′‐Dichlorofluorescein ( DCF ), derivative Fluorescein, selected rationally engineered develop novel platform, CR‐OH , which exhibits substantial red‐shift region. This achievement attributed molecular modification strategies that include extending π‐conjugation, enhancing rigidity, incorporating strong electron‐withdrawing groups. Furthermore, based on this developed fluorescence probe photothermal nanoagent are successfully constructed unlock its bio‐application imaging endogenous O 2 ·– fluctuations CIRI model first time, as well effective therapy 4T1 tumors with conversion efficiency (44.0%). Significantly, work overcomes limitation dyes, effectively unlocking applications diagnosis treatment early disease

Language: Английский

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

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Anti-neuroinflammatory agent rhein lysinate-based self-assembled injectable hydrogel loaded with ZL006 for promoting post-stroke functional recovery

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123124 - 123124

Published: Jan. 1, 2025

Language: Английский

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Polyphenylalanine-Baicalein Nanomicelles Reduce Nerve Cell Apoptosis and Inflammation to Enhance Neuroprotection and Poststroke Rehabilitation

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Cerebral ischemic stroke, neuronal death, and inflammation bring difficulties in neuroprotection rehabilitation. In this study, we developed designed the ability of natural lactoferrin-polyethylene glycol-polyphenylalanine-baicalein nanomicelles (LF-PEG-PPhe-Bai) to target reduce these pathological processes, such as neurological damage cognitive impairment stages poststroke. Nanomicelles made from biocompatible materials have improved bioavailability targeted distribution afflicted brain areas. The results showed that LF-PEG-PPhe-Bai greatly antioxidation, antiapoptosis, anti-inflammation activity vitro. Meanwhile, behavioral 2-VO model mice, protected nerve cells hippocampus, reduced at injury site vivo. conclusion, are employed for enhancing poststroke development technology might provide a new technique neural repair after ischemia future.

Language: Английский

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Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115177 - 115177

Published: Feb. 7, 2025

Language: Английский

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Counteracting immunodepression by extracellular matrix hydrogel to promote brain tissue remodeling and neurological function recovery after traumatic brain injury

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123181 - 123181

Published: Feb. 8, 2025

Language: Английский

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