Functional characterization of the dural sinuses as a neuroimmune interface

Cell, Journal Year: 2021, Volume and Issue: 184(4), P. 1000 - 1016.e27

Published: Jan. 27, 2021

Language: Английский

---

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

Science, Journal Year: 2021, Volume and Issue: 373(6553)

Published: June 3, 2021

The meninges are a membranous structure enveloping the central nervous system (CNS) that host rich repertoire of immune cells mediating CNS surveillance. Here, we report mouse contain pool monocytes and neutrophils supplied not from blood but by adjacent skull vertebral bone marrow. Under pathological conditions, including spinal cord injury neuroinflammation, CNS-infiltrating myeloid can originate brain borders display transcriptional signatures distinct their blood-derived counterparts. Thus, populated marrow niches, strategically placed to supply innate under homeostatic conditions. These findings call for reinterpretation immune-cell infiltration into during autoimmunity may inform future therapeutic approaches harness meningeal cells.

Language: Английский

---

The Brain’s Glymphatic System: Current Controversies

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(7), P. 458 - 466

Published: May 15, 2020

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within central nervous system (CNS). Imaging studies, as well manipulations transport, point to a key role glymphatic-lymphatic clearance amyloid-β and other proteins. As such, represents new target combating neurodegenerative diseases. Not unexpectedly, introduction plumbing brain has stirred controversies. This opinion article will highlight what we know about brain's transport systems, where experimental data are lacking, still debated.

Language: Английский

---

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

Nature, Journal Year: 2020, Volume and Issue: 577(7792), P. 689 - 694

Published: Jan. 15, 2020

Language: Английский

---

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

Nature Neuroscience, Journal Year: 2018, Volume and Issue: 22(2), P. 317 - 327

Published: Dec. 20, 2018

Language: Английский

---

The Meningeal Lymphatic System: A New Player in Neurophysiology

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 375 - 388

Published: Oct. 1, 2018

Language: Английский

---

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

Nature, Journal Year: 2019, Volume and Issue: 568(7751), P. 187 - 192

Published: April 1, 2019

Language: Английский

---

Physiological blood–brain transport is impaired with age by a shift in transcytosis

Nature, Journal Year: 2020, Volume and Issue: 583(7816), P. 425 - 430

Published: July 1, 2020

Language: Английский

---

Sleep modulates haematopoiesis and protects against atherosclerosis

Nature, Journal Year: 2019, Volume and Issue: 566(7744), P. 383 - 387

Published: Feb. 13, 2019

Language: Английский

---

Biological functions of lymphatic vessels

Science, Journal Year: 2020, Volume and Issue: 369(6500)

Published: July 9, 2020

Roles of organ-specific lymphatic vessels Lymphatic are spread throughout the human body and have critical functions in mammalian physiology. Petrova et al. review emerging roles vasculature organ function pathology provide perspectives beyond traditional view maintenance fluid homeostasis. The authors highlight new insights into vessel endothelial cell biology as it relates to intestinal lacteals, lymph nodes, central nervous system meninges, cancer. Recent steps toward therapeutic opportunities that could alter or growth also discussed. Science , this issue p. eaax4063

Language: Английский

---