Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(41)
Published: July 18, 2023
Hydrogel-based
regenerated
scaffolds
show
promise
as
a
platform
for
neural
regeneration
following
spinal
cord
injury
(SCI).
Nevertheless,
the
persistent
problem
of
poor
mechanical
strength
and
limited
integration
with
host
tissue
still
exists.
In
this
study,
bioinspired
hydrogel
highly
sophisticated
features
after
SCI
is
developed.
The
composed
dihydroxyphenylalanine
(DOPA)-grafted
chitosan
designer
peptide,
offering
unique
set
qualities
such
being
injectable,
having
self-healing
abilities,
adhering
to
tissues.
Compared
conventional
hydrogels,
ensures
significant
promotion
immune
response
modulation
axon
regrowth
while
featuring
synapse
formation
various
neurotransmitters
myelin
regeneration.
Subsequently,
functional
recoveries
are
enhanced,
including
motor
function,
sensory
particularly
bladder
defect
repair.
These
positive
findings
demonstrate
that
has
great
potential
strategy
repairing
SCI.
Moreover,
versatility
goes
beyond
holds
in
other
contexts.
Overall,
proposed
represents
an
innovative
multifaceted
tool
engineering
structures
biomedical
field.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Sept. 28, 2021
Differential
expression
analysis
in
single-cell
transcriptomics
enables
the
dissection
of
cell-type-specific
responses
to
perturbations
such
as
disease,
trauma,
or
experimental
manipulations.
While
many
statistical
methods
are
available
identify
differentially
expressed
genes,
principles
that
distinguish
these
and
their
performance
remain
unclear.
Here,
we
show
relative
is
contingent
on
ability
account
for
variation
between
biological
replicates.
Methods
ignore
this
inevitable
biased
prone
false
discoveries.
Indeed,
most
widely
used
can
discover
hundreds
genes
absence
differences.
To
exemplify
principles,
exposed
true
discoveries
injured
mouse
spinal
cord.
Trends in Immunology,
Journal Year:
2020,
Volume and Issue:
41(9), P. 758 - 770
Published: Aug. 17, 2020
Astrocytes
are
neural
parenchymal
cells
that
ubiquitously
tile
the
central
nervous
system
(CNS).
In
addition
to
playing
essential
roles
in
healthy
tissue,
astrocytes
exhibit
an
evolutionarily
ancient
response
all
CNS
insults,
referred
as
astrocyte
reactivity.
Long
regarded
passive
and
homogeneous,
reactivity
is
being
revealed
a
heterogeneous
functionally
powerful
component
of
mammalian
innate
immunity.
Nevertheless,
concepts
about
what
comprises
it
does
incomplete
sometimes
controversial.
This
review
discusses
goal
differentiating
reactive
subtypes
states
based
on
composite
pictures
molecular
expression,
cell
morphology,
cellular
interactions,
proliferative
state,
normal
functions,
disease-induced
dysfunctions.
A
working
model
conceptual
framework
presented
for
characterizing
diversity
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: June 26, 2023
Abstract
Spinal
cord
injury
(SCI)
remains
a
severe
condition
with
an
extremely
high
disability
rate.
The
challenges
of
SCI
repair
include
its
complex
pathological
mechanisms
and
the
difficulties
neural
regeneration
in
central
nervous
system.
In
past
few
decades,
researchers
have
attempted
to
completely
elucidate
mechanism
identify
effective
strategies
promote
axon
circuit
remodeling,
but
results
not
been
ideal.
Recently,
new
SCI,
especially
interactions
between
immune
cell
responses,
revealed
by
single-cell
sequencing
spatial
transcriptome
analysis.
With
development
bioactive
materials
stem
cells,
more
attention
has
focused
on
forming
intermediate
networks
reconstruction
than
promoting
axonal
corticospinal
tract.
Furthermore,
technologies
control
physical
parameters
such
as
electricity,
magnetism
ultrasound
constantly
innovated
applied
fate
regulation.
Among
these
advanced
novel
technologies,
therapy,
biomaterial
transplantation,
electromagnetic
stimulation
entered
into
stage
clinical
trials,
some
them
already
treatment.
this
review,
we
outline
overall
epidemiology
pathophysiology
expound
latest
research
progress
related
detail,
propose
future
directions
for
applications.
Science,
Journal Year:
2021,
Volume and Issue:
374(6569), P. 848 - 856
Published: Nov. 11, 2021
Fibril
motion
improves
peptide
signaling
Artificial
scaffolds
that
bear
the
peptide-signaling
sequences
of
proteins
for
tissue
regeneration
often
have
limited
effectiveness.
Álvarez
et
al
.
synthesized
supramolecular
fibril
bearing
two
promote
nerve
regeneration,
one
reduces
glial
scarring
and
another
promotes
blood
vessel
formation
(see
Perspective
by
Wojciechowski
Stevens).
In
a
mouse
model
paralyzing
human
spinal
cord
injury,
mutations
in
tetrapeptide
domain
outside
regions
improved
recovery
promoting
intense
within
fibrils.
The
mutation
with
most
dynamics
resulted
corticospinal
axon
regrowth
myelination,
functional
revascularization,
motor
neuron
survival.
—PDS
