Dopamine signaling in the dorsomedial striatum promotes compulsive behavior DOI Creative Commons
Jillian L. Seiler, Caitlin V. Cosme, Venus N. Sherathiya

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(5), P. 1175 - 1188.e5

Published: Feb. 7, 2022

Compulsive behavior is a defining feature of disorders such as substance use disorders. Current evidence suggests that corticostriatal circuits control the expression established compulsions, but little known about mechanisms regulating development compulsions. We hypothesized dopamine, critical modulator striatal synaptic plasticity, could alterations in leading to compulsions (defined here continued reward seeking face punishment). used dual-site fiber photometry measure dopamine axon activity dorsomedial striatum (DMS) and dorsolateral (DLS) emerged. Individual variability speed with which emerged was predicted by DMS activity. Amplifying this signal accelerated animals' transitions compulsion, whereas inhibition delayed it. In contrast, amplifying DLS signaling had no effect on emergence These results establish key controller compulsive seeking.

Language: Английский

The Interaction of Person-Affect-Cognition-Execution (I-PACE) model for addictive behaviors: Update, generalization to addictive behaviors beyond internet-use disorders, and specification of the process character of addictive behaviors DOI Creative Commons
Matthias Brand, Elisa Wegmann, Rudolf Stark

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 104, P. 1 - 10

Published: June 24, 2019

We propose an updated version of the Interaction Person-Affect-Cognition-Execution (I-PACE) model, which we argue to be valid for several types addictive behaviors, such as gambling, gaming, buying-shopping, and compulsive sexual behavior disorders. Based on recent empirical findings theoretical considerations, that behaviors develop a consequence interactions between predisposing variables, affective cognitive responses specific stimuli, executive functions, inhibitory control decision-making. In process associations cue-reactivity/craving diminished contribute development habitual behaviors. An imbalance structures fronto-striatal circuits, particularly ventral striatum, amygdala, dorsolateral prefrontal areas, may relevant early stages dorsal striatum later processes. The I-PACE model provide foundation future studies clinical practice. Future should investigate common unique mechanisms involved in addictive, obsessive-compulsive-related, impulse-control, substance-use

Language: Английский

Citations

1149
The Neuroscience of Drug Reward and Addiction DOI
Nora D. Volkow, Michael Michaelides, Rubén Baler

et al.

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 2115 - 2140

Published: Sept. 11, 2019

Drug consumption is driven by a drug's pharmacological effects, which are experienced as rewarding, and influenced genetic, developmental, psychosocial factors that mediate drug accessibility, norms, social support systems or lack thereof. The reinforcing effects of drugs mostly depend on dopamine signaling in the nucleus accumbens, chronic exposure triggers glutamatergic-mediated neuroadaptations striato-thalamo-cortical (predominantly prefrontal cortical regions including orbitofrontal cortex anterior cingulate cortex) limbic pathways (amygdala hippocampus) that, vulnerable individuals, can result addiction. In parallel, changes extended amygdala negative emotional states perpetuate taking an attempt to temporarily alleviate them. Counterintuitively, addicted person, actual associated with attenuated increase brain reward regions, might contribute drug-taking behavior compensate for difference between magnitude expected triggered conditioning cues experience it. Combined, these enhanced motivation "seek drug" (energized increases cues) impaired top-down self-regulation favors compulsive against backdrop emotionality interoceptive awareness "drug hunger." Treatment interventions intended reverse show promise therapeutic approaches

Language: Английский

Citations

598
The transition to compulsion in addiction DOI
Christian Lüscher, Trevor W. Robbins, Barry J. Everitt

et al.

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(5), P. 247 - 263

Published: March 30, 2020

Language: Английский

Citations

383
The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms DOI Creative Commons
Eric J. Nestler, Christian Lüscher

Neuron, Journal Year: 2019, Volume and Issue: 102(1), P. 48 - 59

Published: April 1, 2019

Language: Английский

Citations

285
Addiction as a brain disease revised: why it still matters, and the need for consilience DOI Creative Commons
Markus Heilig, James MacKillop, Diana Martínez

et al.

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 46(10), P. 1715 - 1723

Published: Feb. 22, 2021

The view that substance addiction is a brain disease, although widely accepted in the neuroscience community, has become subject to acerbic criticism recent years. These criticisms state disease deterministic, fails account for heterogeneity remission and recovery, places too much emphasis on compulsive dimension of addiction, specific neural signature not been identified. We acknowledge some these have merit, but assert foundational premise neurobiological basis fundamentally sound. also emphasize denying harmful standpoint since it contributes reducing access healthcare treatment, consequences which are catastrophic. Here, we therefore address criticisms, doing so provide contemporary update addiction. arguments support this view, discuss why apparently spontaneous does negate it, how seemingly behaviors can co-exist with sensitivity alternative reinforcement Most importantly, argue biological substrate from both capacity behavior change arise, arguing an intensified neuroscientific study recovery. More broadly, propose disagreements reveal need multidisciplinary research integrates neuroscientific, behavioral, clinical, sociocultural perspectives.

Language: Английский

Citations

206
Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond DOI
Walid Bouthour, Pierre Mégevand, John P. Donoghue

et al.

Nature Reviews Neurology, Journal Year: 2019, Volume and Issue: 15(6), P. 343 - 352

Published: April 1, 2019

Language: Английский

Citations

185
Improving translation of animal models of addiction and relapse by reverse translation DOI
Marco Vènniro, Matthew L. Banks, Markus Heilig

et al.

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(11), P. 625 - 643

Published: Oct. 6, 2020

Language: Английский

Citations

181
The mouse prefrontal cortex: Unity in diversity DOI Creative Commons
Pierre Le Merre, Sofie Ährlund‐Richter, Marie Carlén

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(12), P. 1925 - 1944

Published: April 23, 2021

Language: Английский

Citations

153
Dorsal Striatal Circuits for Habits, Compulsions and Addictions DOI Creative Commons

David M. Lipton,

Ben J. Gonzales,

Ami Citri

et al.

Frontiers in Systems Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: July 18, 2019

Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors which are all characterized by relatively automatic action performance. We discuss relevant studies, primarily from rodent literature, describe how major headway has been made in identifying brain regions cell types whose activity is modulated during acquisition performance these automated behaviors. The dorsal striatum cortical inputs to this structure have emerged as key players wider basal ganglia circuitry encoding behavioral automaticity, changes different neuronal cell-types shown co-occur with formation highlight disordered functioning circuits can result neuropsychiatric disorders, such obsessive-compulsive disorder (OCD) drug addiction. Finally, next phase research field may benefit integration approaches for access cells based on their genetic makeup, activity, connectivity precise anatomical location.

Language: Английский

Citations

148
Mesolimbic dopamine adapts the rate of learning from action DOI Creative Commons
Luke T. Coddington, Sarah Lindo, Joshua T. Dudman

et al.

Nature, Journal Year: 2023, Volume and Issue: 614(7947), P. 294 - 302

Published: Jan. 18, 2023

Abstract Recent success in training artificial agents and robots derives from a combination of direct learning behavioural policies indirect through value functions 1–3 . Policy use distinct algorithms that optimize performance reward prediction, respectively. In animals, the role mesolimbic dopamine signalling have been extensively evaluated with respect to prediction 4 ; however, so far there has little consideration how policy might inform our understanding 5 Here we used comprehensive dataset orofacial body movements understand evolved as naive, head-restrained mice learned trace conditioning paradigm. Individual differences initial dopaminergic responses correlated emergence policy, but not putative encoding for predictive cue. Likewise, physiologically calibrated manipulations produced several effects inconsistent predicted by neural-network-based model signals set an adaptive rate, error signal, learning. This work provides strong evidence phasic activity can regulate policies, expanding explanatory power reinforcement models animal 6

Language: Английский

Citations

87