Microsystems & Nanoengineering,
Journal Year:
2022,
Volume and Issue:
8(1)
Published: Dec. 22, 2022
Recording
neural
signals
from
delicate
autonomic
nerves
is
a
challenging
task
that
requires
the
development
of
low-invasive
interface
with
highly
selective,
micrometer-sized
electrodes.
This
paper
reports
on
three-dimensional
(3D)
protruding
thin-film
microelectrode
array
(MEA),
which
intended
to
be
used
for
recording
low-amplitude
pelvic
nervous
structures
by
penetrating
transversely
reduce
distance
axons.
Cylindrical
gold
pillars
(Ø
20
or
50
µm,
~60
µm
height)
were
fabricated
micromachined
polyimide
substrate
in
an
electroplating
process.
Their
sidewalls
insulated
parylene
C,
and
their
tips
optionally
modified
wet
etching
and/or
application
titanium
nitride
(TiN)
coating.
The
microelectrodes
these
combined
techniques
exhibited
low
impedances
(~7
kΩ
at
1
kHz
Ø
exposed
surface
area
~5000
µm²)
intrinsic
noise
levels.
functionalities
evaluated
ex
vivo
pilot
study
mouse
retinae,
spontaneous
neuronal
spikes
recorded
amplitudes
up
66
µV.
novel
process
strategy
fabricating
flexible,
3D
interfaces
low-impedance
has
potential
selectively
record
not
only
such
as
retinal
cells
but
also
improved
signal
quality
circuits
develop
stimulation
strategies
bioelectronic
medicine,
e.g.,
control
vital
digestive
functions.
Cambridge Quarterly of Healthcare Ethics,
Journal Year:
2023,
Volume and Issue:
32(4), P. 461 - 481
Published: May 15, 2023
The
rise
of
neurotechnologies,
especially
in
combination
with
artificial
intelligence
(AI)-based
methods
for
brain
data
analytics,
has
given
to
concerns
around
the
protection
mental
privacy,
integrity
and
cognitive
liberty
-
often
framed
as
"neurorights"
ethical,
legal,
policy
discussions.
Several
states
are
now
looking
at
including
neurorights
into
their
constitutional
legal
frameworks,
international
institutions
organizations,
such
UNESCO
Council
Europe,
taking
an
active
interest
developing
governance
guidelines
on
this
issue.
However,
many
discussions
philosophical
assumptions,
ethical
frames
reference
interpretation
either
not
made
explicit
or
conflict
each
other.
aim
multidisciplinary
work
is
provide
conceptual,
foundations
that
allow
facilitating
a
common
minimalist
conceptual
understanding
integrity,
facilitate
scholarly,
Cyborg and Bionic Systems,
Journal Year:
2023,
Volume and Issue:
4
Published: Jan. 1, 2023
Cross-frequency
coupling
(CFC)
reflects
(nonlinear)
interactions
between
signals
of
different
frequencies.
Evidence
from
both
patient
and
healthy
participant
studies
suggests
that
CFC
plays
an
essential
role
in
neuronal
computation,
interregional
interaction,
disease
pathophysiology.
The
present
review
discusses
methodological
advances
challenges
the
computation
with
particular
emphasis
on
potential
solutions
to
spurious
coupling,
inferring
intrinsic
rhythms
a
targeted
frequency
band,
causal
interferences.
We
specifically
focus
literature
exploring
context
cognition/memory
tasks,
sleep,
neurological
disorders,
such
as
Alzheimer's
disease,
epilepsy,
Parkinson's
disease.
Furthermore,
we
highlight
implication
for
optimization
invasive
noninvasive
neuromodulation
rehabilitation.
Mainly,
could
support
advancing
understanding
neurophysiology
cognition
motor
control,
serve
biomarker
symptoms,
leverage
therapeutic
interventions,
e.g.,
closed-loop
brain
stimulation.
Despite
evident
advantages
investigative
translational
tool
neuroscience,
further
improvements
are
required
facilitate
practical
correct
use
cyborg
bionic
systems
field.
Nature Nanotechnology,
Journal Year:
2024,
Volume and Issue:
19(4), P. 514 - 523
Published: Jan. 11, 2024
Abstract
One
of
the
critical
factors
determining
performance
neural
interfaces
is
electrode
material
used
to
establish
electrical
communication
with
tissue,
which
needs
meet
strict
electrical,
electrochemical,
mechanical,
biological
and
microfabrication
compatibility
requirements.
This
work
presents
a
nanoporous
graphene-based
thin-film
technology
its
engineering
form
flexible
interfaces.
The
developed
allows
fabrication
small
microelectrodes
(25
µm
diameter)
while
achieving
low
impedance
(∼25
kΩ)
high
charge
injection
(3–5
mC
cm
−
2
).
In
vivo
brain
recording
assessed
in
rodents
reveals
high-fidelity
recordings
(signal-to-noise
ratio
>10
dB
for
local
field
potentials),
stimulation
an
intrafascicular
implant
demonstrates
current
thresholds
(<100
µA)
selectivity
(>0.8)
activating
subsets
axons
within
rat
sciatic
nerve
innervating
tibialis
anterior
plantar
interosseous
muscles.
Furthermore,
tissue
biocompatibility
devices
was
validated
by
chronic
epicortical
(12
week)
intraneural
(8
implantation.
describes
microelectrode
potential
high-precision
high-resolution
interfacing.
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 15, 2025
Abstract
The
proliferation
of
wearable
biodevices
has
boosted
the
development
soft,
innovative,
and
multifunctional
materials
for
human
health
monitoring.
integration
sensors
with
intelligent
systems
is
an
overwhelming
tendency,
providing
powerful
tools
remote
monitoring
personal
management.
Among
many
candidates,
two-dimensional
(2D)
stand
out
due
to
several
exotic
mechanical,
electrical,
optical,
chemical
properties
that
can
be
efficiently
integrated
into
atomic-thin
films.
While
previous
reviews
on
2D
primarily
focus
conventional
configurations
like
graphene,
rapid
new
opened
up
novel
applications,
particularly
in
smart
interaction
functionalities.
This
review
aims
consolidate
recent
progress,
highlight
unique
advantages
materials,
guide
future
research
by
discussing
existing
challenges
opportunities
applying
biodevices.
We
begin
in-depth
analysis
advantages,
sensing
mechanisms,
potential
applications
biodevice
fabrication.
Following
this,
we
systematically
discuss
state-of-the-art
based
various
physiological
signals
within
body.
Special
attention
given
showcasing
multi-functionality
devices,
mainly
including
self-power
supply,
diagnosis/treatment,
human–machine
interaction.
Finally,
concludes
a
concise
summary
prospective
solutions
concerning
utilization
advanced
