Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges

Cell stem cell, Journal Year: 2020, Volume and Issue: 27(4), P. 523 - 531

Published: Oct. 1, 2020

Language: Английский

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The evolutionary history of 2,658 cancers

Nature, Journal Year: 2020, Volume and Issue: 578(7793), P. 122 - 128

Published: Feb. 5, 2020

Cancer develops through a process of somatic evolution

Language: Английский

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Clonal hematopoiesis in human aging and disease

Science, Journal Year: 2019, Volume and Issue: 366(6465)

Published: Oct. 31, 2019

As people age, their tissues accumulate an increasing number of somatic mutations. Although most these mutations are little or no functional consequence, a mutation may arise that confers fitness advantage on cell. When this process happens in the hematopoietic system, substantial proportion circulating blood cells derive from single mutated stem This outgrowth, called "clonal hematopoiesis," is highly prevalent elderly population. Here we discuss recent advances our knowledge clonal hematopoiesis, its relationship to malignancies, link nonmalignant diseases aging, and potential impact immune function. Clonal hematopoiesis provides glimpse into selection likely occurs all tissues.

Language: Английский

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p53: 800 million years of evolution and 40 years of discovery

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(8), P. 471 - 480

Published: May 13, 2020

Language: Английский

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Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Nature Genetics, Journal Year: 2020, Volume and Issue: 52(11), P. 1219 - 1226

Published: Oct. 26, 2020

Language: Английский

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Tobacco smoking and somatic mutations in human bronchial epithelium

Nature, Journal Year: 2020, Volume and Issue: 578(7794), P. 266 - 272

Published: Jan. 29, 2020

Language: Английский

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The mutational landscape of normal human endometrial epithelium

Nature, Journal Year: 2020, Volume and Issue: 580(7805), P. 640 - 646

Published: April 22, 2020

Language: Английский

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Lung adenocarcinoma promotion by air pollutants

Nature, Journal Year: 2023, Volume and Issue: 616(7955), P. 159 - 167

Published: April 5, 2023

Language: Английский

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Hallmarks of Health

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 33 - 63

Published: Dec. 18, 2020

Language: Английский

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The evolutionary dynamics and fitness landscape of clonal hematopoiesis

Science, Journal Year: 2020, Volume and Issue: 367(6485), P. 1449 - 1454

Published: March 26, 2020

Evolutionary dynamics in hematopoiesis Cells accumulate mutations as we age, and these can be a source of diseases such cancer. How cells containing evolve, are maintained, proliferate within the body has not been well characterized. Using quantitative framework, Watson et al. applied population genetic theory to estimate mutation accumulation blood from sequencing data derived nearly 50,000 healthy individuals (see Perspective by Curtis). By evaluating how differ between cell populations, phenomenon known clonal hematopoiesis, researchers could observe recurrent drive certain lineages high frequencies an individual. The risk specific mutations, some which associated with leukemias, rising may therefore function cellular selection age at originated. Science , this issue p. 1449 ; see also 1426

Language: Английский

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