BMEMat,
Journal Year:
2023,
Volume and Issue:
1(3)
Published: July 19, 2023
Abstract
Cell
therapy
has
revolutionized
the
treatment
of
various
diseases,
such
as
cancers,
genetic
disorders,
and
autoimmune
diseases.
Currently,
most
cell
products
rely
on
ex
vivo
engineering,
which
requires
sophisticated
manufacturing
processes
poses
safety
concerns.
The
implementation
in
situ
holds
potential
to
overcome
current
limitations
provides
a
broad
range
applications
clinical
feasibility
future.
A
variety
biomaterials
have
been
developed
improve
function
target
delivery
specific
types
due
their
excellent
biocompatibility,
tunable
properties,
other
functionalities,
provide
reliable
method
achieve
modulation
reprogramming.
In
this
article,
we
summarize
recent
advances
for
including
T
cells,
macrophages,
dendritic
stem
cells
reprogramming
leveraging
lipid
nanoparticles,
polymers,
inorganic
materials,
biomaterials.
Finally,
discuss
challenges
future
perspectives
therapy.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Aug. 6, 2021
Reactive
oxygen
species
(ROS),
superoxide
anion
and
hydrogen
peroxide,
are
generated
as
byproducts
of
oxidative
phosphorylation
in
the
mitochondria
or
via
cell
signaling-induced
NADPH
oxidases
cytosol.
In
recent
two
decades,
a
plethora
studies
established
that
elevated
ROS
levels
by
eustress
crucial
physiological
mediators
many
cellular
developmental
processes.
this
review,
we
discuss
mechanisms
generation
regulation,
current
understanding
functions
maintenance
adult
embryonic
stem
cells,
well
process
reprogramming
to
pluripotent
state.
Recently
discovered
cell-non-autonomous
mediated
growth
factors
for
controlling
differentiation
immune
response
Drosophila
.
Importantly,
may
allow
deciphering
analogous
processes
human,
which
could
potentially
lead
development
novel
therapeutic
approaches
ROS-associated
diseases
treatment.
Regenerative Therapy,
Journal Year:
2021,
Volume and Issue:
16, P. 63 - 72
Published: Feb. 6, 2021
Due
to
traffic
accidents,
injuries,
burns,
congenital
malformations
and
other
reasons,
a
large
number
of
patients
with
tissue
or
organ
defects
need
urgent
treatment
every
year.
The
shortage
donors,
graft
rejection
problems
cause
deficient
supply
for
replacement,
repair
regeneration
patients,
so
regenerative
medicine
came
into
being.
Stem
cell
therapy
plays
an
important
role
in
the
field
medicine,
but
it
is
difficult
fill
by
injection
alone.
scientists
combine
three-dimensional
(3D)
printed
bone
engineering
scaffolds
stem
cells
achieve
desired
effect.
These
can
mimic
extracellular
matrix
(ECM),
cartilage,
eventually
form
functional
tissues
organs
providing
structural
support
promoting
attachment,
proliferation
differentiation.
This
paper
mainly
discussed
applications
3D
medicine.
application
examples
different
printing
technologies
raw
materials
are
introduced
compared.
Then
we
discuss
superiority
technology
over
traditional
methods,
put
forward
some
limitations,
look
future.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(14), P. 8102 - 8146
Published: Jan. 1, 2021
Magnetic
particle
imaging
(MPI)
has
recently
emerged
as
a
promising
non-invasive
technique.
Engineering
of
magnetic
nanoparticles
(MNPs)
is
effective
ways
to
enhance
MPI
sensitivity
and
spatial
resolution.
Cells,
Journal Year:
2021,
Volume and Issue:
10(9), P. 2319 - 2319
Published: Sept. 5, 2021
The
discovery
of
induced
pluripotent
stem
cells
(iPSCs)
has
made
an
invaluable
contribution
to
the
field
regenerative
medicine,
paving
way
for
identifying
true
potential
human
embryonic
(ESCs).
Since
controversy
around
ethicality
ESCs
continue
be
debated,
iPSCs
have
been
used
circumvent
process
destruction
embryo.
use
transformed
biological
research,
wherein
increasing
number
studies
are
documenting
nuclear
reprogramming
strategies
make
them
beneficial
models
drug
screening
as
well
disease
modelling.
flexibility
include
compatibility
non-invasive
harvesting,
and
ability
source
from
patients
with
rare
diseases.
widely
in
cardiac
modelling,
studying
inherited
arrhythmias,
neural
disorders
including
Alzheimer's
disease,
liver
spinal
cord
injury.
Extensive
research
factors
that
involved
maintaining
identity
during
induction
pluripotency
somatic
is
undertaken.
focus
current
review
detail
all
clinical
translation
strength
its
ever-growing
space.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
