Mechanisms and regulation of cholesterol homeostasis

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 21(4), P. 225 - 245

Published: Dec. 17, 2019

Language: Английский

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Immunotherapies for hepatocellular carcinoma

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 19(3), P. 151 - 172

Published: Nov. 11, 2021

Language: Английский

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Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities

Nature Metabolism, Journal Year: 2020, Volume and Issue: 2(2), P. 132 - 141

Published: Feb. 10, 2020

Language: Английский

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Targeted therapy for hepatocellular carcinoma

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Aug. 11, 2020

Abstract The last 3 years have seen the emergence of promising targeted therapies for treatment hepatocellular carcinoma (HCC). Sorafenib has been mainstay a decade and newer modalities were ineffective did not confer any increased therapeutic benefit until introduction lenvatinib which was approved based on its non-inferiority to sorafenib. subsequent success regorafenib in HCC patients who progress sorafenib heralded new era second-line quickly followed by ramucirumab, cabozantinib, most influential, immune checkpoint inhibitors (ICIs). Over same period combination therapies, including anti-angiogenesis agents with ICIs, dual ICIs conjunction surgery or other loco-regional extensively investigated shown promise provided basis exciting clinical trials. Work continues develop additional novel could potentially augment presently available options understand underlying mechanisms responsible drug resistance, goal improving survival HCC.

Language: Английский

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iProX in 2021: connecting proteomics data sharing with big data

Nucleic Acids Research, Journal Year: 2021, Volume and Issue: 50(D1), P. D1522 - D1527

Published: Oct. 22, 2021

The rapid development of proteomics studies has resulted in large volumes experimental data. emergence big data platform provides the opportunity to handle these amounts integrated proteome resource, iProX (https://www.iprox.cn), which was initiated 2017, been greatly improved with an up-to-date implemented 2021. Here, we describe main developments since its first publication Nucleic Acids Research 2019. First, a hyper-converged architecture high scalability supports submission process. A hadoop cluster can store datasets, and distributed, RESTful-styled Elastic Search engine query millions records within one second. Also, several new features, including Universal Spectrum Identifier (USI) mechanism proposed by ProteomeXchange, RESTful Web Service API, high-efficiency reanalysis pipeline, have added for better open sharing. By end August 2021, 1526 datasets had submitted iProX, reaching total volume 92.42TB. With implementation platform, support PB-level storage, hundreds billions spectra records, second-level latency service capabilities that meet requirements fast growing field proteomics.

Language: Английский

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Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 159, P. 245 - 293

Published: Jan. 1, 2020

With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics, lipids are emerging as central players in cancer biology. Lipids function essential building blocks for membranes, serve fuel drive energy-demanding processes and play a key role signaling molecules regulators numerous cellular functions. Not unexpectedly, cells, well other cell types tumor microenvironment, exploit various ways acquire extensively rewire their metabolism part plastic context-dependent metabolic reprogramming that is driven by both oncogenic environmental cues. The resulting changes fate composition help cells thrive changing microenvironment supporting functions hallmarks, energetics, promoting feedforward signaling, resisting oxidative stresses, regulating intercellular communication immune responses. Supported close connection between altered lipid pathogenic process, specific profiles unique disease biomarkers, with diagnostic, prognostic predictive potential. Multiple preclinical studies illustrate translational promise exploiting cancer, critically, have shown context dependent actionable vulnerabilities can be rationally targeted, particularly combinatorial approaches. Moreover, themselves used membrane disrupting agents or components nanocarriers therapeutics. number compounds strategies approaching clinical trials, we at doorstep hitherto underappreciated hallmark promising target oncologist's strategy combat cancer.

Language: Английский

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Integrative Proteomic Characterization of Human Lung Adenocarcinoma

Cell, Journal Year: 2020, Volume and Issue: 182(1), P. 245 - 261.e17

Published: July 1, 2020

Language: Английский

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Advances in Toxicological Research of the Anticancer Drug Cisplatin

Chemical Research in Toxicology, Journal Year: 2019, Volume and Issue: 32(8), P. 1469 - 1486

Published: July 29, 2019

Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in clinic due to its high efficacy and broad spectrum. The antineoplastic activity cisplatin mainly ability cross-link with DNA, thus blocking transcription replication. Unfortunately, clinical use limited by severe, dose-dependent toxic side effects. There are approximately 40 specific toxicities cisplatin, among which nephrotoxicity common one. Other effects include ototoxicity, neurotoxicity, gastrointestinal toxicity, hematological cardiotoxicity, hepatotoxicity. These together reduce life quality patients require lowering dosage drug, even stopping administration, weakening treatment effect. Few effective measures exist clinically against these because exact mechanisms from remain still unclear. Therefore, substantial effort has been made explore complicated biochemical processes involved toxicology aiming identify ways or eradicate toxicity. This review summarizes reviews updated advances toxicological research cisplatin. We anticipate provide insights into understanding underlying designing comprehensive therapeutic strategies involving

Language: Английский

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Data‐Independent Acquisition Mass Spectrometry‐Based Proteomics and Software Tools: A Glimpse in 2020

PROTEOMICS, Journal Year: 2020, Volume and Issue: 20(17-18)

Published: April 10, 2020

This review provides a brief overview of the development data-independent acquisition (DIA) mass spectrometry-based proteomics and selected DIA data analysis tools. Various schemes for are summarized first including Shotgun-CID, DIA, MSE , PAcIFIC, AIF, SWATH, MSX, SONAR, WiSIM, BoxCar, Scanning diaPASEF, PulseDIA, as well spectrometers enabling these methods. Next, software tools classified into three groups: library-based tools, library-free statistical validation The approaches reviewed generating spectral libraries six which tested by authors, OpenSWATH, Spectronaut, Skyline, PeakView, DIA-NN, EncyclopeDIA. An increasing number developed DIA-Umpire, Group-DIA, PECAN, PEAKS, facilitate identification novel proteoforms. authors share their user experience when to use DIA-MS, several Finally, state art spectrometry authors' views future directions summarized.

Language: Английский

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Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma

Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(1), P. 61 - 79

Published: Jan. 2, 2023

Language: Английский

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