The role of lipid metabolic reprogramming in tumor microenvironment DOI Creative Commons
Kai Yang, Xiaokun Wang, Chenghu Song

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1774 - 1808

Published: Jan. 1, 2023

Metabolic reprogramming is one of the most important hallmarks malignant tumors.Specifically, lipid metabolic has marked impacts on cancer progression and therapeutic response by remodeling tumor microenvironment (TME).In past few decades, immunotherapy revolutionized treatment landscape for advanced cancers.Lipid plays pivotal role in regulating immune to immunotherapy.Here, we systematically reviewed characteristics, mechanism, cells TME, appraised effects various cell death modes (specifically ferroptosis) metabolism, summarized antitumor therapies targeting metabolism.Overall, profound microenvironment; therefore, may lead development innovative clinical applications including sensitizing immunotherapy.

Language: Английский

The cancer metabolic reprogramming and immune response DOI Creative Commons

Longzheng Xia,

Linda Oyang,

Jinguan Lin

et al.

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Feb. 5, 2021

The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant the antitumor response in cancer. Increased evidence suggests that metabolism not only plays crucial role signaling for sustaining tumorigenesis survival, but also has wider implications regulation through both release metabolites affecting expression molecules, such as lactate, PGE2, arginine, etc. Actually, this energetic interplay between tumor leads to competition ecosystem, limiting nutrient availability leading microenvironmental acidosis, which hinders cell function. More interestingly, indispensable process maintaining self body homeostasis by various types cells. At present, more studies pointed out would undergo during proliferation, differentiation, execution effector functions, essential response. Herein, we discuss how regulate possible approaches targeting pathways context anticancer immunotherapy. We describe hypothetical combination treatments immunotherapy intervening could be used better unleash potential therapies.

Language: Английский

Citations

754
Cholesterol metabolism: New functions and therapeutic approaches in cancer DOI
Huanji Xu,

Sheng Zhou,

Qiulin Tang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2020, Volume and Issue: 1874(1), P. 188394 - 188394

Published: July 19, 2020

Language: Английский

Citations

276
Metabolic programming and immune suppression in the tumor microenvironment DOI Creative Commons
Emily N. Arner, Jeffrey C. Rathmell

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 421 - 433

Published: Feb. 16, 2023

Language: Английский

Citations

265
Metabolic signaling in T cells DOI Creative Commons
Justin A. Shyer, Richard A. Flavell, Will Bailis

et al.

Cell Research, Journal Year: 2020, Volume and Issue: 30(8), P. 649 - 659

Published: July 24, 2020

Abstract The maintenance of organismal homeostasis requires partitioning and transport biochemical molecules between organ systems, their composite cells, subcellular organelles. Although transcriptional programming undeniably defines the functional state cells tissues, underlying networks are intricately intertwined with transcriptional, translational, post-translational regulation. Studies metabolic regulation immunity have elegantly illustrated this phenomenon. immune system interface a diverse set environmental conditions. Circulating perfuse peripheral organs in blood lymph, patrolling for pathogen invasion. Resident remain tissues play more newly appreciated roles tissue immunity. Each these cell populations interacts unique dynamic environments, which vary greatly composition. Furthermore, effector response to activating cues cellular adaptations supply requisite landscape. In review, we examine role spatial processes function. We focus on studies lymphocyte metabolism, reference greater immunometabolism literature when appropriate illustrate concept.

Language: Английский

Citations

262
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics DOI Creative Commons
Yajun Duan, Ke Gong, Suowen Xu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Aug. 2, 2022

Abstract Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD), neurodegenerative and cancers, particularly CVD which accumulation lipids (mainly cholesteryl esters) within macrophage/foam cells underneath endothelial layer drives formation atherosclerotic lesions eventually. More more studies have shown that lowering level, especially low-density lipoprotein protects system prevents events effectively. Maintaining is determined by biosynthesis, uptake, efflux, transport, storage, utilization, and/or excretion. All processes should be precisely controlled regulatory pathways. Based on regulation homeostasis, many interventions been developed to lower inhibiting biosynthesis uptake or enhancing utilization Herein, we summarize historical review research events, current understandings molecular pathways playing key regulating cholesterol-lowering clinics preclinical well new targets their clinical advances. importantly, discuss benefits those for treatment including obesity, diabetes, nonalcoholic fatty liver disease, cancer, osteoporosis virus infection.

Language: Английский

Citations

243
Obesity, Type 2 Diabetes, and Cancer Risk DOI Creative Commons

Tiffany Scully,

Abora Ettela,

Derek LeRoith

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 10

Published: Feb. 2, 2021

Obesity and type 2 diabetes have both been associated with increased cancer risk are becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance dyslipidemia obesity implicated in the obesity-cancer relationship. Multiple mechanisms proposed to link progression, including an increase insulin/IGF-1 signaling, lipid glucose uptake metabolism, alterations profile of cytokines, chemokines, adipokines, well changes adipose tissue directly adjacent sites. This review aims summarize provide update on epidemiological mechanistic evidence linking cancer, focusing roles insulin, lipids, tissue.

Language: Английский

Citations

164
Bacteria in cancer initiation, promotion and progression DOI
Geniver El Tekle, Wendy S. Garrett

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(9), P. 600 - 618

Published: July 3, 2023

Language: Английский

Citations

156
Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy DOI
Shan Wang, Jialei Fu, Huifeng Hao

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 170, P. 105728 - 105728

Published: June 11, 2021

Language: Английский

Citations

138
Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety Profile DOI Creative Commons
Lei Zhang,

Feng-Jun He,

Lina Gao

et al.

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 1575 - 1586

Published: Feb. 1, 2021

Background: Exosomes are a type of membrane vesicles secreted by living cells. Recent studies suggest exosome-like nanovesicles (ELNVs) from fruits and vegetables involved in tissue renewal process functional regulation against inflammatory diseases or cancers. However, there few reports on ELNVs derived medicinal plants. Methods: Asparagus cochinchinensis (Lour.) Merr. (ACNVs) were isolated characterized. Cytotoxicity, antiproliferative apoptosis-inducing capacity ACNVs hepatoma carcinoma cell assessed. The endocytosis mechanism was evaluated Hep G2 cells the presence different inhibitors. In vivo distribution detected healthy tumor-bearing mice after scavenger receptors (SRs) blockade. PEG engineering achieved through optimizing pharmacokinetic profiles. antitumor activity toxicity xenograft model. Results: purified using differential centrifugation method accompanied sucrose gradient ultracentrifugation. optimized had an average size about 119 nm showed typical cup-shaped nanostructure containing lipids, proteins, RNAs. found to possess specific proliferation associated with pathway. could be internalized into tumor mainly via phagocytosis, but they quickly cleared once entering blood. Blocking SRs PEGylation decoration prolonged blood circulation time increased accumulation sites. results that PEGylated significantly inhibit growth without side effects. Conclusion: This study provides promising nano platform edible can used therapy negligible Keywords: exosome, nanovesicles, ,

Language: Английский

Citations

126
Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment DOI Creative Commons
Guofeng Ma, Zhilei Zhang, Peng Li

et al.

Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 20(1)

Published: July 27, 2022

Abstract Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that glutamine metabolism is putative determinant the anti-tumor response tumor microenvironment (TME). Usually, predatory uptake by cells TME results limited utilization affects response. The cell-programmed partitioning also However, tumors modulates regulating PD-L1 expression. Likewise, their function. Additionally, different types inhibitors extensively regulate while suppressing cell proliferation. Herein, we discuss how metabolic regulates responses, as well functional changes context targeting metabolism, which can better explain potential combination with immunotherapy for cancer.

Language: Английский

Citations

117