Environmental Health Perspectives,
Journal Year:
2021,
Volume and Issue:
129(5)
Published: May 1, 2021
Background:
The
epidemiological
literature
of
associations
between
atmospheric
pollutant
exposure
and
breast
cancer
incidence
has
recently
strongly
evolved.
Objectives:
We
aimed
to
perform
a)
a
meta-analysis
studies
considering
this
relationship,
correcting
for
publication
bias
taking
menopausal
status
hormone
responsiveness
into
account;
b)
the
pollutants
most
likely
affect
cancer,
an
assessment
corresponding
number
attributable
cases
in
France
related
economic
costs.
Methods:
conducted
review
random-effects
meta-analyses
examining
association
fine
particulate
matter
with
aerodynamic
diameter
less
than
or
equal
2.5μm
(PM2.5),
10
μm
(PM10),
NO2
long-term
incidence;
additional
analyses
were
stratified
on
tumor
status.
resulting
dose–response
functions
combined
modeled
exposures
2013
France,
treatments
costs,
lost
productivity,
years
life
lost,
estimate
cancers
pollution
costs
France.
Results:
identified
32,
27,
36
effect
estimates
PM2.5,
PM10,
NO2,
respectively.
meta-analytical
relative
risk
corrected
1.006
[95%
confidence
interval
(CI):
0.941,
1.076],
1.047
(95%
CI:
0.984,
1.113),
1.023
1.005,
1.041),
estimated
effects
appeared
higher
premenopausal
postmenopausal
women
responsive
positive
(ER+/PR+)
negative
(ER–/PR–)
cancers.
Assuming
causal
we
that
1,677
374,
2,914)
new
annually
3.15%
0.70,
5.48)
incident
cases.
tangible
intangible
be
€825
million
(low,
high:
570,
1,080)
per
year.
Conclusion:
These
findings
suggest
decreasing
correlated
air
could
lower
risk.
https://doi.org/10.1289/EHP8419
ACS Earth and Space Chemistry,
Journal Year:
2021,
Volume and Issue:
5(4), P. 722 - 748
Published: April 5, 2021
Emitted
by
numerous
primary
sources
and
formed
secondary
sources,
atmospheric
brown
carbon
(BrC)
aerosol
is
chemically
complex.
As
BrC
ages
in
the
atmosphere
via
a
variety
of
chemical
physical
processes,
its
composition
optical
properties
change
significantly,
altering
impacts
on
climate.
Research
past
decade
has
considerably
expanded
our
understanding
reactions
both
gas
condensed
phases.
We
review
these
recent
advances
aging
chemistry
with
focus
phase
leading
to
formation,
aqueous
in-cloud
particle
reactions.
Connections
are
made
between
single
component
proxies
more
complex
mixtures
as
well
laboratory
field
measurements
chemistry.
General
conclusions
that
can
darken
particles
over
short
time
scales
hours
close
source
considerable
photobleaching
oxidative
whitening
will
occur
when
day
or
removed
from
source.
New England Journal of Medicine,
Journal Year:
2021,
Volume and Issue:
385(20), P. 1881 - 1892
Published: Nov. 10, 2021
ardiovascular
diseases
are
the
world's
leading
cause
of
disability
and
death.Such
were
responsible
in
2019
for
an
estimated
18.6
million
deaths
globally
957,000
United
States.
1,2reat
gains
have
been
made
reducing
incidence
cardiovascular
disease
related
mortality
high-income
countries.Identification
risk
factors
such
as
tobacco
use,
hypertension,
dyslipidemia,
physical
inactivity,
diabetes
large,
prospective,
multiyear
epidemiologic
studies
has
key.Recognition
these
increased
awareness
diseases,
enhanced
early
detection,
guided
treatment
prevention.These
advances
contributed
to
more
than
a
50%
decline
from
States
since
1950.
3ollution
-unwanted
material
released
into
environment
by
human
activity
-is
another
important
yet
often
overlooked
factor
(Fig.
1).
4
The
Global
Burden
Disease
(GBD)
study
estimates
that
pollution
was
9
worldwide
2019,
61.9%
which
due
disease,
including
ischemic
heart
(31.7%)
stroke
(27.7%)
2A).
1
These
numbers,
large
they
are,
almost
certainly
undercount
full
contribution
global
burden
because
based
on
only
subset
environmental
factors.
4ntil
now,
reduction
received
scant
attention
programs
control
largely
absent
guidelines
regarding
prevention
focused
exclusively
individual
behavioral
metabolic
5This
is
omission,
incorporation
could
save
millions
lives.In
this
review,
we
summarize
current
evidence
linking
suggest
evidence-based
strategies
prevention.We
discuss
exposure
persons
but
argue
lasting
pollution-related
can
be
achieved
through
government-supported
interventions
societal
scale
at
its
source
encourage
rapid
transition
clean
energy.We
note
actions
will
also
slow
pace
climate
change
thus
produce
double
benefit.Only
multipronged
strategy
combines
with
epidemic
contained.
A
ir
Pollu
tionAir
complex
mixture
varies
concentration
composition
according
time
place
greatly
influenced
weather.
5,6It
includes
particulate
gaseous
primary
pollutants
nitrogen
oxides
(NO
x
),
sulfur
dioxide,
carbon
monoxide,
directly
atmosphere,
Cardiovascular Research,
Journal Year:
2021,
Volume and Issue:
118(14), P. 2880 - 2902
Published: Sept. 30, 2021
Abstract
Non-communicable
diseases
(NCDs)
are
fatal
for
more
than
38
million
people
each
year
and
thus
the
main
contributors
to
global
burden
of
disease
accounting
70%
mortality.
The
majority
these
deaths
caused
by
cardiovascular
(CVD).
risk
NCDs
is
strongly
associated
with
exposure
environmental
stressors
such
as
pollutants
in
air,
noise
exposure,
artificial
light
at
night,
climate
change,
including
heat
extremes,
desert
storms,
wildfires.
In
addition
traditional
factors
CVD
diabetes,
arterial
hypertension,
smoking,
hypercholesterolaemia,
genetic
predisposition,
there
a
growing
body
evidence
showing
that
physicochemical
environment
contribute
significantly
high
NCD
numbers.
Furthermore,
urbanization
accumulation
intensification
stressors.
This
comprehensive
expert
review
will
summarize
epidemiology
pathophysiology
focus
on
NCDs.
We
also
discuss
solutions
mitigation
measures
lower
impact
CVD.
Environment International,
Journal Year:
2021,
Volume and Issue:
159, P. 107020 - 107020
Published: Dec. 8, 2021
Chronic
exposure
to
fine
particulate
matter
(PM2.5)
poses
a
major
global
health
risk,
commonly
assessed
by
assuming
equivalent
toxicity
for
different
PM2.5
constituents.
We
used
data-informed
atmospheric
model
and
recent
exposure–response
functions
calculate
the
burden
of
ambient
from
ten
source
categories.
estimate
4.23
(95%
confidence
interval
3.0–6.14)
million
excess
deaths
annually
PM2.5.
distinguished
contributions
sources
black
carbon
(BC),
primary
organic
aerosols
(POA)
anthropogenic
secondary
(aSOA).
These
components
make
up
∼20%
total
in
South
East
Asia
Africa.
find
that
domestic
energy
use
burning
solid
biofuels
is
largest
contributor
BC,
POA
aSOA
globally.
Epidemiological
toxicological
studies
indicate
these
compounds
may
be
relatively
more
hazardous
than
other
such
as
soluble
salts,
related
their
high
potential
inflict
oxidative
stress.
performed
sensitivity
analyses
considering
species
harmful
compared
PM2.5,
suggested
using
range
relative
risks.
show
emerges
leading
cause
mortality
attributable
notably
acknowledge
uncertainties
inherent
our
assumed
enhanced
BC
aerosol
components,
which
suggest
need
better
understand
mechanisms
magnitude
associated
risks
consequences
regulatory
policies.
However
assessment
importance
emissions
premature
robust
assumptions
about
risk.
Environment International,
Journal Year:
2022,
Volume and Issue:
166, P. 107325 - 107325
Published: May 31, 2022
Organic
aerosol
(OA)
is
a
key
component
of
total
submicron
particulate
matter
(PM1),
and
comprehensive
knowledge
OA
sources
across
Europe
crucial
to
mitigate
PM1
levels.
has
well-established
air
quality
research
infrastructure
from
which
yearlong
datasets
using
21
chemical
speciation
monitors
(ACSMs)
1
mass
spectrometer
(AMS)
were
gathered
during
2013-2019.
It
includes
9
non-urban
13
urban
sites.
This
study
developed
state-of-the-art
source
apportionment
protocol
analyse
long-term
spectrum
data
by
applying
the
most
advanced
strategies
(i.e.,
rolling
PMF,
ME-2,
bootstrap).
harmonised
was
followed
strictly
for
all
22
datasets,
making
results
more
comparable.
In
addition,
it
enables
quantification
common
components
such
as
hydrocarbon-like
(HOA),
biomass
burning
(BBOA),
cooking-like
(COA),
oxidised-oxygenated
(MO-OOA),
less
(LO-OOA).
Other
coal
combustion
(CCOA),
solid
fuel
(SFOA:
mainly
mixture
peat
combustion),
cigarette
smoke
(CSOA),
sea
salt
(mostly
inorganic
but
part
spectrum),
coffee
OA,
ship
industry
could
also
be
separated
at
few
specific
Oxygenated
(OOA)
make
up
(average
=
71.1%,
range
43.7
100%).
Solid
combustion-related
BBOA,
CCOA,
SFOA)
are
still
considerable
with
in
16.0%
yearly
contribution
yet
winter
months
(21.4%).
Overall,
this
works
effectively
sites
governed
different
generates
robust
consistent
results.
Our
work
presents
overview
unique
combination
high
time
resolution
(30-240
min)
coverage
(9-36
months),
providing
essential
information
improve/validate
quality,
health
impact,
climate
models.
Proceedings of the National Academy of Sciences,
Journal Year:
2022,
Volume and Issue:
119(26)
Published: June 22, 2022
There
are
still
significant
knowledge
gaps
in
understanding
the
intrusion
and
retention
of
exogeneous
particles
into
central
nervous
system
(CNS).
Here,
we
uncovered
various
fine
human
cerebrospinal
fluids
(CSFs)
identified
ambient
environmental
or
occupational
exposure
sources
these
particles,
including
commonly
found
(e.g.,
Fe-
Ca-containing
ones)
other
compositions
that
have
not
been
reported
previously
(such
as
malayaite
anatase
TiO
2
),
by
mapping
their
chemical
structural
fingerprints.
Furthermore,
using
mouse
vitro
models,
unveiled
a
possible
translocation
pathway
inhaled
from
lung
to
brain
through
blood
circulation
(via
dedicated
biodistribution
mechanistic
studies).
Importantly,
with
aid
isotope
labeling,
obtained
kinetics
mice,
indicating
much
slower
clearance
rate
localized
exogenous
than
main
metabolic
organs.
Collectively,
our
results
provide
piece
evidence
on
CNS
support
association
between
inhalation
transport
tissues.
This
work
thus
provides
additional
insights
for
continued
investigation
adverse
effects
air
pollution
brain.
Nature Energy,
Journal Year:
2022,
Volume and Issue:
7(2), P. 194 - 202
Published: Jan. 6, 2022
Abstract
The
combustion
of
solid
fuels,
including
coal
and
biomass,
is
a
main
anthropogenic
source
atmospheric
particulate
matter
(PM).
hidden
costs
have
been
underestimated
due
to
lack
consideration
the
toxicity
PM.
Here
we
report
unequal
inhalable
PM
emitted
from
energy
use
in
residential
sector
coal-fired
power
plants
(CFPPs).
incomplete
burning
fuels
household
stoves
generates
much
higher
concentrations
carbonaceous
matter,
resulting
more
than
one
order
magnitude
greater
that
CFPPs.
When
compared
with
CFPPs,
consumed
only
tenth
mainland
China
2017,
but
it
contributed
about
200-fold
population-weighted
toxic
potency-adjusted
2.5
exposure
risk.
We
suggest
-related
should
be
considered
when
making
air
pollution
emission
control
strategies,
sources
receive
policy
attention
reduce
risks.
Environmental Science & Technology Letters,
Journal Year:
2022,
Volume and Issue:
9(6), P. 501 - 506
Published: June 6, 2022
The
World
Health
Organization
recently
updated
their
air
quality
guideline
for
annual
fine
particulate
matter
(PM2.5)
exposure
from
10
to
5
μg
m-3,
citing
global
health
considerations.
We
explore
if
this
is
attainable
across
different
regions
of
the
world
using
a
series
model
sensitivity
simulations
2019.
Our
results
indicate
that
>90%
population
exposed
PM2.5
concentrations
exceed
m-3
and
only
few
sparsely
populated
(largely
in
boreal
North
America
Asia)
experience
average
<5
m-3.
find
even
under
an
extreme
abatement
scenario,
with
no
anthropogenic
emissions,
more
than
half
world's
would
still
exposures
above
(including
>70%
>60%
African
Asian
populations,
respectively),
largely
due
fires
natural
dust.
demonstrate
large
heterogeneity
composition
highlight
how
sensitive
reductions
emissions.
thus
suggest
use
speciated
aerosol
guidelines
help
facilitate
region-specific
management
decisions
improve
health-burden
estimates
exposure.