Incident dementia and long-term exposure to constituents of fine particle air pollution: A national cohort study in the United States

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 120(1)

Published: Dec. 27, 2022

Growing evidence suggests that fine particulate matter (PM

Language: Английский

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A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 2(4), P. 195 - 207

Published: Aug. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Language: Английский

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Toxicity and health effects of ultrafine particles: Towards an understanding of the relative impacts of different transport modes

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116186 - 116186

Published: May 22, 2023

Exposure to particulate matter (PM) has been associated with a wide range of adverse health effects, but it is still unclear how particles from various transport modes differ in terms toxicity and associations different human outcomes. This literature review aims summarize toxicological epidemiological studies the effect ultrafine (UFPs), also called nanoparticles (NPs, <100 nm), focus on vehicle exhaust (particularly comparing diesel biodiesel) non-exhaust as well shipping (harbor), aviation (airport) rail (mainly subway/underground). The includes both collected laboratory tests field (intense traffic environments or close harbor, airport, subway). In addition, UFPs are reviewed special attention aimed at distinguishing effects modes. Results indicate that fossil biodiesel NPs show toxic effects. Several vivo inhalation not only impacts lung, triggers cardiovascular negative brain, although few compared sources. Few were found NPs, available results suggest similar traffic-related particles. There little data related linked several sources (shipping, road tire wear, subway NPs), vitro highlighted role metals brake wear Finally, emphasized current limited knowledge source-specific discusses necessity future research for better understanding relative potencies their use risk assessment.

Language: Английский

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Micro(nano)plastics in the Human Body: Sources, Occurrences, Fates, and Health Risks

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 5, 2024

The increasing global attention on micro(nano)plastics (MNPs) is a result of their ubiquity in the water, air, soil, and biosphere, exposing humans to MNPs daily basis threatening human health. However, crucial data body, including sources, occurrences, behaviors, health risks, are limited, which greatly impedes any systematic assessment impact body. To further understand effects we must identify existing knowledge gaps that need be immediately addressed provide potential solutions these issues. Herein, examined current literature behaviors body as well risks. Furthermore, identified key resolved comprehensively assess Additionally, complexity lack efficient analytical methods main barriers impeding investigations necessitating development standard unified method. Finally, highlighted for interdisciplinary studies from environmental, biological, medical, chemical, computer, material scientists fill drive research. Considering inevitability occurrence exposure MNPs, more urgently required enhance our understanding negative

Language: Английский

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The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(6), P. 101581 - 101581

Published: May 22, 2024

Non-communicable diseases (NCD) constitute one of the highest burdens disease globally and are associated with inflammatory responses in target organs. There is increasing evidence significant human exposure to micro- nanoplastics (MnPs). This review environmental MnP health impacts indicates that particles, directly indirectly through their leachates, may exacerbate inflammation. Meanwhile, persistent inflammation NCDs gastrointestinal respiratory systems potentially increases uptake, thus influencing access distal Consequently, a future increase augments risk severity NCDs. critical need for an integrated one-health approach research assessing drivers bidirectional links Assessing these risks requires interdisciplinary efforts identify link organismal uptake studies impacted mechanisms outcomes.

Language: Английский

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Interfacing with the Brain: How Nanotechnology Can Contribute

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Interfacing artificial devices with the human brain is central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along technology. Mechanical levers cable winches were used to move parts during mechanical age. Sophisticated electronic wiring remote control arisen age, ultimately leading plug-and-play computer interfaces. Nonetheless, brains so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, most technology mechanically and/or electrically engineered, whereas a living, dynamic entity. As result, worlds difficult interface one another. Nanotechnology, which encompasses engineered solid-state objects integrated circuits, excels at small length scales single few hundred nanometers and, thus, matches sizes biomolecules, biomolecular assemblies, cells. Consequently, we envision nanomaterials nanotools as opportunities in alternative ways. Here, review existing literature on use nanotechnology look forward discussing perspectives limitations based authors' expertise across range complementary disciplines─from neuroscience, engineering, physics, chemistry biology medicine, science mathematics, social jurisprudence. We focus but also include information from related fields when useful complementary.

Language: Английский

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Prediction of Monthly PM2.5 Concentration in Liaocheng in China Employing Artificial Neural Network

Atmosphere, Journal Year: 2022, Volume and Issue: 13(8), P. 1221 - 1221

Published: Aug. 2, 2022

Fine particulate matter (PM2.5) affects climate change and human health. Therefore, the prediction of PM2.5 level is particularly important for regulatory planning. The main objective study to predict concentration employing an artificial neural network (ANN). annual in Liaocheng from 2014 2021 shows a gradual decreasing trend. air quality during lockdown after periods 2020 was obviously improved compared with same 2019. ANN employed contains hidden layer 6 neurons, input 11 parameters, output layer. First, used 80% data training, then 10% verification. value correlation coefficient (R) training validation 0.9472 0.9834, respectively. In forecast period, it demonstrated that model Bayesian regularization (BR) algorithm (trainbr) obtained best forecasting performance terms R (0.9570), mean absolute error (4.6 μg/m3), root square (6.6 has produced accurate results. These results prove effective monthly predicting due fact can identify nonlinear relationships between variables.

Language: Английский

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Concomitant exposure to air pollution, green space, and noise and risk of stroke: a cohort study from Denmark

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 31, P. 100655 - 100655

Published: May 26, 2023

Air pollution, road traffic noise, and green space are correlated factors, associated with risk of stroke. We investigated their independent relationship stroke in multi-exposure analyses estimated cumulative burden.For all persons, ≥50 years age living Denmark from 2005 to 2017, we established complete address histories running 5-year mean exposure fine particles (PM2.5), ultrafine particles, elemental carbon, nitrogen dioxide (NO2), noise at the most, least exposed façade. For air pollutants, total, non-traffic contributions. Green around residence was land use maps. Hazard ratios (HR) 95% confidence limits (CL) were Cox proportional hazards models used calculate indices (CRI). adjusted for individual sociodemographic covariates available our dataset (which did not include information about life styles medical conditions).The cohort accumulated 18,344,976 follow-up 94,256 cases All exposures single pollutant models. In multi-pollutant analyses, only PM2.5 (HR: 1.058, CI: 1.040-1.075) most façade 1.033, 1.024-1.042) independently a higher Both pollution contributed substantially CRI (1.103, 1.092-1.114) model space, total concentrations.Environmental both stroke.Health Effects Institute (HEI) (Assistance Award No. R-82811201).

Language: Английский

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Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders

Human & Experimental Toxicology, Journal Year: 2023, Volume and Issue: 42

Published: March 1, 2023

Recent extensive evidence suggests that ambient fine particulate matter (PM2.5, with an aerodynamic diameter ≤2.5 μm) may be neurotoxic to the brain and cause central nervous system damage, contributing neurodevelopmental disorders, such as autism spectrum neurodegenerative diseases, Alzheimer's disease Parkinson's disease, mental schizophrenia, depression, bipolar disorder. PM2.5 can enter via various pathways, including blood-brain barrier, olfactory system, gut-brain axis, leading adverse effects on CNS. Studies in humans animals have revealed PM2.5-mediated mechanisms, neuroinflammation, oxidative stress, systemic inflammation, gut flora dysbiosis, play a crucial role CNS damage. Additionally, exposure induce epigenetic alterations, hypomethylation of DNA, which contribute pathogenesis some Through literature analysis, we suggest promising therapeutic targets for alleviating PM2.5-induced neurological damage include inhibiting microglia overactivation, regulating microbiota antibiotics, targeting signaling PKA/CREB/BDNF WNT/β-catenin. several studies observed association between changes neuropsychiatric disorders. This review summarizes discusses possible mechanisms by causes neurotoxicity.

Language: Английский

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Ambient air pollution and infant health: a narrative review

EBioMedicine, Journal Year: 2023, Volume and Issue: 93, P. 104609 - 104609

Published: May 9, 2023

The extensive evidence regarding the effects of ambient air pollution on child health is well documented, but limited review summarized their during infancy. Symptoms or conditions attributed to in infancy could result progression severe diseases childhood. Here, we reviewed previous empirical epidemiological studies and/or reviews for evaluating linkages between and various infant outcomes including adverse birth outcomes, morbidity mortality, early respiratory health, allergic symptoms, neurodevelopment, growth other relevant outcomes. Patterns associations varied by different pollutants (i.e., particles gaseous pollutants), exposure periods pregnancy postpartum) lengths long-term short-term). Protection requires that paediatricians, researchers, policy makers understand what extent infants are affected pollution, a call action still necessary reduce pollution.

Language: Английский

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