BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance DOI
Audrey Lee, Katharine Floyd, Shengyang Wu

et al.

Nature Immunology, Journal Year: 2023, Volume and Issue: 25(1), P. 41 - 53

Published: Nov. 30, 2023

Language: Английский

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern DOI Creative Commons
Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis

et al.

Science, Journal Year: 2021, Volume and Issue: 374(6572)

Published: Oct. 15, 2021

Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding longevity vaccine-induced immune protection. Goel et al . examined B T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study never had infection compared with people recovered from SARS-CoV-2. Humoral cellular was observed vaccinated individuals, as were functional Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) variants. Analysis cell activity suggested that robust may prevent hospitalization by limiting development disease. —PNK

Language: Английский

Citations

804
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses DOI Creative Commons
Mohamad‐Gabriel Alameh, István Tombácz, Emily Bettini

et al.

Immunity, Journal Year: 2021, Volume and Issue: 54(12), P. 2877 - 2892.e7

Published: Nov. 4, 2021

Language: Английский

Citations

459
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination DOI Creative Commons
Katharina Röltgen, Sandra C. A. Nielsen, Oscar Silva

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(6), P. 1025 - 1040.e14

Published: Jan. 25, 2022

During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated infection or adenoviral (ChAdOx1-S Gam-COVID-Vac) inactivated viral (BBIBP-CorV) vaccines. analyzed human lymph nodes after for correlates of serological differences. Antibody breadth against variants is lower compared with all vaccines evaluated but improves over several months. Viral variant elicits variant-specific antibodies, prior imprints responses toward Wuhan-Hu-1 rather than antigens. In contrast to disrupted germinal centers (GCs) in during infection, stimulates robust GCs containing spike antigen up 8 weeks postvaccination some cases. antibody specificity, breadth, maturation are affected imprinting exposure history distinct histological antigenic contexts vaccination.

Language: Английский

Citations

383
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine DOI Open Access
Chunfeng Li, Audrey Lee, Lilit Grigoryan

et al.

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(4), P. 543 - 555

Published: March 14, 2022

Language: Английский

Citations

335
Innate immune mechanisms of mRNA vaccines DOI Creative Commons
R Verbeke, Michael J. Hogan, Karin Loré

et al.

Immunity, Journal Year: 2022, Volume and Issue: 55(11), P. 1993 - 2005

Published: Nov. 1, 2022

Language: Английский

Citations

230
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype DOI Creative Commons
Gisella Guerrera, Mario Picozza, Silvia D’Orso

et al.

Science Immunology, Journal Year: 2021, Volume and Issue: 6(66)

Published: Nov. 2, 2021

SARS-CoV-2 mRNA vaccination induces stem cell memory T cells specific for the virus that persist up to 6 months.

Language: Английский

Citations

206
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis DOI
Ioannis P. Trougakos, Evangelos Terpos, Harry Alexopoulos

et al.

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(7), P. 542 - 554

Published: April 21, 2022

Language: Английский

Citations

200
Impact of the Human Cell Atlas on medicine DOI Open Access
Jennifer Rood, Aidan Maartens,

Anna Hupalowska

et al.

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(12), P. 2486 - 2496

Published: Dec. 1, 2022

Language: Английский

Citations

145
Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study DOI
Sara Y. Tartof, Jeff Slezak, Laura Puzniak

et al.

The Lancet Respiratory Medicine, Journal Year: 2022, Volume and Issue: 10(7), P. 689 - 699

Published: April 22, 2022

Language: Английский

Citations

134
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants DOI Creative Commons
Catherine J. Reynolds, Joseph M. Gibbons, Corinna Pade

et al.

Science, Journal Year: 2022, Volume and Issue: 375(6577), P. 183 - 192

Published: Jan. 14, 2022

Immune imprinting For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune responses to heterologous variants are influenced by a person’s infection history. Healthcare workers (HCWs) may be exposed several doses and types of antigens, either natural or vaccination. Reynolds et al . studied cohort UK HCWs followed since March 2020. The immunological profiles these people depended on how often the subject had encountered antigen which variant was involved. Vaccine after were found less effective if involved spike from virus. Unfortunately, N501Y mutation, in many variants, seems induce regulatory T cell transcription factor FOXP3, indicating that virus could subvert function. Changes antibody binding between also means serology data using Wuhan Hu-1 S1 receptor-binding domain sequence not reliable measure protection. —CA

Language: Английский

Citations

121