Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder DOI Creative Commons
Samantha J. Tener,

Zhi Lin,

Scarlet J. Park

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 17, 2024

Abstract Mutations in Cullin-3 ( Cul3 ), a conserved gene encoding ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we characterize ASD-related pathologies caused by neuron-specific knockdown Drosophila . We confirmed that neuronal causes short sleep, paralleling sleep disturbances ASD. Because defects and ASD linked to metabolic dysregulation, tested the starvation response of flies; they starved faster had lower triacylglyceride levels than controls, suggesting homeostasis. is also characterized increased biomarkers oxidative stress; found sensitivity hyperoxia, an exogenous stress. Additional hallmarks deficits social interactions learning. Using courtship suppression assay measures memory prior courtship, reduced learning compared controls. Finally, depletion alters anatomy mushroom body, brain region required for sleep. Taken together, phenotypes flies establish these as genetic model study molecular cellular mechanisms underlying pathology, including stress dysregulation neurodevelopment.

Language: Английский

A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1 DOI Creative Commons
Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1371 - 1393.e7

Published: May 7, 2024

The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen prevents NASH development as well ameliorates established fibrosis without affecting total calorie intake. Furthermore, the blunted NASH-HCC when applied therapeutically. timing, length, number cycles type diet were critical parameters determining benefits fasting. Combined proteome, transcriptome, metabolome analyses peroxisome-proliferator-activated receptor alpha (PPARα) glucocorticoid-signaling-induced PCK1 act co-operatively hepatic executors response. In line with this, PPARα targets reduced human NASH. Notably, only initiated during active phase mice robustly induced glucocorticoid signaling free-fatty-acid-induced signaling. However, hepatocyte-specific deletion partially abrogated contrast, combined knockdown Ppara Pck1 vivo abolished beneficial outcomes against inflammation fibrosis. Moreover, overexpression alone or together lowered triglycerides steatosis. Our data support notion is a promising intervention subsequent liver cancer.

Language: Английский

Citations

30
Interorgan rhythmicity as a feature of healthful metabolism DOI
Joseph Bass

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(4), P. 655 - 669

Published: Feb. 8, 2024

Language: Английский

Citations

20
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies DOI Open Access
Justyna Godos, Walter Currenti, Raffaele Ferri

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 529 - 529

Published: Jan. 31, 2025

Fasting-feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal underscores importance maintaining alignment order to avoid creating metabolic environment conducive carcinogenesis following molecular systemic disruption performance immune function. chronicity such condition may support initiation progression cancer through variety mechanisms, including increased oxidative stress, suppression, activation proliferative signaling pathways. This review aims summarize current evidence from human studies provide an overview potential mechanisms underscoring role chrononutrition (including time-restricted eating) on risk. Current shows that morning chronotype, suggesting physiological rhythms eating timing, associated with lower risk cancer. Also, early prolonged nighttime fasting were also suggests chronotype influences cell cycle regulation, modulation pathways inflammation, gut microbiota fluctuations. In conclusion, although there are no clear guidelines this matter, emerging supports hypothesis time-related (i.e., time/calorie-restricted feeding intermittent/periodic fasting) could potentially lead reduced

Language: Английский

Citations

3
Circadian clock communication during homeostasis and ageing DOI
Thomas Mortimer, Jacob G. Smith, Pura Muñoz‐Cánoves

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

2
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation DOI Creative Commons
J. Yuyang Lu, Matthew Simon, Yang Zhao

et al.

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(6), P. 836 - 856.e5

Published: May 16, 2022

Language: Английский

Citations

58
Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial DOI Creative Commons

Mingqian He,

Jingya Wang, Qian Liang

et al.

Cell Reports Medicine, Journal Year: 2022, Volume and Issue: 3(10), P. 100777 - 100777

Published: Oct. 1, 2022

Overconsumption of carbohydrate-rich food combined with adverse eating patterns contributes to the increasing incidence metabolic syndrome (MetS) in China. Therefore, we conducted a randomized trial determine effects low-carbohydrate diet (LCD), an 8-h time-restricted (TRE) schedule, and their combination on body weight abdominal fat area (i.e., primary outcomes) cardiometabolic outcomes participants MetS. Compared baseline, all 3-month treatments significantly reduce subcutaneous area, but only TRE treatment visceral (VFA), fasting blood glucose, uric acid (UA), dyslipidemia. Furthermore, compared changes LCD, further decrease VFA, while yields more benefits glycemic control, UA, In conclusion, without change physical activity, or LCD can serve as effective for MetS (ClinicalTrials.gov: NCT04475822).

Language: Английский

Citations

53
The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function DOI
Yihang Zhao, Mengzhen Jia, Weixuan Chen

et al.

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 182, P. 206 - 218

Published: Feb. 24, 2022

Language: Английский

Citations

48
Intermittent fasting protects against Alzheimer’s disease in mice by altering metabolism through remodeling of the gut microbiota DOI
Rui‐Yuan Pan, Jing Zhang, Jinlei Wang

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 2(11), P. 1024 - 1039

Published: Nov. 17, 2022

Language: Английский

Citations

48
Complex physiology and clinical implications of time-restricted eating DOI
Max C. Petersen,

Molly R. Gallop,

Stephany Flores Ramos

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 102(4), P. 1991 - 2034

Published: July 14, 2022

Time-restricted eating (TRE) is a dietary intervention that limits food consumption to specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects important interactions among eating, circadian biology, metabolic homeostasis. In contrast, it difficult make firm conclusions regarding the people because heterogeneity results, regimens, study populations. this review, we 1) provide background history meal normal physiology fasting; 2) discuss interaction between molecular metabolism TRE; 3) integrate results preclinical clinical studies evaluated functions; 4) summarize other time-related interventions people; identify current gaps knowledge framework for future research directions.

Language: Английский

Citations

42
Fasting: From Physiology to Pathology DOI Creative Commons
Dongmei Tang,

Qiuyan Tang,

Wei Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Feb. 3, 2023

Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.

Language: Английский

Citations

39