Attractor and integrator networks in the brain

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(12), P. 744 - 766

Published: Nov. 3, 2022

Language: Английский

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A unifying perspective on neural manifolds and circuits for cognition

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(6), P. 363 - 377

Published: April 13, 2023

Language: Английский

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Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster

Cell, Journal Year: 2024, Volume and Issue: 187(10), P. 2574 - 2594.e23

Published: May 1, 2024

High-resolution electron microscopy of nervous systems has enabled the reconstruction synaptic connectomes. However, we do not know sign for each connection (i.e., whether a is excitatory or inhibitory), which implied by released transmitter. We demonstrate that artificial neural networks can predict transmitter types presynapses from micrographs: network trained to six transmitters (acetylcholine, glutamate, GABA, serotonin, dopamine, octopamine) achieves an accuracy 87% individual synapses, 94% neurons, and 91% known cell across D. melanogaster whole brain. visualize ultrastructural features used prediction, discovering subtle but significant differences between phenotypes. also analyze distributions brain find neurons develop together largely express only one fast-acting GABA). hope our publicly available predictions act as accelerant neuroscientific hypothesis generation fly.

Language: Английский

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Transforming representations of movement from body- to world-centric space

Nature, Journal Year: 2021, Volume and Issue: 601(7891), P. 98 - 104

Published: Dec. 15, 2021

Language: Английский

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A neural circuit for wind-guided olfactory navigation

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 8, 2022

Abstract To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction location. Where and how these two are integrated to support navigation is unclear. Here we describe pathway the Drosophila fan-shaped body that encodes attractive promotes upwind navigation. We show neurons throughout this encode odor, but not direction. Using connectomics, identify local called h∆C receive input from previously described pathway. exhibit odor-gated, direction-tuned activity, sparse activation of in reproducible direction, activity required for persistent orientation during odor. Based on connectome data, develop computational model showing can promote goal such as an source. Our results suggest processed by separate pathways within goal-directed

Language: Английский

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Neural dynamics and architecture of the heading direction circuit in zebrafish

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(5), P. 765 - 773

Published: April 24, 2023

Abstract Animals generate neural representations of their heading direction. Notably, in insects, direction is topographically represented by the activity neurons central complex. Although head cells have been found vertebrates, connectivity that endows them with properties unknown. Using volumetric lightsheet imaging, we find a topographical representation neuronal network zebrafish anterior hindbrain, where sinusoidal bump rotates following directional swims fish and otherwise stable over many seconds. Electron microscopy reconstructions show that, although cell bodies are located dorsal region, these arborize interpeduncular nucleus, reciprocal inhibitory stabilizes ring attractor encodes heading. These resemble those fly complex, showing similar circuit architecture principles may underlie across animal kingdom paving way to an unprecedented mechanistic understanding networks vertebrates.

Language: Английский

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Converting an allocentric goal into an egocentric steering signal

Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 808 - 818

Published: Feb. 7, 2024

Neuronal signals that are relevant for spatial navigation have been described in many species

Language: Английский

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Transforming a head direction signal into a goal-oriented steering command

Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 819 - 826

Published: Feb. 7, 2024

To navigate, we must continuously estimate the direction are headed in, and correct deviations from our goal

Language: Английский

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Mapping the neural dynamics of locomotion across the Drosophila brain

Current Biology, Journal Year: 2024, Volume and Issue: 34(4), P. 710 - 726.e4

Published: Jan. 21, 2024

Language: Английский

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A neural circuit architecture for rapid learning in goal-directed navigation

Neuron, Journal Year: 2024, Volume and Issue: 112(15), P. 2581 - 2599.e23

Published: May 24, 2024

Anchoring goals to spatial representations enables flexible navigation but is challenging in novel environments when both must be acquired simultaneously. We propose a framework for how Drosophila uses internal of head direction (HD) build goal upon selective thermal reinforcement. show that flies use stochastically generated fixations and directed saccades express heading preferences an operant visual learning paradigm HD neurons are required modify these based on used symmetric setting expose flies' co-evolve the reliability interacting impacts behavior. Finally, we describe rapid new headings may rest behavioral policy whose parameters form genetically encoded circuit architecture. Such evolutionarily structured architectures, which enable rapidly adaptive behavior driven by representations, relevant across species.

Language: Английский

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