Investigations of microbiota composition and neuroactive pathways in association with symptoms of stress and depression in a cohort of healthy women DOI Creative Commons
Zahra Bashir, Luisa W. Hugerth, Maria Christine Krog

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: July 2, 2024

Despite mounting evidence of gut-brain involvement in psychiatric conditions, functional data remain limited, and analyses other microbial niches, such as the vaginal microbiota, are lacking relation to mental health. This aim this study was investigate if connections between gut microbiome health observed populations with a clinical diagnosis illness extend healthy women experiencing stress depressive symptoms. Additionally, examined pathways microbiota according levels psychological Furthermore, aimed explore potential correlations parameters young without diagnoses. In cross-sectional study, 160 Danish (aged 18-40 years) filled out questionnaires validated scales measuring symptoms depression frequency dietary intake. Fecal samples were collected at beginning menstrual cycle also day 8-12 18-22. Shotgun metagenomic profiling performed. The Kyoto Encyclopedia Genes Genomes (KEGG) used for 56 Gut Brain Modules analyzed fecal samples. relative abundance genera Escherichia, Parabacteroides, Shigella higher elevated Women high perceived showed tendency increased Shigella, Blautia. Amongst others, potentially pathogenic genera, Escherichia correlate alterations neuroactive glutamatergic, GABAeric, dopaminergic, Kynurenine pathways. Vaginosis more prevalent reporting findings support concept microbiota-associated effect on even women. suggest, that targeting could be promising approach future interventions.

Language: Английский

The Microbiota–Gut–Brain Axis in Psychiatric Disorders DOI Open Access
Aleksandra Góralczyk-Bińkowska, Dagmara Szmajda‐Krygier, Elżbieta Kozłowska

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11245 - 11245

Published: Sept. 24, 2022

Modulating the gut microbiome and its influence on human health is subject of intense research. The microbiota could be associated not only with gastroenterological diseases but also psychiatric disorders. importance factors such as stress, mode delivery, role probiotics, circadian clock system, diet, occupational environmental exposure in relationship between brain function through bidirectional communication, described "the microbiome-gut-brain axis", especially underlined. In this review, we discuss link intestinal host response involving different pathways nervous system (e.g., neurotransmitters, endocrine immunological mechanisms, or bacterial metabolites). We review alterations their results development disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar (BD), autism spectrum (ASD), attention-deficit hyperactivity (ADHD).

Language: Английский

Citations

233
Associations of gut microbiota alterations with clinical, metabolic, and immune-inflammatory characteristics of chronic schizophrenia DOI
Błażej Misiak, Edyta Pawlak,

Krzysztof P. Rembacz

et al.

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 171, P. 152 - 160

Published: Jan. 23, 2024

Language: Английский

Citations

26
Lactic acid bacteria: Nature, Characterization, Mode of action, Products and Applications DOI
Patrick Othuke Akpoghelie, Great Iruoghene Edo,

Ali B.M. Ali

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

3
The gut microbiota and depressive symptoms across ethnic groups DOI Creative Commons
Jos A. Bosch, Max Nieuwdorp, Aeilko H. Zwinderman

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 6, 2022

The gut microbiome is thought to play a role in depressive disorders, which makes it an attractive target for interventions. Both the and symptom levels vary substantially across ethnic groups. Thus, any intervention depression targeting requires understanding of microbiome-depression associations ethnicities. Analysing data from HELIUS cohort, we characterize microbiota its with symptoms 6 groups (Dutch, South-Asian Surinamese, African Ghanaian, Turkish, Moroccan; N = 3211), living same urban area. Diversity microbiota, both within (α-diversity) between individuals (β-diversity), predicts levels, taking into account demographic, behavioural, medical differences. These do not differ Further, β-diversity explains 29%-18% differences symptoms. Bacterial genera associated belong mulitple families, prominently including families Christensenellaceae, Lachnospiraceae, Ruminococcaceae. In summary, results show that are linked this association generalizes Moreover, suggest may partly explain parallel disparities depression.

Language: Английский

Citations

52
Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression: towards enterotypic phenotypes DOI Creative Commons
Michaël Maes, Asara Vasupanrajit, Ketsupar Jirakran

et al.

Acta Neuropsychiatrica, Journal Year: 2023, Volume and Issue: 35(6), P. 328 - 345

Published: April 13, 2023

The first publication demonstrating that major depressive disorder (MDD) is associated with alterations in the gut microbiota appeared 2008 (Maes et al., 2008). purpose of present study to delineate a) microbiome signature phenome depression, including suicidal behaviours (SB) and cognitive deficits; effects adverse childhood experiences (ACEs) recurrence illness index (ROI) on microbiome; lowered high-density lipoprotein cholesterol (HDLc). We determined isometric log-ratio abundances or prevalences phyla, genera, species by analysing stool samples from 37 healthy Thai controls 32 MDD patients using 16S rDNA sequencing. Six taxa accounted for 36% variance depression phenome, namely Hungatella Fusicatenibacter (positive associations) Butyricicoccus, Clostridium, Parabacteroides merdae, Desulfovibrio piger (inverse association). This profile (labelled enterotype 1) indicates compositional dysbiosis, strongly predicted ACE ROI, linked SB. A second was developed a decrease HDLc an increase atherogenic plasma (Bifidobacterium, P. Romboutsia were positively associated, while Proteobacteria Clostridium sensu stricto negatively associated). Together, enterotypes 1 2 explained 40.4% conjunction 39.9% current In conclusion, microimmuneoxysome potential new drug target treatment severe SB possibly prevention future episodes.

Language: Английский

Citations

40
A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression DOI Open Access
Dinyadarshini Johnson, Vengadesh Letchumanan, C. Thum

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1382 - 1382

Published: March 13, 2023

Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents key domain healthcare, which has limited, adverse-effect prone treatment options, probiotics may hold be novel, customizable for depression. Clinical depression is common, potentially debilitating condition that amenable precision psychiatry-based approach utilizing probiotics. Although our understanding not yet reached sufficient level, this could therapeutic can tailored specific individuals with own unique set characteristics issues. Scientifically, use as valid basis rooted in microbiota-gut-brain axis (MGBA) mechanisms, play role pathophysiology theory, appear ideal adjunct therapeutics major depressive disorder (MDD) stand-alone mild MDD revolutionize disorders. there wide range an almost limitless combinations, review aims narrow focus most widely commercialized studied strains, namely Lactobacillus Bifidobacterium, bring together arguments usage patients (MDD). Clinicians, scientists, industrialists critical stakeholders exploring groundbreaking concept.

Language: Английский

Citations

30
Gut microbes in central nervous system development and related disorders DOI Creative Commons

Yumeng Gan,

Yao Chen, Huijie Zhong

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 26, 2024

The association between gut microbiota and central nervous system (CNS) development has garnered significant research attention in recent years. Evidence suggests bidirectional communication the CNS through brain-gut axis. As a long complex process, is highly susceptible to both endogenous exogenous factors. impacts by regulating neurogenesis, myelination, glial cell function, synaptic pruning, blood-brain barrier permeability, with implication various disorders. This review outlines relationship stages of (prenatal postnatal), emphasizing integral role microbes. Furthermore, explores implications neurodevelopmental disorders, such as autism spectrum disorder, Rett syndrome, Angelman offering insights into early detection, prompt intervention, innovative treatments.

Language: Английский

Citations

13
Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus DOI Creative Commons

Haili He,

Hui He, Li Mo

et al.

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 36, P. 100729 - 100729

Published: Jan. 23, 2024

Communication among the brain, gut and microbiota in is known to affect susceptibility stress, but mechanisms involved are unclear. Here we demonstrated that stress resistance mice was associated with more abundant

Language: Английский

Citations

11
Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Chenglin Ye, Zhiqiang Li, Chun Ye

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 370 - 370

Published: Feb. 11, 2024

Recent observational studies revealed an association between gut microbiota and aging, but whether are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate causal biological age acceleration using largest available GWAS summary data from MiBioGen consortium on acceleration. further conducted sensitivity analysis MR-PRESSO, MR-Egger regression, Cochran Q test, reverse MR analysis. Streptococcus (IVW, β = 0.16, p 0.0001) was Bioage Eubacterium (rectale group) 0.20, 0.0190), Sellimonas 0.06, 0.019), Lachnospira −0.18, 0.01) were suggestive of associations acceleration, latter being protective. Actinomyces 0.26, 0.0083), Butyricimonas 0.21, 0.0184), Lachnospiraceae (FCS020 0.24, 0.0194) Phenoage This study found that Further randomized controlled trials needed its role in process.

Language: Английский

Citations

10
Immune Dysfunction in Schizophrenia Spectrum Disorders DOI
Shiral S. Gangadin, Anne-Sophie D. Enthoven,

Nico J.M. van Beveren

et al.

Annual Review of Clinical Psychology, Journal Year: 2024, Volume and Issue: 20(1), P. 229 - 257

Published: July 12, 2024

Evidence from epidemiological, clinical, and biological research resulted in the immune hypothesis: hypothesis that system dysfunction is involved pathophysiology of schizophrenia spectrum disorders (SSD). The promising implication this potential to use existing immunomodulatory treatment for innovative interventions SSD. Here, we provide a selective historical review important discoveries have shaped our understanding We first explain basic principles dysfunction, after which travel more than century back time. Starting journey with neurosyphilis-associated psychosis nineteenth century, continue by evaluating role infections autoimmunity SSD findings assessment function using new techniques, such as cytokine levels, microglia density, neuroimaging, gene expression. Drawing these findings, discuss anti-inflammatory SSD, conclude look into future.

Language: Английский

Citations

8