CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia DOI Creative Commons
Thomas Farge, Jean Nakhle, Damien Lagarde

et al.

Cancer Research, Journal Year: 2023, Volume and Issue: 83(17), P. 2824 - 2838

Published: June 16, 2023

Identifying mechanisms underlying relapse is a major clinical issue for effective cancer treatment. The emerging understanding of the importance metastasis in hematologic malignancies suggests that it could also play role drug resistance and acute myeloid leukemia (AML). In cohort 1,273 AML patients, we uncovered multifunctional scavenger receptor CD36 was positively associated with extramedullary dissemination leukemic blasts, increased risk after intensive chemotherapy, reduced event-free overall survival. dispensable lipid uptake but fostered blast migration through its binding thrombospondin-1. CD36-expressing which were largely enriched exhibited senescent-like phenotype while maintaining their migratory ability. xenograft mouse models, inhibition blasts prolonged survival chemotherapy-treated mice. These results pave way development as an independent marker poor prognosis patients promising actionable target to improve outcome patients.CD36 promotes disease represents critical can be exploited patient

Language: Английский

Inflammation and aging: signaling pathways and intervention therapies DOI Creative Commons
Xia Li, Chentao Li, Wanying Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 8, 2023

Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical

Language: Английский

Citations

486
Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

197
Chronic inflammation and the hallmarks of aging DOI Creative Commons
Jordan J. Baechle, Nan Chen, Priya Makhijani

et al.

Molecular Metabolism, Journal Year: 2023, Volume and Issue: 74, P. 101755 - 101755

Published: June 16, 2023

Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.

Language: Английский

Citations

153
Hallmarks of cardiovascular ageing DOI
Mahmoud Abdellatif, Peter P. Rainer, Simon Sedej

et al.

Nature Reviews Cardiology, Journal Year: 2023, Volume and Issue: 20(11), P. 754 - 777

Published: May 16, 2023

Language: Английский

Citations

119
Exercise metabolism and adaptation in skeletal muscle DOI
Jonathon A.B. Smith, Kevin A. Murach, Kenneth A. Dyar

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(9), P. 607 - 632

Published: May 24, 2023

Language: Английский

Citations

111
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan DOI Creative Commons
Anissa A. Widjaja, Wei‐Wen Lim, Siva Viswanathan

et al.

Nature, Journal Year: 2024, Volume and Issue: 632(8023), P. 157 - 165

Published: July 17, 2024

For healthspan and lifespan, ERK, AMPK mTORC1 represent critical pathways inflammation is a centrally important hallmark

Language: Английский

Citations

68
Sarcopenic obesity: emerging mechanisms and therapeutic potential DOI Creative Commons
Christopher L. Axelrod, Wagner S. Dantas, John P. Kirwan

et al.

Metabolism, Journal Year: 2023, Volume and Issue: 146, P. 155639 - 155639

Published: June 27, 2023

Sarcopenic obesity, or the loss of muscle mass and function associated with excess adiposity, is a largely untreatable medical condition diminished quality life increased risk mortality. To date, it remains somewhat paradoxical mechanistically undefined as to why subset adults obesity develop muscular decline, an anabolic stimulus generally retention lean mass. Here, we review evidence surrounding definition, etiology, treatment sarcopenic emphasis on emerging regulatory nodes therapeutic potential. We available clinical focused diet, lifestyle, behavioral interventions improve in patients obesity. Based upon evidence, relieving consequences energy burden, such oxidative stress, myosteatosis, and/or mitochondrial dysfunction, promising area for development management

Language: Английский

Citations

60
Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) – Proceedings from the SOGLI consortium meeting in Rome November 2022 DOI
Gianluca Gortan Cappellari, Christelle Guillet, Eleonora Poggiogalle

et al.

Clinical Nutrition, Journal Year: 2023, Volume and Issue: 42(5), P. 687 - 699

Published: Feb. 24, 2023

Language: Английский

Citations

52
Stress, epigenetics, and aging: Unraveling the intricate crosstalk DOI Creative Commons
Zeming Wu, Jing Qu, Weiqi Zhang

et al.

Molecular Cell, Journal Year: 2023, Volume and Issue: 84(1), P. 34 - 54

Published: Nov. 13, 2023

Language: Английский

Citations

52
Increased cell senescence in human metabolic disorders DOI Creative Commons
Rosa Spinelli,

Ritesh K. Baboota,

Silvia Gogg

et al.

Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(12)

Published: June 14, 2023

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, increases burden of CS in all major metabolic tissues. However, also increased adult obesity, type 2 diabetes (T2D), nonalcoholic fatty liver disease independent aging. Senescent tissues are characterized by dysfunctional cells inflammation, both progenitor mature, fully differentiated nonproliferating afflicted. Recent studies have shown that hyperinsulinemia insulin resistance (IR) promote human adipose cells. Similarly, promotes cellular IR, showing their interdependence. Furthermore, T2D age, BMI, degree hyperinsulinemia, suggesting premature These results suggest senomorphic/senolytic therapy may become important for treating these common disorders.

Language: Английский

Citations

45