Neurons in the inferior colliculus use multiplexing to encode features of frequency-modulated sweeps DOI Creative Commons
Audrey C. Drotos,

Sarah Z. Wajdi,

Michael Malina

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Within the central auditory pathway, inferior colliculus (IC) is a critical integration center for ascending sound information. Previous studies have shown that many IC neurons exhibit receptive fields individual features of stimuli, such as frequency, intensity, and location, but growing evidence suggests some may multiplex sound. Here, we used in vivo juxtacellular recordings awake, head-fixed mice to examine how responded frequency-modulated sweeps varied speed, direction, frequency range. We then applied machine learning methods determine encode FM sweeps. found sweep using various strategies including spike timing, distribution inter-spike intervals, first latency. In addition, decoding accuracy direction can vary with speed range, suggesting presence mixed selectivity single neurons. Accordingly, static alone yielded poor predictions neuron responses vocalizations contain simple changes. Lastly, showed encoding across neurons, resulting highly informative population response features. Together, our results suggest multiplexing common mechanism by represent complex sounds.

Language: Английский

Detection, processing and reinforcement of social cues: regulation by the oxytocin system DOI
Rohit Menon, Inga D. Neumann

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 761 - 777

Published: Oct. 27, 2023

Language: Английский

Citations

42
Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species DOI Creative Commons
Virginie Rappeneau, Fernando Castillo Díaz

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105675 - 105675

Published: April 11, 2024

Social behaviours are essential for animal survival, and the hypothalamic neuropeptide oxytocin (OXT) critically impacts bonding, parenting, decision-making. Dopamine (DA), is released by ventral tegmental area (VTA) dopaminergic neurons, regulating social cues in mesolimbic system. Despite extensive exploration of OXT DA roles behaviour independently, limited studies investigate their interplay. This narrative review integrates insights from human studies, particularly rodents, emphasising recent research on pharmacological manipulations or systems behaviour. Additionally, we correlating with blood/cerebral levels. Behavioural facets include sociability, cooperation, pair bonding parental care. In addition, provide into OXT-DA interplay models stress, autism schizophrenia. Emphasis placed complex relationship between collective influence across physiological pathological conditions. Understanding imbalance fundamental unravelling neurobiological underpinnings interaction reward processing deficits observed psychiatric

Language: Английский

Citations

10
The thalamic reticular nucleus orchestrates social memory DOI Creative Commons

Feidi Wang,

Huan Sun,

Mingyue Chen

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2368 - 2385.e11

Published: May 2, 2024

Social memory has been developed in humans and other animals to recognize familiar conspecifics is essential for their survival reproduction. Here, we demonstrated that parvalbumin-positive neurons the sensory thalamic reticular nucleus (sTRN

Language: Английский

Citations

10
Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo DOI
Jessie Muir, Maribel Anguiano, Christina K. Kim

et al.

Science, Journal Year: 2024, Volume and Issue: 385(6716)

Published: Sept. 26, 2024

To determine how neuronal circuits encode and drive behavior, it is often necessary to measure manipulate different aspects of neurochemical signaling in awake animals. Optogenetics calcium sensors have paved the way for these types studies, allowing perturbation readout spiking activity within genetically defined cell types. However, methods lack ability further disentangle roles individual neuromodulator neuropeptides on behavior. We review recent advances chemical biology tools that enable precise spatiotemporal monitoring control over neuroeffectors their receptors vivo. also highlight discoveries enabled by such tools, revealing molecules signal across timescales learning, orchestrate behavioral changes, modulate circuit activity.

Language: Английский

Citations

9
Oxytocin receptors are widely distributed in the prairie vole (Microtus ochrogaster) brain: Relation to social behavior, genetic polymorphisms, and the dopamine system DOI
Kiyoshi Inoue, Charles L. Ford, Kengo Horie

et al.

The Journal of Comparative Neurology, Journal Year: 2022, Volume and Issue: 530(16), P. 2881 - 2900

Published: June 28, 2022

Oxytocin regulates social behavior via direct modulation of neurons, regulation neural network activity, and interaction with other neurotransmitter systems. The behavioral effects oxytocin signaling are determined by the species-specific distribution brain receptors. socially monogamous prairie vole has been a useful model organism for elucidating role in behaviors, including pair bonding, response to loss, consoling. However, there no comprehensive mapping receptor-expressing cells throughout brain. Here, we employed highly sensitive situ hybridization, RNAscope, construct an exhaustive, brain-wide map receptor mRNA-expressing cells. We found that mRNA expression was widespread diffused brain, specific areas displaying particularly robust expression. Comparing binding revealed regions hippocampus substantia nigra contained protein but lacked mRNA, indicating receptors can be transported distal neuronal processes, consistent presynaptic functions. In nucleus accumbens, region involved oxytocin-dependent detected both D1 D2 dopamine subtypes Furthermore, natural genetic polymorphisms robustly influenced cell types accumbens. Collectively, our findings further elucidate extent which is capable influencing responses stimuli, behavior. KEY POINTS: diffusely expressed strong concentrated certain localization misaligned some areas, may processes. on expressing subtypes, majority variation between animals attributable gene.

Language: Английский

Citations

37
Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles DOI Creative Commons
Amélie M. Borie, Sena Agezo,

Parker Lunsford

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(5), P. 1026 - 1037.e4

Published: Feb. 1, 2022

Language: Английский

Citations

33
Fantastic beasts and how to study them: rethinking experimental animal behavior DOI Creative Commons
Siyu Serena Ding, Jessica L. Fox, Andrew Gordus

et al.

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(4)

Published: Feb. 15, 2024

ABSTRACT Humans have been trying to understand animal behavior at least since recorded history. Recent rapid development of new technologies has allowed us make significant progress in understanding the physiological and molecular mechanisms underlying behavior, a key goal neuroethology. However, there is tradeoff when studying its biological mechanisms: common protocols laboratory are designed be replicable controlled, but they often fail encompass variability breadth natural behavior. This Commentary proposes framework 10 questions that aim guide researchers incorporating rich context into their experimental design or choosing study system. The cover overarching considerations can provide template for interspecies comparisons, enable develop studies model organisms unlock experiments our quest

Language: Английский

Citations

6
Comparison of the connectivity of the posterior intralaminar thalamic nucleus and peripeduncular nucleus in rats and mice DOI Creative Commons

Hui-Ru Cai,

Shengqiang Chen, Xiaojun Xiang

et al.

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: April 26, 2024

The posterior intralaminar thalamic nucleus (PIL) and peripeduncular (PP) are two adjoining structures located medioventral to the medial geniculate nucleus. PIL-PP region plays important roles in auditory fear conditioning social, maternal sexual behaviors. Previous studies often lumped PIL PP into single entity, therefore it is not known if they have common and/or different brain-wide connections. In this study, we investigate efferent afferent projections of using reliable anterograde retrograde tracing methods. Both project strongly lateral, anterior basomedial amygdaloid nuclei, posteroventral striatum (putamen external globus pallidus), amygdalostriatal transition area, zona incerta, superior inferior colliculi, ectorhinal cortex. However, rather than send stronger hypothalamic regions such as preoptic area/nucleus, nucleus, ventromedial hypothalamus. As for projections, both receive multimodal information from (inferior colliculus, olivary lateral lemniscus, association cortex), visual (superior colliculus somatosensory (gracile cuneate nuclei), motor (external limbic (central hypothalamus, insular cortex) structures. receives strong related parabigeminal ventral Additional results Cre-dependent viral mice also confirmed main rats. Together, findings study would provide new insights neural circuits functional correlation PP.

Language: Английский

Citations

5
Oxytocin receptors in the nucleus accumbens shell are necessary for the onset of maternal behavior DOI Creative Commons

Shannah K. Witchey,

Alexandra Haupt,

Heather K. Caldwell

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 2, 2024

In rodents, oxytocin (Oxt) contributes to the onset of maternal care by shifting perception pups from aversive attractive. Both Oxt receptor knockout (Oxtr -/-) and forebrain-specific Oxtr (FB/FB) dams abandon their first litters, likely due a failure brain 'switch' more state. Whether this behavioral shift is neurochemically similar in virgin females, who can display behaviors when repeatedly exposed pups, or what neuroanatomical substrate critical for remains unknown. To understand similarities differences signaling pup-sensitized FB/FB as opposed post-parturient -/- dams, behavior (pup-sensitized females only) immediate early gene activation were assessed. Pup-sensitized retrieved faster on day one testing had reduced c-Fos expression dorsal lateral septum compared +/+ females. This differs was observed where increased nucleus accumbens (NAcc) shell. Based these data, we then disrupted NAcc shell posterior paraventricular thalamus (pPVT) (control region) female floxed mice using Cre recombinase expressing adeno-associated virus. Knockout only prevented Our data suggest that may differ behavior.

Language: Английский

Citations

5
Population coding of time-varying sounds in the nonlemniscal inferior colliculus DOI
Kaiwen Shi, Gunnar L. Quass, Meike M. Rogalla

et al.

Journal of Neurophysiology, Journal Year: 2024, Volume and Issue: 131(5), P. 842 - 864

Published: March 20, 2024

The inferior colliculus (IC) of the midbrain is important for complex sound processing, such as discriminating conspecific vocalizations and human speech. IC's nonlemniscal, dorsal "shell" region likely this process, neurons in these layers project to higher-order thalamic nuclei that subsequently funnel acoustic signals amygdala nonprimary auditory cortices, forebrain circuits vocalization coding a variety mammals, including humans. However, extent which shell IC transmit features necessary discern less clear, owing technical difficulty recording from superficial via traditional approaches. Here, we use two-photon Ca

Language: Английский

Citations

4