Metabolic reprogramming of macrophages in cancer therapy DOI
Xudong Wang, Shaolong Zhang,

Dixuan Xue

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy DOI Creative Commons
Timothy R. McCulloch, Gustavo Rodrigues Rossi,

Socorro Miranda‐Hernandez

et al.

Immunology and Cell Biology, Journal Year: 2024, Volume and Issue: 102(8), P. 721 - 733

Published: June 14, 2024

Abstract Antibiotic resistance is a major public health threat, and alternatives to antibiotic therapy are urgently needed. Immunotherapy, particularly the blockade of inhibitory immune checkpoints, leading treatment option in cancer autoimmunity. In this study, we used murine model Salmonella Typhimurium infection investigate whether checkpoint could be applied bacterial infection. We found that T‐cell immunoglobulin ITIM domain (TIGIT) was significantly upregulated on lymphocytes during infection, CD4 + T cells, drastically limiting their proinflammatory function. Blockade TIGIT vivo using monoclonal antibodies able enhance immunity improve clearance. The efficacy anti‐TIGIT dependent capacity antibody bind Fc (fragment crystallizable) receptors, giving important insights into mechanism therapy. This research suggests targeting such as TIGIT, has potential responses toward bacteria restore antibacterial options face resistance.

Language: Английский

Citations

3
Infiltrating treg reprogramming in the tumor immune microenvironment and its optimization for immunotherapy DOI Creative Commons
Zhaokai Zhou, Jiaxin Xu, Shutong Liu

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 4, 2024

Language: Английский

Citations

3
Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection DOI
Gabriela M. Webb,

Cleiton Pessoa,

Allyson J. McCullen

et al.

Journal of Virology, Journal Year: 2024, Volume and Issue: 98(6)

Published: May 22, 2024

TIGIT is a negative immune checkpoint receptor associated with T cell exhaustion in cancer and HIV. upregulation virus-specific CD8

Language: Английский

Citations

2
Regulatory T cells: masterminds of immune equilibrium and future therapeutic innovations DOI Creative Commons
Junwei Ge,

Xuan Yin,

Lujun Chen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 3, 2024

Regulatory T cells (Tregs), a subset of CD4 + marked by the expression transcription factor forkhead box protein 3 (Foxp3), are pivotal in maintaining immune equilibrium and preventing autoimmunity. In our review, we addressed functional distinctions between Foxp3 Tregs other cells, highlighting their roles autoimmune diseases cancer. We uncovered dual nature Tregs: they prevented self-tolerance while contributing to tumor evasion suppressing anti-tumor immunity. This study underscored potential for targeted therapeutic strategies, such as enhancing Treg activity restore balance or depleting augment responses These insights laid groundwork future research clinical applications, emphasizing critical role regulation advancement next-generation immunotherapies.

Language: Английский

Citations

2
Metabolic reprogramming of macrophages in cancer therapy DOI
Xudong Wang, Shaolong Zhang,

Dixuan Xue

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

2