Cognitive maps and schizophrenia DOI Creative Commons
Matthew M. Nour, Yunzhe Liu, Mohamady El-Gaby

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Basis functions for complex social decisions in dorsomedial frontal cortex DOI Creative Commons
Marco K. Wittmann, Yongling Lin, Deng Pan

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Navigating social environments is a fundamental challenge for the brain. It has been established that brain solves this problem, in part, by representing information an agent-centric manner; knowledge about others’ abilities or attitudes tagged to individuals such as ‘oneself’ ‘other’ 1–6 . This intuitive approach informed understanding of key nodes parts brain, dorsomedial prefrontal cortex (dmPFC) and anterior cingulate (ACC) 7–9 However, patterns combinations which might interact with one another important identities individuals. Here, four studies using functional magnetic resonance imaging, behavioural experiments group decision-making task, we show dmPFC ACC represent combinatorial possibilities interaction afforded given situation, they do so compressed format resembling basis functions used spatial, visual motor domains 10–12 The align types, opposed individual identities. Our results indicate there are deep analogies between abstract neural coding schemes domain construction our sense identity.

Language: Английский

Citations

3
Hippocampal neuronal activity is aligned with action plans DOI Creative Commons
Ipshita Zutshi, Athina Apostolelli, Wannan Yang

et al.

Nature, Journal Year: 2025, Volume and Issue: 639(8053), P. 153 - 161

Published: Jan. 8, 2025

Language: Английский

Citations

2
A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps DOI Creative Commons
James C. R. Whittington, William Dorrell, Timothy E.J. Behrens

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Remembering events is crucial to intelligent behavior. Flexible memory retrieval requires a cognitive map and supported by two key brain systems: hippocampal episodic (EM) prefrontal working (WM). Although an understanding of EM emerging, little understood WM beyond simple retrieval. We develop mathematical theory relating the algorithms representations unveiling duality between storing memories in synapses versus neural activity. This results formalism as structured, controllable subspaces (activity slots) representing dynamic maps without synaptic plasticity. Using networks, we elucidate differences, similarities, trade-offs algorithms. Lastly, show that tasks from list learning cue-dependent recall are unified activity slots. Our unify frontal temporal offer new for WM.

Language: Английский

Citations

5
Neural compositions use multigoal building blocks DOI

Jake Rogers

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Replay builds an efficient cognitive map offline to avoid computation online DOI Creative Commons
Jianxin Ou,

Yukun Qu,

Yue Xu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract How do humans integrate fragmented experiences into a coherent structure for novel inferences? Although offline replay is proposed to reorganize memories, whether it constructs an integrated cognitive map remains unclear. Using magnetoencephalography, we tracked neural activity as participants learned one-dimensional, pairwise rank relationships that together formed two-dimensional (2D) conceptual map, and then inferred unobserved relationships. Offline during rest piecemeal memories 2D representation, predicting future inference accuracy. This fast on-task correlated with grid-cell-like code, representing generalizable schema minimized effortful online computations. In contrast, slow focusing on trial-specific details, negatively grid-like codes performance. Together, builds efficient offline, reducing reliance deliberate computations online.

Language: Английский

Citations

0
Cognitive neuroscience: How the brain navigates abstract task spaces DOI
Sina Tafazoli, Adel Ardalan, Timothy J. Buschman

et al.

Current Biology, Journal Year: 2025, Volume and Issue: 35(2), P. R60 - R62

Published: Jan. 1, 2025

Language: Английский

Citations

0
Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema DOI Creative Commons
Ido Maor,

James Atwell,

Ilana Ascher

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Abstract Schemas allow efficient behavior in new situations, but reliance on them can impair flexibility when demands conflict, culminating psychopathology. Evidence implicates the orbitofrontal cortex (OFC) deploying schemas situations congruent with previously acquired knowledge. But how does this role affect learning of a conflicting behavioral schema? Here we addressed question by recording single-unit activity OFC rats odor problems identical external information orthogonal rules governing reward. Consistent schema formation, representations adapted to track underlying rules, and both performance encoding was faster subsequent than initial problems. Surprisingly however, rule reward changed, persistent representation prior correlated acquisition new. Thus, not source interference instead supported accurately independently representing old as acquired.

Language: Английский

Citations

0
Neural representation of action symbols in primate frontal cortex DOI Creative Commons
Lucas Y Tian,

Kedar U. Garzón,

Adam G. Rouse

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract At the core of intelligence is proficiency in solving new problems, including those that differ dramatically from problems seen before. Problem-solving, turn, depends on goal-directed generation novel thoughts and behaviors 1 , which has been proposed to rely internal representations discrete units, or symbols, processes can recombine them into a large set possible composite 1–11 . Although this view influential formulating cognitive-level explanations behavior, definitive evidence for neuronal substrate symbols remained elusive. Here, we identify neural population encoding action symbols—internal, recombinable units motor behavior—localized specific area frontal cortex. In macaque monkeys performing drawing-like task designed assess recombination learned sequences, found behavioral three critical features indicate actions have an underlying symbolic representation: (i) invariance over low-level parameters; (ii) categorical structure, reflecting classes action; (iii) sequences. simultaneous recordings across motor, premotor, prefrontal cortex, planning-related activity ventral premotor cortex encodes manner that, like reflects invariance, recombination, properties indicating representation. Activity no other recorded exhibited combination properties. These findings reveal representation localized PMv, therefore putative cognitive operations.

Language: Английский

Citations

0
What dopamine teaches depends on what the brain believes DOI

Eleonora Bano,

Sung Ho Ryu, Ádám Kepecs

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: May 28, 2025

Language: Английский

Citations

0
Structural knowledge: from brain to artificial intelligence DOI Creative Commons
Yingchao Yu, Yuping Yan, Yaochu Jin

et al.

Artificial Intelligence Review, Journal Year: 2025, Volume and Issue: 58(9)

Published: June 4, 2025

Language: Английский

Citations

0