Single-cell immunology: Past, present, and future

Immunity, Journal Year: 2022, Volume and Issue: 55(3), P. 393 - 404

Published: March 1, 2022

Language: Английский

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The role of gut microbiota in T cell immunity and immune mediated disorders

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(4), P. 1178 - 1191

Published: Jan. 1, 2023

Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed the microbiome play critical role both physiological and pathological immune system.The gut composition is altered by environmental factors such diet hygiene, alteration affects cells, especially T cells.Advanced genomic techniques research defined specific microbes regulate cell responses pathogenesis of immune-mediated disorders.Here, we review features microbes-T crosstalk relationship between immunopathogenesis diseases including cancers, autoimmune disorders allergic inflammations.We also discuss limitations current experimental animal models, cutting-edge developments challenges to overcome field, possibility considering development new drug.

Language: Английский

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Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(12), P. 1502 - 1514

Published: Oct. 26, 2023

Language: Английский

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The role of inflammation in autoimmune disease: a therapeutic target

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 4, 2023

Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence increasing year by year. AIDs produced the system’s misidentification of self-antigens, seemingly caused excessive function, but in fact they result reduced accuracy due to decline system which cannot clearly identify foreign invaders thus issuing false attacks, eventually leading disease. The occurrence is often accompanied emergence inflammation, inflammatory mediators (inflammatory factors, inflammasomes) play an important role pathogenesis AIDs, mediate process affecting innate cells (such as macrophages) adaptive T B cells), ultimately promote autoimmune responses, so targeting mediators/pathways one emerging treatment strategies AIDs. This review will briefly describe inflammation different give a rough introduction inhibitors hoping have reference significance for subsequent options

Language: Английский

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Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(2), P. 299 - 315.e8

Published: Feb. 1, 2023

Language: Английский

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