Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3647 - 3647

Published: Aug. 20, 2023

The first 1000 days after birth represent a critical window for gut microbiome development, which is essential immune system maturation and overall health. undergoes major changes during this period due to shifts in diet environment. Disruptions the microbiota early life can have lasting health effects, including increased risks of inflammatory disorders, autoimmune diseases, neurological obesity. Maternal environmental factors pregnancy infancy shape infant microbiota. In article, we will review how maintaining healthy important long-term Furthermore, briefly include fungal colonization its effects on host function, are discussed as part ecosystem. Additionally, describe potential approaches such hydrogels enriched with prebiotics probiotics, transplantation (GMT) pregnancy, age-specific microbial ecosystem therapeutics, CRISPR therapies targeting hold advancing research development. Nevertheless, thorough evaluation their safety, effectiveness, impacts crucial prior application clinical approach. article emphasizes need continued optimize development through targeted early-life interventions.

Language: Английский

---

Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 2956 - 2956

Published: June 29, 2023

The immune system is vital for safeguarding the human body against infections and inflammatory diseases. role of diet meal patterns in modulating function complex, highlighting this topic crucial identifying potential ways to improve health. In Europe, Mediterranean Western are most common dietary patterns, gaining an understanding how they affect essential public There numerous diseases that observed younger older people. Some include polymyalgia rheumatica (PMR), spinal muscular atrophy (SMA), vasculitis, sarcopenia, cirrhosis, cancer, fibromyalgia, but main focus review article on irritable bowel disease (IBD). general, choices can have immense impact microbial flora gut people with intake Mediterranean-style foods promotes growth healthy bacteria enhances system. On other hand, it mostly seen Western-style leads harmful contributes inflammation development by weakening Additionally, brain function, leading mood disorders, such as anxiety depression. Rare diseases, psoriasis sarcoidosis, interest article. All above-mentioned rare a certain relationship microbiota gut. microbiome plays significant IBD; fiber prebiotic interventions may represent promising adjunct therapies pediatric IBD targeting microbiome. By advancing good overall arrangement microorganisms stomach through mediations, working side effects alleviating might be conceivable. affected differently various fatty acid types. also involvement genetics progression IBD, transcriptional factors, one gene LCT gene, which encodes lactase, enzyme responsible digesting lactose

Language: Английский

---

Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102196 - 102196

Published: Jan. 12, 2024

Language: Английский

---

Indole-3-acetic acid alleviates DSS-induced colitis by promoting the production of R-equol from Bifidobacterium pseudolongum

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 25, 2024

Background Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence IBD driven complex interactions multiple factors. objective this study was to evaluate therapeutic effects IAA in colitis.

Language: Английский

---

Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Gastric cancer is a common malignant tumor of the digestive tract, and its treatment remains significant challenge. In recent years, role various immune cells in microenvironment progression has gained increasing attention. Immunotherapy, primarily based on checkpoint inhibitors, notably improved prognosis patients with gastric cancer; however, challenges regarding therapeutic efficacy persist. Histological features within microenvironment, such as tertiary lymphoid structures (TLSs), tumor-infiltrating lymphocytes, proportion intratumoral stroma, are emerging potentially effective prognostic factors. cancer, TLSs may serve local hubs, enhancing ability to interact recognize antigens, which closely linked effectiveness immunotherapy survival rates patients. However, specific cell type driving TLS formation tumors not yet been elucidated. Mature B-cell regions containing germinal centers. During center formation, B undergo transformations become mature function, exerting anti-tumor effects. Therefore, targeting could provide new avenues for immunotherapy. This review, combined current research elaborates relationship between aiming guidance precise

Language: Английский

---

The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106799 - 106799

Published: May 19, 2023

Depression is the most prevalent mental disorder in world associated with huge socio-economic consequences. While depressive-related symptoms are well known, molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) emerging as a key regulator of central nervous system homeostasis by exerting fundamental immune metabolic functions. In turn, brain influences intestinal microbial composition through neuroendocrine signals, within so-called microbiota-brain axis. balance this bidirectional crosstalk important to ensure neurogenesis, preserve integrity blood-brain barrier avoid neuroinflammation. Conversely, dysbiosis permeability negatively affect development, behavior, cognition. Furthermore, although not fully defined yet, changes GM depressed patients reported influence pharmacokinetics common antidepressants affecting their absorption, metabolism, activity. Similarly, neuropsychiatric drugs may shape turn an impact on efficacy toxicity pharmacological intervention itself. Consequently, strategies aimed at re-establishing correct homeostatic (i.e., prebiotics, probiotics, fecal transplantation, dietary interventions) represent innovative approach improve pharmacotherapy depression. Among these, probiotics Mediterranean diet, alone or combination standard care, hold promise for clinical application. Therefore, disclosure intricate network between depression will give precious insights diagnostic therapeutic approaches towards depression, profound implications drug development practice.

Language: Английский

---

Relationship between Gut Microbiota and Allergies in Children: A Literature Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2529 - 2529

Published: May 29, 2023

The intestinal microbiota is a diverse and complex microecosystem that lives thrives within the human body. stabilizes by age of three. This plays crucial role in health, particularly early years life. Dysbiosis has been linked to development various allergic diseases with potential long-term implications. Next-generation sequencing methods have established are associated dysbiosis. These can help improve knowledge relationship between dysbiosis diseases. aim this review paper synthesize current understanding on children, impact Furthermore, we examine connection microbiome specific allergies such as atopic dermatitis, asthma, food allergies, which mechanisms could determine induction these will how factors mode delivery, antibiotic use, breastfeeding, environment influence flora, well interventions for prevention treatment gut microbiota-related allergies.

Language: Английский

---

The Role of Bacteriophages in the Gut Microbiota: Implications for Human Health

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2416 - 2416

Published: Oct. 3, 2023

Bacteriophages (phages) are nano-sized viruses characterized by their inherent ability to live off bacteria. They utilize diverse mechanisms absorb and gain entry into the bacterial cell wall via release of viral genetic material, which uses replication host bacteria produce daughter progeny virions that attack surrounding cells. possess specific characteristics, including specificity for particular or closely related species. have many applications, as potential alternatives antibiotics against multi-resistant pathogens control agents in bacteria-contaminated environments. ubiquitously abundant nature biota, gut. Gut microbiota describes community interactions microorganisms within intestine. As with bacteria, parasitic bacteriophages constantly interact cells gut system obvious implications human health. However, it is imperative understand these they open up possible applicable techniques gut-implicated diseases. Thus, this review aims explore communities current impacts on

Language: Английский

---

Immune Cells, Gut Microbiota, and Vaccines: A Gender Perspective

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 526 - 526

Published: March 17, 2024

The development of preventive and therapeutic vaccines has played a crucial role in preventing infections treating chronic non-communicable diseases, respectively. For long time, the influence sex differences on modifying health disease not been addressed clinical preclinical studies. interaction genetic, epigenetic, hormonal factors plays sex-related epidemiology manifestations, response to treatment. Moreover, is one leading influencing gut microbiota composition, which could further explain different predisposition diseases men women. In same way, between sexes occur also immune vaccines. This narrative review aims highlight these differences, focusing Comparative data about responses, vaccine effectiveness, side effects are reviewed. Hence, intricate interplay sex, immunity, will be discussed for its potential vaccination. Embracing sex-oriented perspective research may improve efficacy allow design tailored schedules.

Language: Английский

---

Exploring the complex interplay: gut microbiome, stress, and leptospirosis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 27, 2024

Leptospirosis, a re-emerging zoonotic disease, remains significant global health concern, especially amid floods and disasters such as the Kakhovka Dam destruction. As is known, stress that occurs in conditions of military conflicts among civilian personnel significantly affects susceptibility to infectious diseases possibly even influences their course. This review aims explore how gut microbiome mediators (such catecholamines corticosteroids) might impact leptospirosis disease The opens new horizons for research by elucidating connections between microbiome, stress, leptospirosis.

Language: Английский

---