Nature Aging, Journal Year: 2024, Volume and Issue: 4(7), P. 949 - 968
Published: June 25, 2024
Language: Английский
Nature, Journal Year: 2023, Volume and Issue: 624(7990), P. 164 - 172
Published: Dec. 6, 2023
Abstract Animal studies show aging varies between individuals as well organs within an individual 1–4 , but whether this is true in humans and its effect on age-related diseases unknown. We utilized levels of human blood plasma proteins originating from specific to measure organ-specific differences living individuals. Using machine learning models, we analysed 11 major estimated organ age reproducibly five independent cohorts encompassing 5,676 adults across the lifespan. discovered nearly 20% population strongly accelerated one 1.7% are multi-organ agers. Accelerated confers 20–50% higher mortality risk, relate faster those organs. find with heart have a 250% increased failure risk brain vascular predict Alzheimer’s disease (AD) progression independently pTau-181 (ref. 5 ), current best blood-based biomarker for AD. Our models link calcification, extracellular matrix alterations synaptic protein shedding early cognitive decline. introduce simple interpretable method study using proteomics data, predicting effects.
Language: Английский
Citations
226
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(2), P. 360 - 372
Published: Feb. 1, 2024
Language: Английский
Citations
110
ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 15(1), P. 1 - 30
Published: Dec. 14, 2023
Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.
Language: Английский
Citations
54
Molecular Cell, Journal Year: 2023, Volume and Issue: 84(1), P. 34 - 54
Published: Nov. 13, 2023
Language: Английский
Citations
52
Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: 20(9), P. 569 - 585
Published: July 18, 2024
Language: Английский
Citations
35
Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 319 - 338
Published: Jan. 21, 2024
Language: Английский
Citations
22
Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(4), P. 259 - 272
Published: March 19, 2024
Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle could mark a shift in aging. We review emerging evidence on multiple levels analysis indicating midlife is defined by unique central peripheral processes shape future trajectories health. Informed developments aging lifespan studies humans animal models, we highlight utility modeling non-linear changes study samples with wide subject ranges distinguish stage-specific from those acting linearly throughout lifespan.
Language: Английский
Citations
21
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 23, 2024
Abstract The complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three age gaps (BAG) derived from gray matter volume (GM-BAG), white microstructure (WM-BAG), and functional connectivity (FC-BAG). We identified sixteen genomic loci that reached genome-wide significance (P-value < 5×10 −8 ). A gene-drug-disease network highlighted genes linked to GM-BAG for treating neurodegenerative neuropsychiatric disorders WM-BAG cancer therapy. displayed most pronounced heritability enrichment in variants within conserved regions. Oligodendrocytes astrocytes, but not neurons, exhibited notable WM FC-BAG, respectively. Mendelian randomization potential causal effects several chronic diseases on aging, such as type 2 diabetes AD WM-BAG. Our results provide insights into genetics with clinical implications lifestyle therapeutic interventions. All are publicly available at https://labs.loni.usc.edu/medicine .
Language: Английский
Citations
21
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(12), P. 3646 - 3657
Published: Aug. 26, 2024
Abstract Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex neurodegeneration) on brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American Caribbean (LAC) 8 non-LAC countries). Based higher-order interactions, we developed a deep learning architecture functional magnetic resonance imaging (2,953) electroencephalography (2,353). The comprised healthy controls individuals with mild cognitive impairment, Alzheimer disease behavioral variant frontotemporal dementia. LAC models evidenced older ages (functional imaging: mean directional error = 5.60, root square (r.m.s.e.) 11.91; electroencephalography: 5.34, r.m.s.e. 9.82) associated frontoposterior networks compared models. Structural socioeconomic inequality, pollution disparities were influential predictors increased gaps, especially in ( R ² 0.37, F 0.59, 6.9). An ascending to impairment was found. In LAC, observed larger gaps females control groups respective males. results not explained by variations signal quality, demographics or acquisition methods. These findings provide quantitative framework capturing accelerated aging.
Language: Английский
Citations
21
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 28, 2024
Abstract The design of human model systems is highly relevant to unveil the underlying mechanisms aging and provide insights on potential interventions extend health life span. In this perspective, we explore 2D or 3D culture models comprising induced pluripotent stem cells transdifferentiated obtained from aged age-related disorder-affected donors enhance our understanding catalyze discovery anti-aging interventions.
Language: Английский
Citations
18