Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1805 - 1819
Published: Sept. 21, 2023
The prefrontal cortex (PFC) enables mammals to respond situations, including internal states, with appropriate actions. One such state could be 'tiredness'. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFC
Language: Английский
Science, Journal Year: 2020, Volume and Issue: 367(6476), P. 440 - 445
Published: Jan. 24, 2020
Interneurons control brain arousal states The underlying circuit mechanisms coordinating and motor activity are poorly understood. Liu et al. found that glutamic acid decarboxylase 2 (GAD2)–expressing, but not parvalbumin-expressing, interneurons in a part of the known as substantia nigra promote sleep (see Perspective by Wisden Franks). Parvalbuminergic neurons fire at higher rates high activity, their activation increases movement termination consistent with function suppressing unwanted movements during action selection. By contrast, GAD2 preferentially active low activity. In addition to suppression, powerfully enhances transition from quiet wakefulness sleep, which differ mainly level rather than behavior. thus provide general suppression both quiescence. Science , this issue p. 440 ; see also 366
Language: Английский
Citations
115
Neuron, Journal Year: 2019, Volume and Issue: 103(5), P. 891 - 908.e6
Published: July 2, 2019
Language: Английский
Citations
112
Neuropharmacology, Journal Year: 2020, Volume and Issue: 167, P. 107993 - 107993
Published: Feb. 6, 2020
Language: Английский
Citations
112
International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(11), P. 2780 - 2780
Published: June 6, 2019
Sleep is essential for health. Indeed, poor sleep consistently linked to the development of systemic disease, including depression, metabolic syndrome, and cognitive impairments. Further evidence has accumulated suggesting role in cancer initiation progression (primarily breast cancer). patients with survivors frequently experience sleep, manifesting as insomnia, circadian misalignment, hypersomnia, somnolence hot flushes, nightmares. These problems are associated a reduction patients’ quality life increased mortality. Due heterogeneity among cancers, treatment regimens, patient populations lifestyle factors, etiology cancer-induced disruption largely unknown. Here, we discuss recent advances understanding pathways linking brain how this leads altered patterns. We describe conceptual framework where tumors disrupt normal homeostatic processes, resulting aberrant changes physiology behavior that detrimental Finally, knowledge can be leveraged develop novel therapeutic approaches cancer-associated disruption, special emphasis on host-tumor interactions.
Language: Английский
Citations
104
Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13
Published: July 17, 2019
Roughly one-third of the human lifetime is spent in sleep, yet reason for sleep remains unclear. Understanding physiologic function crucial toward establishing optimal health. Several proposed concepts address different aspects physiology, including humoral and circuit-based theories sleep-wake regulation, homeostatic two-process model theory as a state adaptive inactivity, observations that arousal homeostasis can be dissociated pathologic disorders. Currently, there no places regulation unified conceptual framework. Adenosine well known somnogenic substance affects normal patterns through several mechanisms various brain locations via A1 or A2A receptors (A1Rs A2ARs). Many cells processes appear to play role modulating extracellular concentration adenosine at neuronal A1R A2AR sites. Emerging evidence suggests A1Rs A2ARs have roles sleep. In this review, we propose which allow i.e., these provide gating, whereas modulate are essential expression resolution need. model, considered established absence arousing inputs.
Language: Английский
Citations
85
Science Advances, Journal Year: 2020, Volume and Issue: 6(45)
Published: Nov. 6, 2020
A hypothalamic neuronal circuit mediates circadian-regulated wakefulness in mice.
Language: Английский
Citations
82
British Journal of Pharmacology, Journal Year: 2019, Volume and Issue: 177(24), P. 5437 - 5458
Published: July 26, 2019
Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival of mammalian species by endowing brain neuronal networks with ability to make continual adjustments function response moment‐to‐moment changes physiological input. Here, we summarize progress field argue NO‐synthetizing neurons NO signalling provide core hub for integrating sensory‐ homeostatic‐related cues, control bodily functions, potential target new therapeutic opportunities against several neuroendocrine behavioural abnormalities.
Language: Английский
Citations
78
Molecular Pharmacology, Journal Year: 2020, Volume and Issue: 98(4), P. 445 - 453
Published: March 20, 2020
Millions of Americans suffer from opiate use disorder, and over 100 die every day opioid overdoses. Opioid often progresses into a vicious cycle abuse withdrawal, resulting in very high rates relapse. Although the physical psychologic symptoms withdrawal are well-documented, sleep disturbances caused by chronic exposure less well-understood. These substances can significantly disrupt acutely long term. Yet poor may influence use, suggesting bidirectional feed-forward interaction between use. The neurobiology how opioids affect disrupted affects is not Here, we will summarize what known about effects on electroencephalographic humans animal models. We then discuss interface reward-related brain regions that mediate arousal wakefulness as well effect sleep-related neurotransmitter systems. Finally, mechanisms underlying sleep. A critical review such studies, recommendations studies evaluate impact manipulating during further our understanding cyclical feedback
Language: Английский
Citations
78
Molecular Psychiatry, Journal Year: 2020, Volume and Issue: 26(7), P. 2912 - 2928
Published: Oct. 14, 2020
Abstract The ventral pallidum (VP) regulates motivation, drug addiction, and several behaviors that rely on heightened arousal. However, the role underlying neural circuits of VP in control wakefulness remain poorly understood. In present study, we sought to elucidate specific GABAergic neurons controlling sleep–wake mice. Fiber photometry revealed population activity was increased during physiological transitions from non-rapid eye movement (non-REM, NREM) sleep either or REM sleep. Moreover, chemogenetic optogenetic manipulations were leveraged investigate a potential causal initiating and/or maintaining vivo stimulation innervating tegmental area (VTA) strongly promoted arousal via disinhibition VTA dopaminergic neurons. Functional vitro mapping neurons, principle, inhibited but also addition, terminals they by lateral hypothalamus, not mediodorsal thalamus habenula. chemogenetically evoked neuronal activation completely abolished pretreatment with D 1 2 /D 3 receptor antagonists. Furthermore, exploration time both open-field light–dark box tests did modulate depression-like food intake. Finally, inhibition decreased Taken together, our findings indicate are essential for related motivation.
Language: Английский
Citations
77
Nature Neuroscience, Journal Year: 2022, Volume and Issue: 26(2), P. 196 - 212
Published: Dec. 29, 2022
Language: Английский
Citations
68