Obstetrics and Gynecology,
Journal Year:
2020,
Volume and Issue:
137(1), P. 91 - 99
Published: Dec. 1, 2020
OBJECTIVE:
To
evaluate
the
prevalence
and
characteristics
of
recreational
cannabis
use
in
women
with
pelvic
pain,
to
examine
influence
legalization
on
these
parameters.
METHODS:
We
conducted
a
retrospective
analysis
prospective
registry
self-reported
moderate-to-severe
pain
referred
tertiary
care
clinic
Vancouver,
Canada,
2013–2019.
excluded
patients
aged
18
years
or
younger
those
unknown
data
use.
Demographic,
clinical,
validated
questionnaire
were
extracted
for
two
main
analyses:
1)
comparison
current
users
nonusers,
2)
who
entered
before
(October
17,
2018)
after
legalization.
RESULTS:
Overall,
14.9%
(509/3,426)
classified
as
users.
Compared
(
P
<.001),
had
lower
levels
education
<.001)
household
income
taking
opioids
antiinflammatories
=.003),
neuromodulators
=.020),
herbal
medications
more
frequently.
They
worse
scores
depression,
anxiety,
catastrophizing,
quality
life,
severity
<.001
all).
After
legalization,
increased
from
13.3%
(366/2,760)
21.5%
(143/666)
<.001).
prelegalization,
postlegalization
associated
higher
anxiety
=.036),
catastrophizing
scores.
fewer
neuroleptics
=.027)
daily
narcotics
=.026),
but
=.010).
CONCLUSION:
Recreational
among
Canada.
Cannabis
pain-related
morbidities.
Postlegalization,
less
likely
require
compared
The
role,
perceived
benefits,
possible
risks
further
investigation.
CLINICAL
TRIAL
REGISTRATION:
ClinicalTrials.gov,
NCT02911090.
International Journal of Drug Policy,
Journal Year:
2021,
Volume and Issue:
99, P. 103381 - 103381
Published: Aug. 28, 2021
Cannabis
use
is
common,
especially
among
young
people,
and
associated
with
risks
for
various
health
harms.
Some
jurisdictions
have
recently
moved
to
legalization/regulation
pursuing
public
goals.
Evidence-based
'Lower
Risk
Use
Guidelines'
(LRCUG)
recommendations
were
previously
developed
reduce
modifiable
risk
factors
of
cannabis-related
adverse
outcomes;
related
evidence
has
evolved
substantially
since.
We
aimed
review
new
scientific
develop
comprehensively
up-to-date
LRCUG,
including
their
recommendations,
on
this
basis.
Targeted
searches
literature
(since
2016)
main
outcomes
by
the
user-individual
conducted.
Topical
areas
informed
previous
LRCUG
content
expanded
upon
current
evidence.
Searches
preferentially
focused
systematic
reviews,
supplemented
key
individual
studies.
The
results
evidence-graded,
topically
organized
narratively
summarized;
through
an
iterative
expert
consensus
development
process.
A
substantial
body
cannabis
use-related
harms
identified
varying
quality.
Twelve
substantive
recommendation
clusters
three
precautionary
statements
developed.
In
general,
suggests
that
individuals
can
if
they
delay
onset
until
after
adolescence,
avoid
high-potency
(THC)
products
high-frequency/-intensity
use,
refrain
from
smoking-routes
administration.
While
people
are
particularly
vulnerable
harms,
other
sub-groups
(e.g.,
pregnant
women,
drivers,
older
adults,
those
co-morbidities)
advised
exercise
particular
caution
risks.
Legal/regulated
should
be
used
where
possible.
result
in
outcomes,
mostly
higher-risk
use.
Reducing
help
offer
one
targeted
intervention
component
within
a
comprehensive
approach
They
require
effective
audience-tailoring
dissemination,
regular
updating
as
become
available,
evaluated
impact.
Proceedings of the National Academy of Sciences,
Journal Year:
2021,
Volume and Issue:
118(47)
Published: Nov. 15, 2021
Significance
Cannabis
use
is
becoming
more
prevalent,
including
during
developmentally
sensitive
periods
such
as
pregnancy.
Here
we
find
that
maternal
cannabis
associated
with
increased
cortisol,
anxiety,
aggression,
and
hyperactivity
in
young
children.
This
corresponded
widespread
reductions
immune-related
gene
expression
the
placenta
which
correlated
anxiety
hyperactivity.
Future
studies
are
needed
to
examine
effects
of
on
immune
function
pregnancy
a
potential
regulatory
mechanism
shaping
neurobehavioral
development.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(22)
Published: May 29, 2024
While
our
understanding
of
the
nanoscale
architecture
anterograde
synaptic
transmission
is
rapidly
expanding,
qualitative
and
quantitative
molecular
principles
underlying
distinct
mechanisms
retrograde
communication
remain
elusive.
We
show
that
a
particular
form
tonic
cannabinoid
signaling
essential
for
setting
target
cell-dependent
variability.
It
does
not
require
activity
two
major
endocannabinoid-producing
enzymes.
Instead,
by
developing
workflow
physiological,
anatomical,
measurements
at
same
unitary
synapse,
we
demonstrate
stoichiometric
ratio
type
1
receptors
(CB
The
pandemic
caused
by
Sars-CoV-2
(COVID-19)
has
been
a
great
concern
for
public
and
mental
health
systems
worldwide.
identification
of
risk
groups
is
essential
the
establishment
preventive
therapeutic
strategies,
as
substance
users.
During
COVID-19
pandemic,
there
was
an
increase
in
use
psychoactive
substances
during
lockdown,
including
cannabis.
This
commentary
reviews
relevant
findings
discusses
scientific
evidence
on
risks
worse
clinical
psychiatric
complications
due
to
coronavirus
disease
subjects
who
Although
they
are
not
included
group
recommendations
that
disease,
may
have
more
vulnerable
respiratory
system
viral
diseases.
There
certain
similarities
between
harmful
cardiovascular
effects
cannabis
those
smoking.
Due
different
modes
smoking,
chemicals
retained
body
longe
also
contain
other
toxic
such
tar,
found
tobacco
which
associated
with
development
lung
cancer,
bronchitis
pulmonary
emphysema.
Therefore,
we
discuss
if
individuals
regularly
might
be
infection.
population
deserves
attention
worldwide
this
manuscript
can
help
clinicians
become
aware
pandemics
develop
specific
intervention
strategies.
Substance
use,
including
cigarettes
and
cannabis,
is
associated
with
poorer
sustained
attention
in
late
adolescence
early
adulthood.
Previous
studies
were
predominantly
cross-sectional
or
under-powered
could
not
indicate
if
impairment
was
a
predictor
of
substance-use
marker
the
inclination
to
engage
such
behaviour.
This
study
explored
relationship
between
substance
use
across
longitudinal
span
from
ages
14
23
over
1,000
participants.
Behaviours
brain
connectivity
diminished
at
age
predicted
subsequent
increases
cannabis
cigarette
smoking,
establishing
as
robust
biomarker
for
vulnerability
use.
Individual
differences
network
strength
relevant
preserved
developmental
stages
networks
generalized
participants
an
external
dataset.
In
summary,
are
robust,
consistent,
able
predict
aspects
later
use.A
predicts
23.
