Neuronal coupling modes show differential development in the early cortical activity networks of human newborns DOI
Pauliina Yrjölä, Sampsa Vanhatalo, Anton Tokariev

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(26), P. e1012232024 - e1012232024

Published: May 20, 2024

The third trimester is a critical period for the development of functional networks that support lifelong neurocognitive performance, yet emergence neuronal coupling in these poorly understood. Here, we used longitudinal high-density electroencephalographic recordings from preterm infants during 33 to 45 weeks conceptional age (CA) characterize early spatiotemporal patterns local cortical function and intrinsic modes [ICMs; phase–phase (PPCs), amplitude–amplitude (AACs), phase–amplitude correlations (PACs)]. Absolute power showed robust increase with CA across full frequency spectrum, while PACs sleep state-specific, biphasic peaked few before normal birth. AACs distant decreased globally at nearly all frequencies. In contrast, PPCs frequency- region-selective development, an strength between frontal, central, occipital regions low-delta alpha frequencies together wider-spread decrease other Our findings present spectrally spatially differential distinct ICMs neonatal provide their developmental templates future basic clinical research.

Language: Английский

Development of Human Lateral Prefrontal Sulcal Morphology and Its Relation to Reasoning Performance DOI Creative Commons
Ethan H. Willbrand, Emilio Ferrer, Silvia A. Bunge

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(14), P. 2552 - 2567

Published: Feb. 24, 2023

Previous findings show that the morphology of folds (sulci) human cerebral cortex flatten during postnatal development. However, previous studies did not consider relationship between sulcal and cognitive development in individual participants. Here, we fill this gap knowledge by leveraging cross-sectional morphologic neuroimaging data lateral PFC (LPFC) from participants (6-36 years old, males females;

Language: Английский

Citations

29
Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology DOI Creative Commons

Peibin Zou,

Chongyun Wu,

Timon Cheng‐Yi Liu

et al.

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Nov. 14, 2023

Abstract Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and phagocytosis, communicating with neighboring contributing to the integrity of blood–brain barrier (BBB). However, under pathological circumstances Alzheimer’s disease (AD), brain’s microenvironment undergoes detrimental changes that significantly impact OPCs their functions. Starting OPC functions, we delve into transformation myelin-producing oligodendrocytes, intricate signaling interactions other central nervous system (CNS), fascinating process which influences function affects CNS homeostasis. Moreover, discuss essential role BBB highlight critical contribution forming CNS-protective barriers. In context AD, deterioration local brain is discussed, mainly focusing on neuroinflammation, oxidative stress, accumulation toxic proteins. The disturb delicate balance brain, impacting regenerative capacity compromising integrity. Under conditions, experience significant alterations migration proliferation, leading impaired differentiation a reduced ability produce mature oligodendrocytes. degeneration become increasingly active progressive neurodegeneration. Finally, summarize current therapeutic approaches targeting AD. Strategies revitalize senescence, modulate pathways enhance differentiation, explore potential avenues are promising alleviating AD function. conclusion, this review highlights indispensable involvement pathogenesis interplay between underscores complexity neurodegenerative diseases. Insights from studying conditions provide foundation for innovative strategies fostering Future research will advance our understanding management diseases, ultimately offering hope effective treatments improved quality life those affected by related disorders.

Language: Английский

Citations

26
Perspectives on the Novel Multifunctional Nerve Guidance Conduits: From Specific Regenerative Procedures to Motor Function Rebuilding DOI
Weixian Zhou, Muhammad Saif Ur Rahman, Chengmei Sun

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(14)

Published: Sept. 26, 2023

Peripheral nerve injury potentially destroys the quality of life by inducing functional movement disorders and sensory capacity loss, which results in severe disability substantial psychological, social, financial burdens. Autologous grafting has been commonly used as treatment clinic; however, its rare donor availability limits application. A series artificial guidance conduits (NGCs) with advanced architectures are also proposed to promote injured peripheral regeneration, is a complicated process from axon sprouting targeted muscle reinnervation. Therefore, exploring interactions between sophisticated NGC complexes versatile cells during each including sprouting, Schwann cell dedifferentiation, myelination, reinnervation necessary. This review highlights contribution NGCs influence microscale biomaterial architecture on biological processes repair. Progressive chemical molecule induction, heterogenous topographical morphology, electroactive, anisotropic assembly microstructure, self-powered electroactive magnetic-sensitive collected, they expected be pioneering features future multifunctional effective NGCs.

Language: Английский

Citations

25
White matter injury across neurodegenerative disease DOI
Lindsay Festa, Judith B. Grinspan, Kelly L. Jordan‐Sciutto

et al.

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 47(1), P. 47 - 57

Published: Dec. 4, 2023

Language: Английский

Citations

25
Combining a Density Gradient of Biomacromolecular Nanoparticles with Biological Effectors in an Electrospun Fiber‐Based Nerve Guidance Conduit to Promote Peripheral Nerve Repair DOI Creative Commons

Binghui Jin,

Yiling Yu,

Chenghao Lou

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 10(4)

Published: Dec. 9, 2022

Peripheral nerve injury is a serious medical problem with limited surgical and clinical treatment options. It of great significance to integrate multiple guidance cues in one platform conduits (NGCs) promote axonal elongation functional recovery. Here, multi-functional NGC constructed regeneration by combining ordered topological structure, density gradient biomacromolecular nanoparticles, controlled delivery biological effectors provide the topographical, haptotactic, cues, respectively. On surface aligned polycaprolactone nanofibers, bioactive nanoparticles capable delivering recombinant human acidic fibroblast growth factor deposited. graded scaffold, proliferation Schwann cells promoted, directional extension neurites from both PC12 dorsal root ganglions improved direction increasing particle density. After being implanted vivo for 6 12 weeks repair 10-mm rat sciatic defect, promotes remyelination, achieving not only anatomical structure but also Taken together, provides favorable microenvironment peripheral holds promise realizing an efficacy close autograft.

Language: Английский

Citations

34
Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development DOI Creative Commons
Samu Kurki, Pavel Uvarov, Alexey S. Pospelov

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(10), P. 5906 - 5923

Published: Dec. 27, 2022

Abstract The Na-K-2Cl cotransporter NKCC1 is widely expressed in cells within and outside the brain. However, our understanding of its roles brain functions throughout development, as well neuropsychiatric neurological disorders, has been severely hindered by lack reliable data on developmental (sub)cellular expression patterns. We provide here first properly controlled analysis protein various cell types mouse using custom-made antibodies an knock-out validated immunohistochemical procedure, with parallel based advanced mRNA approaches. are at remarkably high levels oligodendrocytes. In immature neurons, was located somata, whereas adult only could be clearly detected. immunoreactivity also seen microglia, astrocytes, developing pericytes, progenitor dentate gyrus. Finally, a differential splice variants observed, NKCC1a predominating non-neuronal NKCC1b neurons. Taken together, cellular basis for enable identification major limitations promises development neuron-targeting NKCC1-blockers.

Language: Английский

Citations

33
The long noncoding RNA FEDORA is a cell type– and sex-specific regulator of depression DOI Creative Commons
Orna Issler, Yentl Y. van der Zee, Aarthi Ramakrishnan

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(48)

Published: Nov. 30, 2022

Women suffer from depression at twice the rate of men, but underlying molecular mechanisms are poorly understood. Here, we identify marked baseline sex differences in expression long noncoding RNAs (lncRNAs), a class regulatory transcripts, human postmortem brain tissue that profoundly lost depression. One such lncRNA, RP11-298D21.1 (which termed FEDORA), is enriched oligodendrocytes and neurons up-regulated prefrontal cortex (PFC) depressed females only. We found virally expressing FEDORA selectively either or PFC promoted depression-like behavioral abnormalities female mice only, changes associated with cell type–specific regulation synaptic properties, myelin thickness, gene expression. also blood levels have diagnostic implications for women clinical response to ketamine. These findings demonstrate important role played by lncRNAs, particular, shaping sex-specific landscape contributing

Language: Английский

Citations

29
Functional and microstructural plasticity following social and interoceptive mental training DOI Creative Commons
Sofie L. Valk, Philipp Kanske, Bo‐yong Park

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 7, 2023

The human brain supports social cognitive functions, including Theory of Mind, empathy, and compassion, through its intrinsic hierarchical organization. However, it remains unclear how the learning refinement skills shapes function structure. We studied if different types mental training induce changes in cortical microstructure, investigating 332 healthy adults (197 women, 20–55 years) with repeated multimodal neuroimaging behavioral testing. Our approach examined longitudinal functional gradients myelin-sensitive T1 relaxometry, two complementary measures observed marked which varied as a content. In particular, microstructure changed result attention-mindfulness socio-cognitive regions functionally associated attention interoception, insular parietal cortices. Conversely, socio-affective resulted differential microstructural classically implicated interoceptive emotional processing, orbitofrontal areas, but did not reorganization. Notably, predicted change attention, compassion perspective-taking. work demonstrates plasticity after social-interoceptive illustrates bidirectional relationship between organisation skills.

Language: Английский

Citations

23
BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep DOI Creative Commons
Daniela Rojo, Louisa Dal Cengio, Anna Badner

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(22), P. 3604 - 3618.e11

Published: Aug. 31, 2023

Language: Английский

Citations

22
Prenatal influences on postnatal neuroplasticity: Integrating DOHaD and sensitive/critical period frameworks to understand biological embedding in early development DOI Creative Commons
Emma T. Margolis, Laurel J. Gabard‐Durnam

Infancy, Journal Year: 2024, Volume and Issue: unknown

Published: March 6, 2024

Abstract Early environments can have significant and lasting effects on brain, body, behavior across the lifecourse. Here, we address current research efforts to understand how experiences impact neurodevelopment with a new perspective integrating two well‐known conceptual frameworks – Developmental Origins of Health Disease (DOHaD) sensitive/critical period frameworks. Specifically, consider prenatal characterized in DOHaD model key neurobiological mechanisms periods for adapting learning from postnatal environment. We draw both animal human summarize state knowledge particular substance exposures (psychoactive substances heavy metals) nutritional profiles (protein‐energy malnutrition iron deficiency) each differentially brain circuits' excitation/GABAergic inhibition balance myelination. Finally, highlight directions that emerge this integrated framework, including testing alter timing identifying potential promotional/buffering periods. hope integrative framework considering influences neuroplasticity will stimulate early consequences our brains, behavior, health.

Language: Английский

Citations

8