Therapeutic mechanisms of psychedelics and entactogens

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(1), P. 104 - 118

Published: July 24, 2023

Language: Английский

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Overlapping representations of food and social stimuli in mouse VTA dopamine neurons

Neuron, Journal Year: 2023, Volume and Issue: 111(22), P. 3541 - 3553.e8

Published: Aug. 31, 2023

Language: Английский

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Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 3, 2024

Animals are inherently motivated to explore social novelty cues over familiar ones, resulting in a preference (NP), although the behavioral and circuit bases underlying NP unclear. Combining calcium neurotransmitter sensors with fiber photometry optogenetics mice, we find that mesolimbic dopamine (DA) neurotransmission is strongly predominantly activated by controlling bout length of interaction during NP, response significantly reduced familiarity. In contrast, interpeduncular nucleus (IPN) GABAergic neurons project lateral dorsal tegmentum (LDTg) were inhibited but terminations stimuli. Inhibition this pathway increased stimuli, while activation novel stimuli via decreasing DA neurotransmission. These data indicate interest towards encoded which dynamically regulated an IPN→LDTg control NP.

Language: Английский

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Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105675 - 105675

Published: April 11, 2024

Social behaviours are essential for animal survival, and the hypothalamic neuropeptide oxytocin (OXT) critically impacts bonding, parenting, decision-making. Dopamine (DA), is released by ventral tegmental area (VTA) dopaminergic neurons, regulating social cues in mesolimbic system. Despite extensive exploration of OXT DA roles behaviour independently, limited studies investigate their interplay. This narrative review integrates insights from human studies, particularly rodents, emphasising recent research on pharmacological manipulations or systems behaviour. Additionally, we correlating with blood/cerebral levels. Behavioural facets include sociability, cooperation, pair bonding parental care. In addition, provide into OXT-DA interplay models stress, autism schizophrenia. Emphasis placed complex relationship between collective influence across physiological pathological conditions. Understanding imbalance fundamental unravelling neurobiological underpinnings interaction reward processing deficits observed psychiatric

Language: Английский

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Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Social behaviors are crucial for human connection and belonging, often impacted by conditions like Autism Spectrum Disorder (ASD). The mesoaccumbens pathway (ventral tegmental area (VTA) to the nucleus accumbense (NAc)) plays a pivotal role in social behavior is implicated ASD. However, impact of ASD‐related mutations on reward processing remains insufficiently explored. This study focuses Shank3 mutation, associated with rare genetic condition linked ASD, examining its influence during behavior, using ‐deficient rat model. Our findings indicate that rats exhibit atypical interactions, altered neuronal activity VTA dopaminergic GABAergic neurons reduced dopamine release NAc. Moreover, they demonstrate manipulating can normalize this providing insights into effects identifying potential neural intervention.

Language: Английский

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Dopaminergic error signals retune to social feedback during courtship

Nature, Journal Year: 2023, Volume and Issue: 623(7986), P. 375 - 380

Published: Sept. 27, 2023

Language: Английский

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Characterizing the mechanisms of social connection

Neuron, Journal Year: 2023, Volume and Issue: 111(24), P. 3911 - 3925

Published: Oct. 6, 2023

Understanding how individuals form and maintain strong social networks has emerged as a significant public health priority result of the increased focus on epidemic loneliness myriad protective benefits conferred by connection. In this review, we highlight psychological neural mechanisms that enable us to connect with others, which in turn help buffer against consequences stress isolation. Central process is experience rewards derived from positive interactions, encourage sharing perspectives preferences unite individuals. Sharing affective states others helps align our understanding world another's, thereby continuing reinforce bonds strengthen relationships. These processes depend systems supporting reward cognitive function. Lastly, also consider limitations associated pursuing healthy connections outline potential avenues future research.

Language: Английский

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Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 151, P. 105243 - 105243

Published: May 22, 2023

Social behavior is naturally occurring in vertebrate species, which holds a strong evolutionary component and crucial for the normal development survival of individuals throughout life. Behavioral neuroscience has seen different influential methods social behavioral phenotyping. The ethological research approach extensively investigated natural habitats, while comparative psychology was developed utilizing standardized univariate tests. advanced precise tracking tools, together with post-tracking analysis packages, recently enabled novel phenotyping method, that includes strengths both approaches. implementation such will be beneficial fundamental but also enable an increased understanding influences many factors can influence behavior, as stress exposure. Furthermore, future increase number data modalities, sensory, physiological, neuronal activity data, thereby significantly enhance our biological basis guide intervention strategies abnormalities psychiatric disorders.

Language: Английский

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Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(4), P. 718 - 728

Published: Feb. 26, 2024

Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able study neuromodulator dynamics as interaction unfolds. Here, obtained subsecond estimates of dopamine from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had accept or reject monetary offers varying fairness computer players. They rejected more in than condition, an effect context associated higher overall levels but serotonin. Regardless context, relative changes tracked trial-by-trial offer value-akin reward prediction errors-whereas current value. These results show that fluctuations one basal ganglia's main output structures reflect distinct value signals.

Language: Английский

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Operant social self-administration in male CD1 mice

Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Abstract Rationale and Objective We recently introduced a model of operant social reward in which female CD1 mice lever press for access to affiliative interaction with cagemate peer mouse the same sex strain. Here we determined generality self-administration male who, under certain conditions, will attack subordinate mouse. Methods trained food strain different fixed-ratio (FR) schedule response requirements (FR1 FR6). then tested their motivation seek after 15 days isolation presence cues previously paired self-administration. also effect housing conditions on seeking. Finally, differences seeking, unconditioned antagonistic (aggressive) interactions both sexes. Results Male pressed FR days; these effects were independent conditions. There no group-housed did not display aggressive behavior toward Conclusions Adult socially housed can be used studies without potential confound responding engage interactions.

Language: Английский

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