Sleep—A brain-state serving systems memory consolidation

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1050 - 1075

Published: April 1, 2023

Language: Английский

---

Glymphatic influx and clearance are accelerated by neurovascular coupling

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(6), P. 1042 - 1053

Published: June 1, 2023

Language: Английский

---

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 20, 2023

Abstract Perivascular spaces are important highways for fluid and solute transport in the brain enabling efficient waste clearance during sleep. However, underlying mechanisms augmenting perivascular flow sleep unknown. Using two-photon imaging of naturally sleeping male mice we demonstrate cycle-dependent vascular dynamics pial arteries penetrating arterioles: slow, large-amplitude oscillations NREM sleep, a vasodilation REM vasoconstriction upon awakening at end cycle microarousals intermediate These mirrored by changes size slow fluctuations reduction an enlargement after By biomechanical modeling that these likely enhance to levels comparable cardiac pulsation-driven oscillations.

Language: Английский

---

Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(2), P. 249 - 258

Published: Jan. 18, 2024

Abstract Sleep interacts reciprocally with immune system activity, but its specific relationship microglia—the resident cells in the brain—remains poorly understood. Here, we show mice that microglia can regulate sleep through a mechanism involving G i -coupled GPCRs, intracellular Ca 2+ signaling and suppression of norepinephrine transmission. Chemogenetic activation strongly promoted sleep, whereas pharmacological blockade P2Y12 receptors decreased sleep. Two-photon imaging cortex showed P2Y12–G elevated , this elevation largely abolished -induced increase. Microglia level also increased at natural wake-to-sleep transitions, caused partly by reduced levels. Furthermore, biosensor significantly levels, increasing adenosine concentration. These findings indicate reciprocal interactions

Language: Английский

---

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Monitoring norepinephrine release in vivo using next-generation GRABNE sensors

Neuron, Journal Year: 2024, Volume and Issue: 112(12), P. 1930 - 1942.e6

Published: March 27, 2024

Language: Английский

---

Oxygen imaging of hypoxic pockets in the mouse cerebral cortex

Science, Journal Year: 2024, Volume and Issue: 383(6690), P. 1471 - 1478

Published: March 28, 2024

Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain cannot store oxygen, and interruption oxidative phosphorylation fatal minutes. Yet only rudimentary knowledge exists regarding cortical partial oxygen tension (

Language: Английский

---

The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117207 - 117207

Published: July 26, 2024

Language: Английский

---

Overnight neuronal plasticity and adaptation to emotional distress

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(4), P. 253 - 271

Published: March 5, 2024

Language: Английский

---

Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus

Neuron, Journal Year: 2024, Volume and Issue: 112(11), P. 1862 - 1875.e5

Published: March 26, 2024

Language: Английский

---