Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells

Glia, Journal Year: 2023, Volume and Issue: 71(6), P. 1383 - 1401

Published: Feb. 17, 2023

Abstract The mammalian brain is a complex organ comprising neurons, glia, and more than 1 × 10 14 synapses. Neurons are heterogeneous group of electrically active cells, which form the framework circuitry brain. However, glial primarily divided into astrocytes, microglia, oligodendrocytes (OLs), oligodendrocyte precursor cells (OPCs), constitute approximately half all neural in central nervous system (CNS) mainly provide nutrition tropic support to neurons In last two decades, concept “tripartite synapses” has drawn great attention, emphasizes that astrocytes an integral part synapse regulate neuronal activity feedback manner after receiving signals. Since then, synaptic modulation by been extensively studied substantially revised. this review, we summarize latest significant findings on how particular, microglia OL lineage impact remodel structure function synapses Our review highlights cellular molecular aspects neuron‐glia crosstalk provides additional information aberrant communication between glia may contribute pathologies.

Language: Английский

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Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 10, 2024

Abstract Anxiety-associated symptoms following acute stress usually become extinct gradually within a period of time. However, the mechanisms underlying how individuals cope with to achieve extinction anxiety are not clear. Here we show that restraint causes an increase in activity GABAergic neurons CeA (GABA ) male mice, resulting anxiety-like behaviors 12 hours; meanwhile, elevated GABA neuronal CX3CL1 secretion via MST4 (mammalian sterile-20-like kinase 4)-NF-κB-CX3CL1 signaling consequently activates microglia CeA. Activated turn inhibit engulfment their dendritic spines, ultimately leading induced by stress. These findings reveal dynamic molecular and cellular mechanism which drive negative feedback activity, thus facilitating maintenance brain homeostasis response

Language: Английский

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Multiphoton fluorescence microscopy for in vivo imaging

Cell, Journal Year: 2024, Volume and Issue: 187(17), P. 4458 - 4487

Published: Aug. 1, 2024

Language: Английский

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Adaptive and maladaptive myelination in health and disease

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(12), P. 735 - 746

Published: Nov. 14, 2022

Language: Английский

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Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis

Immunity, Journal Year: 2023, Volume and Issue: 56(9), P. 2105 - 2120.e13

Published: July 31, 2023

Childhood neglect and/or abuse can induce mental health conditions with unknown mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated synapse phagocytosis. Using in vitro, vivo, and human brain organoid experiments, showed that increased the expression Mertk phagocytic receptor astrocytes through glucocorticoid (GR). In post-natal mice, exposure to early social deprivation (ESD) specifically activated GR-MERTK pathway astrocytes, but not microglia. The excitatory post-synaptic density cortical regions was reduced ESD there an increase astrocytic engulfment these synapses. loss synapses, abnormal neuronal network activities, behavioral abnormalities mice were largely prevented by ablating GR or MERTK astrocytes. Our work reveals critical roles activation evoking stress-induced behaviors suggesting signaling a therapeutic target for conditions.

Language: Английский

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Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(8), P. 628 - 639

Published: June 5, 2023

Oligodendrocyte precursor cells (OPCs) are non-neuronal brain that give rise to oligodendrocytes, glia myelinate the axons of neurons in brain. Classically known for their contributions myelination via oligodendrogenesis, OPCs increasingly appreciated play diverse roles nervous system, ranging from blood vessel formation antigen presentation. Here, we review emerging literature suggesting may be essential establishment and remodeling neural circuits developing adult mechanisms distinct production oligodendrocytes. We discuss specialized features position these integrate activity-dependent molecular cues shape wiring. Finally, place within context a growing field focused on understanding importance communication between contexts both health disease.

Language: Английский

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Pathological potential of oligodendrocyte precursor cells: terra incognita

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(7), P. 581 - 596

Published: May 12, 2023

Language: Английский

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Myelination-independent functions of oligodendrocyte precursor cells in health and disease

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1663 - 1669

Published: Aug. 31, 2023

Language: Английский

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Neuron–oligodendroglial interactions in health and malignant disease

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 733 - 746

Published: Oct. 19, 2023

Language: Английский

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Astrocyte-dependent circuit remodeling by synapse phagocytosis

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 81, P. 102732 - 102732

Published: May 27, 2023

Language: Английский

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